DRSC/TRiP Functional Genomics Resources

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Protein Alignment anne and ATP13A1

DIOPT Version :9

Sequence 1:NP_001096849.1 Gene:anne / 317815 FlyBaseID:FBgn0052000 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_065143.2 Gene:ATP13A1 / 57130 HGNCID:24215 Length:1204 Species:Homo sapiens


Alignment Length:1351 Identity:333/1351 - (24%)
Similarity:525/1351 - (38%) Gaps:378/1351 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 CW-----------------ACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLVTEDYQGK 224
            ||                 |.|.|...|..|..||..|.:...||             |.:|...
Human    86 CWGWGSSWVQIPEAALLVLATICLAHALTVLSGHWSVHAHCALTC-------------TPEYDPS 137

  Fly   225 HKMYHVKQIQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRCK 289
            ...:    ::|:.:.|        ..|.|...:..:..|:.|::    .|.:|:|          
Human   138 KATF----VKVVPTPN--------NGSTELVALHRNEGEDGLEV----LSFEFQK---------- 176

  Fly   290 QLVYAWNNNTNRFQRINGLDLNIPC----SYYHQQRGLPVHEQI-SRRIVFGDNEITVPLRDFKT 349
             :.|::    :..::...|.:..|.    |||...||.....:| :....||.|:..:.:.||..
Human   177 -IKYSY----DALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFSE 236

  Fly   350 LLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQK-------- 406
            |.......||:|||:|.|.||...:|:||:...|.|.|......|.|..:|...::|        
Human   237 LFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHMI 301

  Fly   407 TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEI---PSSGCTLHCDAILISGNCILDESMLTGES 468
            .||.: ..|        :.:.:..||||||:.|   |... .:.||.:|:.|.||:||:||||||
Human   302 QVYRS-RKW--------RPIASDEIVPGDIVSIGRSPQEN-LVPCDVLLLRGRCIVDEAMLTGES 356

  Fly   469 VPVTKTPLPS-KRDMIFDKTEHAR-HTLFCGTKVI-----QTRYIGSKKV----LAFVINTGNIT 522
            ||..|.|:.. ..|.:.|....:| |.:|.||||:     |....|.|.|    :|:|:.||..|
Human   357 VPQMKEPIEDLSPDRVLDLQADSRLHVIFGGTKVVQHIPPQKATTGLKPVDSGCVAYVLRTGFNT 421

  Fly   523 AKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGT-DP----VKIAVESL 582
            ::|:|:|:||:..........:::.||.||.:.|.....|..:    .|| ||    .|:.:|..
Human   422 SQGKLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWI----EGTKDPSRNRYKLFLECT 482

  Fly   583 DLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWG 647
            .::|.||||.||..:::....:...|....::|..|..|..||.:..||||||||||.|.|.:.|
Human   483 LILTSVVPPELPIELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRG 547

  Fly   648 VV----PKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITIL-NGRMMGDPLDLKMFESTGWELE 707
            |.    .|..|....||:::...|         .:|||:..| :|.::||||:..|..:..|.|.
Human   548 VAGLRDGKEVTPVSSIPVETHRAL---------ASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLT 603

  Fly   708 DSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHG 772
            ....:         :|..::                               |.|:...|:     
Human   604 KDEKV---------FPRSIK-------------------------------TQGLKIHQR----- 623

  Fly   773 IVREFPFTSALQRMSVVTRC----LSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKG 833
                |.|.|||:||||:...    .:|..:....||:||.|..:.  ...|.:|....:|.:::|
Human   624 ----FHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMF--SQCPPDYHHIHTEISREG 682

  Fly   834 YRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMI 898
            .|::|:.:|.|.| :.:.:.:.:.||.:|.:::|:||:::...||.|:..||..:..|..|.:||
Human   683 ARVLALGYKELGH-LTHQQAREVKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMI 746

  Fly   899 TGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLG 963
            ||||.|||..||::...:..:.::|   ..|       .:..|.:|.: .|.|....|  .|..|
Human   747 TGDNPLTACHVAQELHFIEKAHTLI---LQP-------PSEKGRQCEW-RSIDGSIVL--PLARG 798

  Fly   964 SKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVK 1028
            |..:.|..:..|.                                           |.|.||.::
Human   799 SPKALALEYALCL-------------------------------------------TGDGLAHLQ 820

  Fly  1029 TIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQK 1093
            ..|                                        |:::..|:....::||::|.||
Human   821 ATD----------------------------------------PQQLLRLIPHVQVFARVAPKQK 845

  Fly  1094 QALVIELQNLDYCVAMCGDGANDCGALKVAHAGISL----------------------------- 1129
            :.::..|:.|.|...|||||.||.||||.|..|::|                             
Human   846 EFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPTLSNSGIRAT 910

  Fly  1130 SET---------------------------------------EASIASPFTSRNPTISAVLKVIK 1155
            |.|                                       :||||:||||:..:|..:..|||
Human   911 SRTAKQRSGLPPSEEQPTSQRDRLSQVLRDLEDESTPIVKLGDASIAAPFTSKLSSIQCICHVIK 975

  Fly  1156 EGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDG 1220
            :||..|||:..:||.:|..:|:...|..:||......:|.|.....|.|...|.|          
Human   976 QGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLF---------- 1030

  Fly  1221 MLVEQVPLSSLISSTPLA---SLLLHLTVVTAFQV--TCWVHLHQQ-------------PWFKAF 1267
             :....||.:|....||.   :|...|||:..|.|  ...|:|:::             ..:|.|
Human  1031 -ISRSKPLKTLSRERPLPNIFNLYTILTVMLQFFVHFLSLVYLYREAQARSPEKQEQFVDLYKEF 1094

  Fly  1268 EPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYP 1332
            ||:       ..|.|::.::....:....:..||.|:.:.|..|.||..:..|:|..|:.|:|..
Human  1095 EPS-------LVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLAVSLLAIIGLLLGS 1152

  Fly  1333 SDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQV 1383
            |....|.|.|:..| :.|:.|:.......|...:..:..|..:|...|.:|
Human  1153 SPDFNSQFGLVDIP-VEFKLVIAQVLLLDFCLALLADRVLQFFLGTPKLKV 1202

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
anneNP_001096849.1 P5-ATPase 158..291 CDD:289194 23/130 (18%)
P-ATPase-V 173..1355 CDD:273738 328/1321 (25%)
E1-E2_ATPase 381..621 CDD:278548 81/266 (30%)
Cation_ATPase <758..813 CDD:289987 18/58 (31%)
HAD_like <1087..1137 CDD:304363 25/117 (21%)
ATP13A1NP_065143.2 P-ATPase-V 85..1173 CDD:273738 327/1320 (25%)
A-domain, part 1. /evidence=ECO:0000250|UniProtKB:P39986 199..230 9/30 (30%)
A-domain, part 2. /evidence=ECO:0000250|UniProtKB:P39986 295..435 52/149 (35%)
E1-E2_ATPase 298..510 CDD:278548 72/225 (32%)
P-domain, part 1. /evidence=ECO:0000250|UniProtKB:P39986 512..541 15/28 (54%)
N-domain. /evidence=ECO:0000250|UniProtKB:P39986 543..724 54/241 (22%)
Cation_ATPase 584..667 CDD:289987 26/133 (20%)
HAD 643..873 CDD:289480 75/328 (23%)
P-domain, part 2. /evidence=ECO:0000250|UniProtKB:P39986 727..885 57/253 (23%)
COG4087 <831..>884 CDD:226572 22/52 (42%)
Arm-like. /evidence=ECO:0000250|UniProtKB:P39986 886..949 2/62 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 889..933 2/43 (5%)
P-domain, part 3. /evidence=ECO:0000250|UniProtKB:P39986 950..965 8/14 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54176
OrthoDB 1 1.010 - - D172453at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.930

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