Protein Alignment anne and atp7a

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001036185.1
• Gene: atp7a / 564924
• ZFINID: ZDB-GENE-060825-45
• Length: 1482
• Species: Danio rerio
• Alignment Length: 1246
• Identity: 233/1246 - (18%)
• Similarity: 418/1246 - (33%)
• Gaps: 389/1246 - (31%)

  Fly    63 DMHYVATESVQPKKSDKVPSNKIKKVENNNTLVNGCSKTSARSVPLLKYNRPDQDGDSEENITSV 127
            ||.:   ::..|:.:..|||    .|::.:..|...|.:..||.  :|.|..:.|.:...|..|.
Zfish   419 DMGF---DAFLPETNSLVPS----VVKSPSPSVRSSSLSPVRSA--VKENEAESDAEPSTNTISK 474

  Fly   128 ----------------LEPNVDEIYSKDSERLVDDSKPCIGLLNPDQEDQMKVCGYRRSLMRTGF 176
                            :|.|:...|...|..:...:.......:|...|.:::....|.|..|..
Zfish   475 CFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTAT 539

  Fly   177 CWACIFLTGGLLRLVLHWWRHLYLYATCSQC------SLEEAEQVLVTEDYQGKHKMYHVKQ--- 232
            .......:.|.|.||:..       .||:.|      :|.:.:.:|........:|. |:|.
Zfish   540 VMDNYDGSDGSLELVVRG-------MTCASCVHKIESNLMKQKGILYASVALSTNKA-HIKYDPE 596

  Fly   233 -------IQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRC-- 288
                   |:::.:......|.|:    :|.....||...:         .|:|:...|.:|.|
Zfish   597 VTGPRDIIRLIENMGFTASLVKK----DRPGSHLDHSREI---------RQWKRSFQISLFFCVP 648

  Fly   289 --KQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDFKTLL 351
              ..::|.             :.::.....|||.......::..                :.:.:
Zfish   649 VMGMMIYM-------------IVVDHMIDKYHQHHNATAEDRAK----------------YHSTM 684

  Fly   352 FLE--------VLNPFYVFQLFSVILWFTYDYYYYA--------------CVILLMSVFGITVSV 394
            |||        ::|  .:..||.|.:.|....|:|.              .:|:|.:....|.||
Zfish   685 FLEKQLLPGLSIMN--LISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSV 747

  Fly   395 -------------------------------------LQTKKNQDVLQKTV-YNTGNAWVV---- 417
                                                 :...|..:.|.|.: .....|.||
Zfish   748 VVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNE 812

  Fly   418 DHKGLSKE-LPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLTGESVPVTKTPLPSKRD 481
            |...||:| :....:..||::::...| ....|..:|.|:.:.|||::|||::||||.|
Zfish   813 DMSVLSEEQVDVELVQRGDVVKVVPGG-KFPVDGRVIEGHSMADESLITGEAMPVTKKP------ 870

  Fly   482 MIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSY 546
               ..|..|......|:.:|:..::|:...|:.::   .:..:.:..::     |:....::.|.
Zfish   871 ---GSTVIAGSINQNGSLLIKATHVGTDTTLSQIV---KLVEEAQTSKA-----PIQQFADKISS 924

  Fly   547 KFIQFLAIIA--------CVGFI-YTLVTKILRGTDP--------VKIAVE-SLDLITIVVPPAL 593
            .|:.|:.:|:        .:||: ::||.....|.|.        ::.|.: |:.::.|..|.:|
Zfish   925 YFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAVIRFAFQASITVLCIACPCSL 989

  Fly   594 ----PAAMTVGRFYAQKR---LKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPK 651
                |.|:.||.....:.   :|..|       .:.:|..|....||||||:|      :| .||
Zfish   990 GLATPTAVMVGTGVGAQNGILIKGGE-------PLEMAHKIQSVVFDKTGTIT------YG-APK 1040

  Fly   652 SSTNQFQIP-LKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDT 715
                ..|:. |...:|||....|..:.|..:.:       ..||...:.:....||       .|
Zfish  1041 ----VVQVKMLAEGNRLPRSKLLAIVGTAENSS-------EHPLGAAITKYCKQEL-------GT 1087

  Fly   716 EKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIV------ 774
            |..|..  |..:...|  .|:....|.::|.:||:.           |.|::|..:.::
Zfish  1088 ESLGTC--TDFQAVPG--CGIRCLVSNTENLLKRED-----------SDSEENQHNAVLIQISDA 1137

  Fly   775 ----REFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYR 835
                .|.|.....|.::||.......:.     |:.|.:::  ....:..:..:.::|..::|..
Zfish  1138 RAHSTEHPLIMDPQPLTVVQTASYTVLI-----GNREWMRR--NALQVRADVDEAMTEHERRGCT 1195

  Fly   836 IIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITG 900
            .:.:|                    |:|  |....|.:.:.:||:....::.|:|..:..:::||
Zfish  1196 AVLVA--------------------VDN--ELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTG 1238

  Fly   901 DNILTAISVARDCGI------VSPSQSVITVH------------ADPIGDS-------ANIQTNT 940
            ||..||.::|...||      |.||..|..|.            .|.:.||       ..|...|
Zfish  1239 DNSKTARAIAAQVGIRKVFAEVLPSHKVAKVEQLQQAGKRVAMVGDGVNDSPALAMADVGIAIGT 1303

  Fly   941 GTECNFDNSS-----DKHYKLHYTLDLGSKTSRA----YLFKSCFN-------SNLFDPETPEFT 989
            ||:...:.:.     :....:..::||..||.:.    ::|...:|       :.:|.|
Zfish  1304 GTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMP------ 1362

  Fly   990 AQVGKTIFHMESTNSLVNESTSSYAESGL------PTSDSLASVKTIDTWTHNDAELGIKHTPDE 1048
              ||..:.....:.::...|.|....|.|      ||.:.|.. :..|..||........|....
Zfish  1363 --VGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEKLKR-RLGDVRTHGSLSDVSVHIGMG 1424

  Fly  1049 SWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMS------------------PDQKQA 1095
            ..||                   |.....||.|...|:|.|                  ||:...
Zfish  1425 ELRR-------------------PSPKLSLLDRFVNYSRASINSLRSDKHSMNSMALSEPDKHSL 1470

  Fly  1096 LVIELQNLDYC 1106
            ||.:    |:|
Zfish  1471 LVGD----DHC 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	28/157 (18%)
		P-type_ATPase_cation	326..1281	CDD:319842	181/947 (19%)
atp7a	NP_001036185.1	CopZ	9..72	CDD:442020
		CopZ	173..240	CDD:442020
		HMA	279..336	CDD:238219
		CopZ	361..424	CDD:442020	2/7 (29%)
		HMA	477..539	CDD:238219	9/61 (15%)
		HMA	552..615	CDD:238219	11/70 (16%)
		P-type_ATPase_Cu-like	637..1377	CDD:319783	162/872 (19%)