DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp2b2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001116710.1	Gene:	atp2b2 / 557430	ZFINID:	ZDB-GENE-061016-1	Length:	1253	Species:	Danio rerio

Alignment Length:	1320	Identity:	252/1320 - (19%)
Similarity:	421/1320 - (31%)	Gaps:	474/1320 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY-------YAC----- 380
            |:.|||.|  .:|.:..||.|.|  |.|....:..| .:.::.....:|.       .||
Zfish    75 RKEVFGRN--LIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQPPGEGNTDACGDAKA 137

  Fly   381 ----------------VILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVV 417
                            .|||..|..:.|:.            ||::..|:  ||        :.|
Zfish   138 GAEDEGESEAGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQE--QK--------FQV 192

  Fly   418 DHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGES------------- 468
            ...|...:||...|:.|||.:| ..|..|..|.:||.||.: :|||.|||||
Zfish   193 VRGGQVIQLPVADILVGDIAQI-KYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAADKDPML 256

  Fly   469 ------------VPVTKTPLPSKRDMIF----------DKTEHARHTLFCGTKVIQTRYIGSKKV 511
                        :.||...:.|:..:||          :|.|.....|..|..:....:..|..:
Zfish   257 LSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLGAGGEEEEKKEKKGQALEDGHPLPDCSHPSSHPI 321

  Fly   512 LAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKF---------------------------- 548
             |.:...|..:|......|::.....|...|.:..|.
Zfish   322 -ATIATDGAASANTPANTSLVNGKMQDGNMENNQTKVKKQDGAAAMEMQPLKSAEGGETEEKEKK 385

  Fly   549 ---------------IQFLAI-IACVGFIYTLVTKIL-----------RGTDP------------ 574
                           :..||: |...|.:.:.:|.|:           |...|
Zfish   386 KTSVSKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPWLTECTPIYIQY 450

  Fly   575 -VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTL 638
             ||..:..:.::.:.||..||.|:|:...|:.|::...........:....|:....|.||||||
Zfish   451 FVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 515

  Fly   639 TEDGLDM---------WGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPL 694
            |.:.:..         :..:|:.::    :|.|::|      .|...::.:|..
Zfish   516 TTNRMTAVQVYVADVHYKTIPEPTS----LPSKTLD------ILVNAISLNSAY----------- 559

  Fly   695 DLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLAT 759
                          :..|...:|.|.|...:..:...|..|:..........|:.|
Zfish   560 --------------TTKILPADKEGGLPKQVGNKTECGFLGLVLDVKRDYQTIRNQ--------- 601

  Fly   760 VGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLC----------- 813
               .|.:|     :.:.:.|.|..:.||.|.: |.|..|.:|.||:.|::.|.|
Zfish   602 ---IPEEK-----LYKVYTFNSVRKSMSTVIK-LPDGSFRMYSKGASEIILKKCSRILSEVGEPR 657

  Fly   814 --KPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENN----MEFLGFVI 872
              :|:...:...:.:...|..|.|.|.:.::      ::.|....:.|: |||    :..:..|.
Zfish   658 VFRPRDRDEMVKKVIEPMACDGLRTICVGYR------DFPKDPEPNWED-ENNILTDLTAICVVG 715

  Fly   873 LENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQ 937
            :|:.::|:....|.....|.|...|:|||||.||.::|..|||:.|.:..:.:.
Zfish   716 IEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCID----------- 769

  Fly   938 TNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMEST 1002
                                                                   ||     |..
Zfish   770 -------------------------------------------------------GK-----EFN 774

  Fly  1003 NSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIV 1067
            ..:.||.                          .:.|             ||.|    .|.|..:
Zfish   775 RRIRNEK--------------------------GEVE-------------QERI----DKVWPKL 796

  Fly  1068 KDYFPEEMEILLTRGSIYARMSPDQKQALV---IELQNLD--YCVAMCGDGANDCGALKVAHAGI 1127
            :               :.||.||..|..||   |:...:|  ..||:.|||.||..|||.|..|.
Zfish   797 R---------------VLARSSPTDKHTLVKGIIDSTLVDQRQVVAVTGDGTNDGPALKKADVGF 846

  Fly  1128 SLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILY--- 1186
            ::......:   ||.....:...|:::|.:..||....:   |.|::.....|..::|::.:
Zfish   847 AMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTVNVVAVIVAFTGA 908

  Fly  1187 --SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISSTPLASLLLH--L 1244
              :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   ..|||||...::|.|  .
Zfish   909 CITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVY 972

  Fly  1245 TVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLW 1309
            .:|..|.:                        .|....:|.|.|          .:.||...|..
Zfish   973 QLVIIFSL------------------------LFVGEQIFDIDS----------GRNAPLHSPPS 1003

  Fly  1310 SNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFRYVMLAYGAAS 1361
            .::.:    |.|..:::.|.             ::...:....|..||..|...:.|::.:|...
Zfish  1004 EHYTI----IFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCSIVVGTFAIQIVIVQFGGKP 1064

  Fly  1362 FICH-IFVESFLVEYLVFKKYQVKREKNW-------VTSKQKYMRLEHDISNIKNWPPITEVYEP 1418
            |.|. :.:|.::  :.||..   ..|..|       ..||.:::|....::. |:..|..|:.|.
Zfish  1065 FSCSPLDLEKWM--WCVFLG---MGELVWGQVISTIPNSKLRFLRGAGQLTQ-KDEMPEEEMNED 1123

  Fly  1419 NNLIDCETEQPTYVSLHAEQ 1438
            ...||           |||:
Zfish  1124 QEEID-----------HAER 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	232/1227 (19%)
		E1-E2_ATPase	381..621	CDD:278548	69/355 (19%)
		Cation_ATPase	<758..813	CDD:289987	15/54 (28%)
		HAD_like	<1087..1137	CDD:304363	20/57 (35%)
atp2b2	NP_001116710.1	ATPase-IIB_Ca	9..1096	CDD:273668	240/1270 (19%)
		Cation_ATPase_N	48..115	CDD:279080	13/41 (32%)
		E1-E2_ATPase	191..499	CDD:278548	59/309 (19%)
		Cation_ATPase	560..649	CDD:289987	24/106 (23%)
		HAD	657..840	CDD:289480	57/318 (18%)
		Cation_ATPase_C	914..1092	CDD:279079	44/221 (20%)
		ATP_Ca_trans_C	1137..1184	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930