Protein Alignment anne and atp2b2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_073772018.1
• Gene: atp2b2 / 557430
• ZFINID: ZDB-GENE-061016-1
• Length: 1256
• Species: Danio rerio
• Alignment Length: 1320
• Identity: 253/1320 - (19%)
• Similarity: 422/1320 - (31%)
• Gaps: 474/1320 - (35%)

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY-------YAC----- 380
            |:.|||.|  .:|.:..||.|.|  |.|....:..| .:.::.....:|.       .||
Zfish    78 RKEVFGRN--LIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQPPGEGNTDACGDAKA 140

  Fly   381 ----------------VILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVV 417
                            .|||..|..:.|:.            ||::..|:  ||        :.|
Zfish   141 GAEDEGESEAGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQE--QK--------FQV 195

  Fly   418 DHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGES------------- 468
            ...|...:||...|:.|||.:| ..|..|..|.:||.||.: :|||.|||||
Zfish   196 VRGGQVIQLPVADILVGDIAQI-KYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAADKDPML 259

  Fly   469 ------------VPVTKTPLPSKRDMIF----------DKTEHARHTLFCGTKVIQTRYIGSKKV 511
                        :.||...:.|:..:||          :|.|.....|..|..:....:..|..:
Zfish   260 LSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLGAGGEEEEKKEKKGQALEDGHPLPDCSHPSSHPI 324

  Fly   512 LAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKF---------------------------- 548
             |.:...|..:|......|::.....|...|.:..|.
Zfish   325 -ATIATDGAASANTPANTSLVNGKMQDGNMENNQTKVKKQDGAAAMEMQPLKSAEGGETEEKEKK 388

  Fly   549 ---------------IQFLAI-IACVGFIYTLVTKIL-----------RGTDP------------ 574
                           :..||: |...|.:.:.:|.|:           |...|
Zfish   389 KTSVSKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPWLTECTPIYIQY 453

  Fly   575 -VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTL 638
             ||..:..:.::.:.||..||.|:|:...|:.|::...........:....|:....|.||||||
Zfish   454 FVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 518

  Fly   639 TEDGLDM---------WGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPL 694
            |.:.:..         :..:|:.::    :|.|::|      .|...::.:|..
Zfish   519 TTNRMTAVQVYVADVHYKTIPEPTS----LPSKTLD------ILVNAISLNSAY----------- 562

  Fly   695 DLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLAT 759
                          :..|...:|.|.|...:..:...||.|:..........|:.|
Zfish   563 --------------TTKILPADKEGGLPKQVGNKTECGLLGLVLDLKRDYQTIRNQ--------- 604

  Fly   760 VGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLC----------- 813
               .|.:|     :.:.:.|.|..:.||.|.: |.|..|.:|.||:.|::.|.|
Zfish   605 ---IPEEK-----LYKVYTFNSVRKSMSTVIK-LPDGSFRMYSKGASEIILKKCSRILSEVGEPR 660

  Fly   814 --KPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENN----MEFLGFVI 872
              :|:...:...:.:...|..|.|.|.:.::      ::.|....:.|: |||    :..:..|.
Zfish   661 VFRPRDRDEMVKKVIEPMACDGLRTICVGYR------DFPKDPEPNWED-ENNILTDLTAICVVG 718

  Fly   873 LENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQ 937
            :|:.::|:....|.....|.|...|:|||||.||.::|..|||:.|.:..:.:.
Zfish   719 IEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCID----------- 772

  Fly   938 TNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMEST 1002
                                                                   ||     |..
Zfish   773 -------------------------------------------------------GK-----EFN 777

  Fly  1003 NSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIV 1067
            ..:.||.                          .:.|             ||.|    .|.|..:
Zfish   778 RRIRNEK--------------------------GEVE-------------QERI----DKVWPKL 799

  Fly  1068 KDYFPEEMEILLTRGSIYARMSPDQKQALV---IELQNLD--YCVAMCGDGANDCGALKVAHAGI 1127
            :               :.||.||..|..||   |:...:|  ..||:.|||.||..|||.|..|.
Zfish   800 R---------------VLARSSPTDKHTLVKGIIDSTLVDQRQVVAVTGDGTNDGPALKKADVGF 849

  Fly  1128 SLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILY--- 1186
            ::......:   ||.....:...|:::|.:..||....:   |.|::.....|..::|::.:
Zfish   850 AMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTVNVVAVIVAFTGA 911

  Fly  1187 --SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISSTPLASLLLH--L 1244
              :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   ..|||||...::|.|  .
Zfish   912 CITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVY 975

  Fly  1245 TVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLW 1309
            .:|..|.:                        .|....:|.|.|          .:.||...|..
Zfish   976 QLVIIFSL------------------------LFVGEQIFDIDS----------GRNAPLHSPPS 1006

  Fly  1310 SNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFRYVMLAYGAAS 1361
            .::.:    |.|..:::.|.             ::...:....|..||..|...:.|::.:|...
Zfish  1007 EHYTI----IFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCSIVVGTFAIQIVIVQFGGKP 1067

  Fly  1362 FICH-IFVESFLVEYLVFKKYQVKREKNW-------VTSKQKYMRLEHDISNIKNWPPITEVYEP 1418
            |.|. :.:|.::  :.||..   ..|..|       ..||.:::|....::. |:..|..|:.|.
Zfish  1068 FSCSPLDLEKWM--WCVFLG---MGELVWGQVISTIPNSKLRFLRGAGQLTQ-KDEMPEEEMNED 1126

  Fly  1419 NNLIDCETEQPTYVSLHAEQ 1438
            ...||           |||:
Zfish  1127 QEEID-----------HAER 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	219/1140 (19%)
atp2b2	XP_073772018.1	None