Protein Alignment anne and ATP4A

DIOPT Version :9

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_000695.2
• Gene: ATP4A / 495
• HGNCID: 819
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 1103
• Identity: 228/1103 - (20%)
• Similarity: 389/1103 - (35%)
• Gaps: 338/1103 - (30%)

  Fly   372 TYDYYYYA----CVILLMSVFGI-----TVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELP 427
            |.|..|.|    .|:::...||.     :.:::.:.||....|.||...|:.:         ::.
Human   137 TDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKF---------QIN 192

  Fly   428 TRAIVPGDIIEIPSSGCTLHCD-AILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHAR 491
            ...:|.||::|: ..|..:..| .||.:..|.:|.|.|||||.|.|::|     :...:.....|
Human   193 ADQLVVGDLVEM-KGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSP-----ECTHESPLETR 251

  Fly   492 HTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSIL-----YPPPVDYKFEQDSYKFIQF 551
            :..|..|..::    |:  |...|:|||:.|..|. |.|:.     ...|:..:.|.    |:..
Human   252 NIAFFSTMCLE----GT--VQGLVVNTGDRTIIGR-IASLASGVENEKTPIAIEIEH----FVDI 305

  Fly   552 LAIIA------------CVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYA 604
            :|.:|            |:|:.:            ::..|..:.::...||..|.|.:||.....
Human   306 IAGLAILFGATFFIVAMCIGYTF------------LRAMVFFMAIVVAYVPEGLLATVTVCLSLT 358

  Fly   605 QKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPF 669
            .|||.:......:..::...||.:..|.|||||||::.:                   :|..|.|
Human   359 AKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRM-------------------TVSHLWF 404

  Fly   670 DHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLS 734
            |:.:....|..                   :.:|...:.|     :|.:..|...:.      |.
Human   405 DNHIHTADTTE-------------------DQSGQTFDQS-----SETWRALCRVLT------LC 439

  Fly   735 GMAETESGSKN-EIKRQSSVDDLLATVGISPSQKNFDHGI--------VREFPFTSALQ-RMSVV 789
            ..|..:||... .:.::..:.|...|..:..|:....:.:        |.|.||.|..: ::|:.
Human   440 NRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIH 504

  Fly   790 T-RCLSDQVFNVYCKGSPEMLKKLC-----KPQSLPDNYSQQLSEFAKKGY--------RIIAIA 840
            | ....|....:..||:||.:.:.|     |.|.||  ..:|..|..:..|        |::...
Human   505 TLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELP--LDEQWREAFQTAYLSLGGLGERVLGFC 567

  Fly   841 FKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDN 902
            ...|:.| :|........|.:......|.|..|.:.:.|....|.:|:   ..|.||.||:|||:
Human   568 QLYLNEK-DYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDH 631

  Fly   903 ILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTS 967
            .:||.::|...||:|.                                            ||:|
Human   632 PITAKAIAASVGIISE--------------------------------------------GSET- 651

  Fly   968 RAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKT-ID 1031
                                                                ..|..|.::. :|
Human   652 ----------------------------------------------------VEDIAARLRVPVD 664

  Fly  1032 TWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEM-EILLTRGS-IYARMSPDQKQ 1094
            .....||              :.|:  ::|..   :||..|.|: |.|.|... ::||.||.||.
Human   665 QVNRKDA--------------RACV--INGMQ---LKDMDPSELVEALRTHPEMVFARTSPQQKL 710

  Fly  1095 ALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRA 1159
            .:|...|.|...||:.|||.||..|||.|..|:::     .||....::|   :|.:.::.:..|
Human   711 VIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAM-----GIAGSDAAKN---AADMILLDDNFA 767

  Fly  1160 ALVTS-------FGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVD----LGLISIF----- 1208
            ::||.       |...|...||:|.:.|..:..|.|        |:.|.    ||.|:|.
Human   768 SIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLI--------YITVSVPLPLGCITILFIELC 824

  Fly  1209 -------AFFFGKTESFDGMLVEQVPLSSLISSTPLASL-LLHLTVVTAFQ--VTCWVHLHQQPW 1263
                   :..:.|.||....|..:.|....:.:.|||:. ...:..:.:|.  ...:..:.|:.|
Human   825 TDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGW 889

  Fly  1264 FK----AFEPADEDH--------------LG--CFENYTMFCI--SSFQYIILAFVFSKG----A 1302
            |.    ......|||              .|  .::.||.:.:  .|.:...:|.|..:.    :
Human   890 FPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLS 954

  Fly  1303 PYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWVASFFQLIVPPTMRFRY--VMLAYGAASFI 1363
            .:::..:.|..|.:|.:..:||..:|...|.  :.:.|..:   .:||::  |.|.||...|:
Human   955 AFQQGFFRNKILVIAIVFQVCIGCFLCYCPG--MPNIFNFM---PIRFQWWLVPLPYGILIFV 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	224/1093 (20%)
		E1-E2_ATPase	381..621	CDD:278548	58/262 (22%)
		Cation_ATPase	<758..813	CDD:289987	14/64 (22%)
		HAD_like	<1087..1137	CDD:304363	20/49 (41%)
ATP4A	NP_000695.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		H-K_ATPase_N	2..>22	CDD:312544
		ATPase-IIC_X-K	43..1035	CDD:273445	228/1103 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840