DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and ATP2B2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_016861981.1	Gene:	ATP2B2 / 491	HGNCID:	815	Length:	1272	Species:	Homo sapiens

Alignment Length:	1248	Identity:	246/1248 - (19%)
Similarity:	397/1248 - (31%)	Gaps:	463/1248 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 GLP--VHEQISRRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY---- 377
            |||  ..:...|:.:||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|:
Human    67 GLPGTAPDLEKRKQIFGQN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGE 129

  Fly   378 -----------------------YACVILLMSVFGITVSV------------LQTKKNQDVLQK- 406
                                   ....|||..:..:.|:.            ||::..|:  ||
Human   130 GNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQE--QKF 192

  Fly   407 TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVP 470
            ||...|.  ||       ::|...||.|||.:: ..|..|..|.:.|.||.: :|||.|||||..
Human   193 TVVRAGQ--VV-------QIPVAEIVVGDIAQV-KYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247

  Fly   471 VTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVI----NTGNI---------- 521
            |.|:         .||..    .|..||.|::    ||.::|...:    .||.|
Human   248 VRKS---------VDKDP----MLLSGTHVME----GSGRMLVTAVGVNSQTGIIFTLLGAGGEE 295

  Fly   522 ------------------------------TAKGELIRSILYPPPVD------------------ 538
                                          :|...|:...:....||
Human   296 EEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQ 360

  Fly   539 ------------------YKFEQD--SYKFIQFLAIIACVGFIYTLVTKI--------------- 568
                              :|.|:.  ..|..:....|...|.:.:.:|.|
Human   361 PLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNK 425

  Fly   569 ---LRGTDP------VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVA 624
               |....|      ||..:..:.::.:.||..||.|:|:...|:.|::...........:....
Human   426 KPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM 490

  Fly   625 GSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRM 689
            |:....|.|||||||              ||:                         :|::.. .
Human   491 GNATAICSDKTGTLT--------------TNR-------------------------MTVVQA-Y 515

  Fly   690 MGDPLDLKMFESTGWELEDSNNIPDTEKYGIL---------YPTILRQPRGGLSGMAETESGSKN 745
            :|| :..|       |:.|.::| :|:...:|         |.|.:..|.  ..|....:.|:|.
Human   516 VGD-VHYK-------EIPDPSSI-NTKTMELLINAIAINSAYTTKILPPE--KEGALPRQVGNKT 569

  Fly   746 EIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPE-ML 809
            |......|.||........||.. :..:.:.:.|.|..:.||.|.: |.|:.|.:|.||:.| :|
Human   570 ECGLLGFVLDLKQDYEPVRSQMP-EEKLYKVYTFNSVRKSMSTVIK-LPDESFRMYSKGASEIVL 632

  Fly   810 KKLCK------------PQSLPDNYSQQLSEFAKKGYRIIAIAFKAL--SHKMNYTKVQRLSREE 860
            ||.||            |:...:...:.:...|..|.|.|.:|::..  |.:.::.     :..:
Human   633 KKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWD-----NEND 692

  Fly   861 VENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITV 925
            :.|.:..:..|.:|:.::|:..:.|.....|.|...|:|||||.||.::|..|||:.|.:
Human   693 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE----- 752

  Fly   926 HADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTA 990
                                                                         :|..
Human   753 -------------------------------------------------------------DFLC 756

  Fly   991 QVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQEC 1055
            ..||     |....:.||.                            .|:           .||.
Human   757 LEGK-----EFNRRIRNEK----------------------------GEI-----------EQER 777

  Fly  1056 IFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALV---IELQNLD--YCVAMCGDGAN 1115
            |    .|.|..::               :.||.||..|..||   |:..:.:  ..||:.|||.|
Human   778 I----DKIWPKLR---------------VLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTN 823

  Fly  1116 DCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLV 1177
            |..|||.|..|.::......:   ||.....:...|:::|.:..||....:   |.|::.....|
Human   824 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTV 885

  Fly  1178 QFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISS 1234
            ..::|::.:     :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   ..|||.
Human   886 NVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTETLLLRKPYGRNKPLISR 949

  Fly  1235 TPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFS 1299
            |.:.::|.|.....|...|.                      .|....||.|.|          .
Human   950 TMMKNILGHAVYQLALIFTL----------------------LFVGEKMFQIDS----------G 982

  Fly  1300 KGAPYRKPLWSNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFR 1351
            :.||...|...::.:    |.|..:::.|.             ::...:....|..||..|...:
Human   983 RNAPLHSPPSEHYTI----IFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQ 1043

  Fly  1352 YVMLAYGAASFIC 1364
            .|::.:|...|.|
Human  1044 IVIVQFGGKPFSC 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	243/1237 (20%)
		E1-E2_ATPase	381..621	CDD:278548	71/359 (20%)
		Cation_ATPase	<758..813	CDD:289987	17/55 (31%)
		HAD_like	<1087..1137	CDD:304363	19/57 (33%)
ATP2B2	XP_016861981.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930