Protein Alignment anne and ATP2B1

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001353453.1
• Gene: ATP2B1 / 490
• HGNCID: 814
• Length: 1249
• Species: Homo sapiens
• Alignment Length: 1217
• Identity: 242/1217 - (19%)
• Similarity: 399/1217 - (32%)
• Gaps: 422/1217 - (34%)

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYY---------------- 376
            |..|||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|
Human    81 REAVFGKN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVG 143

  Fly   377 ----------YYACVILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVVDH 419
                      .....|||..|..:.|:.            ||::..|:  ||        :.|..
Human   144 EEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQE--QK--------FTVIR 198

  Fly   420 KGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDMI 483
            .|...::|...|..|||.:: ..|..|..|.|||.||.: :|||.|||||..|.|:
Human   199 GGQVIQIPVADITVGDIAQV-KYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS--------- 253

  Fly   484 FDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNIT--------AKGELIR----------- 529
            .||..    .|..||.|::    ||.:::...:...:.|        |.||...
Human   254 LDKDP----LLLSGTHVME----GSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKN 310

  Fly   530 ------------------SILYPPPVDYK-----FEQDSYKF-------------IQFLAI-IAC 557
                              :.:...|:..:     .|:|..|.             :..||: |..
Human   311 KKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGK 375

  Fly   558 VGFIYTLVTKI------------------LRGTDP------VKIAVESLDLITIVVPPALPAAMT 598
            .|.:.:.:|.|                  |....|      ||..:..:.::.:.||..||.|:|
Human   376 AGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVT 440

  Fly   599 VGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKS 663
            :...|:.|::...........:....|:....|.|||||||         :.:.:..|..|..|.
Human   441 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT---------MNRMTVVQAYINEKH 496

  Fly   664 VDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQ 728
            ..::|....:                   |.::..:..||    .|.|...|.|  ||.|    :
Human   497 YKKVPEPEAI-------------------PPNILSYLVTG----ISVNCAYTSK--ILPP----E 532

  Fly   729 PRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFP---------FTSALQ 784
            ..|||    ....|:|.|          .|.:|:....|.....:..|.|         |.|..:
Human   533 KEGGL----PRHVGNKTE----------CALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRK 583

  Fly   785 RMSVVTRCLSDQVFNVYCKGSPEMLKKLC-------------KPQSLPDNYSQQLSEFAKKGYRI 836
            .||.|.: .||..:.::.||:.|::.|.|             :|:...|.....:...|.:|.|.
Human   584 SMSTVLK-NSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRT 647

  Fly   837 IAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGD 901
            |.:||:  .......:.:..:..::...:..:..|.:|:.::|:....|.....|.|...|:|||
Human   648 ICLAFR--DFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGD 710

  Fly   902 NILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKT 966
            ||.||.::|..|||:.|.:..:.:.....  :..|:...|     :...::..|:...|.:.:::
Human   711 NINTARAIATKCGILHPGEDFLCLEGKDF--NRRIRNEKG-----EIEQERIDKIWPKLRVLARS 768

  Fly   967 SRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTID 1031
            |                                                   ||.
Human   769 S---------------------------------------------------PTD---------- 772

  Fly  1032 TWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQAL 1096
                       |||                                 |.:|.|.:.:| ||:|.
Human   773 -----------KHT---------------------------------LVKGIIDSTVS-DQRQV- 791

  Fly  1097 VIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGR 1158
                      ||:.|||.||..|||.|..|.::......:   ||.....:...::::|.:..||
Human   792 ----------VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGR 846

  Fly  1159 AALVTSFGIFKYMAAYSLVQFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESF 1218
            ....:   |.|::.....|..::|::.:     :.||.|...|.|:|:| ::...|.....||..
Human   847 NVYDS---ISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTLASLALATEPP 907

  Fly  1219 DGMLVEQVPL---SSLISSTPLASLLLH--LTVVTAFQVTCWVHLHQQPWFKAFEPADED----- 1273
            ...|:.:.|.   ..|||.|.:.::|.|  ..:|..|.:.          |...:..|.|
Human   908 TESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLL----------FAGEKFFDIDSGRNA 962

  Fly  1274 --HLGCFENYTMFCISSFQYIILAFVFSKGAPYRK---------PLWSNWPLCL----AFIVNLC 1323
              |....|:||:.    |...:|..:|:: ...||         .:::|...|.    .|:|.:.
Human   963 PLHAPPSEHYTIV----FNTFVLMQLFNE-INARKIHGERNVFEGIFNNAIFCTIVLGTFVVQII 1022

  Fly  1324 IIVY-------LVLYPSDWVASFF---------QLI-VPPTMRFRYV 1353
            |:.:       ..|....|:.|.|         ||| ..||.|.:::
Human  1023 IVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFL 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	220/1113 (20%)
ATP2B1	NP_001353453.1	ATPase-IIB_Ca	15..1064	CDD:273668	240/1210 (20%)
		ATP_Ca_trans_C	1103..1178	CDD:463575