DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and ATP2B1

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001353453.1	Gene:	ATP2B1 / 490	HGNCID:	814	Length:	1249	Species:	Homo sapiens

Alignment Length:	1217	Identity:	242/1217 - (19%)
Similarity:	399/1217 - (32%)	Gaps:	422/1217 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYY---------------- 376
            |..|||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|
Human    81 REAVFGKN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVG 143

  Fly   377 ----------YYACVILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVVDH 419
                      .....|||..|..:.|:.            ||::..|:  ||        :.|..
Human   144 EEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQE--QK--------FTVIR 198

  Fly   420 KGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDMI 483
            .|...::|...|..|||.:: ..|..|..|.|||.||.: :|||.|||||..|.|:
Human   199 GGQVIQIPVADITVGDIAQV-KYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS--------- 253

  Fly   484 FDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNIT--------AKGELIR----------- 529
            .||..    .|..||.|::    ||.:::...:...:.|        |.||...
Human   254 LDKDP----LLLSGTHVME----GSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKN 310

  Fly   530 ------------------SILYPPPVDYK-----FEQDSYKF-------------IQFLAI-IAC 557
                              :.:...|:..:     .|:|..|.             :..||: |..
Human   311 KKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGK 375

  Fly   558 VGFIYTLVTKI------------------LRGTDP------VKIAVESLDLITIVVPPALPAAMT 598
            .|.:.:.:|.|                  |....|      ||..:..:.::.:.||..||.|:|
Human   376 AGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVT 440

  Fly   599 VGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKS 663
            :...|:.|::...........:....|:....|.|||||||         :.:.:..|..|..|.
Human   441 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT---------MNRMTVVQAYINEKH 496

  Fly   664 VDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQ 728
            ..::|....:                   |.::..:..||    .|.|...|.|  ||.|    :
Human   497 YKKVPEPEAI-------------------PPNILSYLVTG----ISVNCAYTSK--ILPP----E 532

  Fly   729 PRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFP---------FTSALQ 784
            ..|||    ....|:|.|          .|.:|:....|.....:..|.|         |.|..:
Human   533 KEGGL----PRHVGNKTE----------CALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRK 583

  Fly   785 RMSVVTRCLSDQVFNVYCKGSPEMLKKLC-------------KPQSLPDNYSQQLSEFAKKGYRI 836
            .||.|.: .||..:.::.||:.|::.|.|             :|:...|.....:...|.:|.|.
Human   584 SMSTVLK-NSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRT 647

  Fly   837 IAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGD 901
            |.:||:  .......:.:..:..::...:..:..|.:|:.::|:....|.....|.|...|:|||
Human   648 ICLAFR--DFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGD 710

  Fly   902 NILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKT 966
            ||.||.::|..|||:.|.:..:.:.....  :..|:...|     :...::..|:...|.:.:::
Human   711 NINTARAIATKCGILHPGEDFLCLEGKDF--NRRIRNEKG-----EIEQERIDKIWPKLRVLARS 768

  Fly   967 SRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTID 1031
            |                                                   ||.
Human   769 S---------------------------------------------------PTD---------- 772

  Fly  1032 TWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQAL 1096
                       |||                                 |.:|.|.:.:| ||:|.
Human   773 -----------KHT---------------------------------LVKGIIDSTVS-DQRQV- 791

  Fly  1097 VIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGR 1158
                      ||:.|||.||..|||.|..|.::......:   ||.....:...::::|.:..||
Human   792 ----------VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGR 846

  Fly  1159 AALVTSFGIFKYMAAYSLVQFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESF 1218
            ....:   |.|::.....|..::|::.:     :.||.|...|.|:|:| ::...|.....||..
Human   847 NVYDS---ISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTLASLALATEPP 907

  Fly  1219 DGMLVEQVPL---SSLISSTPLASLLLH--LTVVTAFQVTCWVHLHQQPWFKAFEPADED----- 1273
            ...|:.:.|.   ..|||.|.:.::|.|  ..:|..|.:.          |...:..|.|
Human   908 TESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLL----------FAGEKFFDIDSGRNA 962

  Fly  1274 --HLGCFENYTMFCISSFQYIILAFVFSKGAPYRK---------PLWSNWPLCL----AFIVNLC 1323
              |....|:||:.    |...:|..:|:: ...||         .:::|...|.    .|:|.:.
Human   963 PLHAPPSEHYTIV----FNTFVLMQLFNE-INARKIHGERNVFEGIFNNAIFCTIVLGTFVVQII 1022

  Fly  1324 IIVY-------LVLYPSDWVASFF---------QLI-VPPTMRFRYV 1353
            |:.:       ..|....|:.|.|         ||| ..||.|.:::
Human  1023 IVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFL 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	242/1217 (20%)
		E1-E2_ATPase	381..621	CDD:278548	69/332 (21%)
		Cation_ATPase	<758..813	CDD:289987	16/63 (25%)
		HAD_like	<1087..1137	CDD:304363	16/52 (31%)
ATP2B1	NP_001353453.1	ATPase-IIB_Ca	15..1064	CDD:273668	240/1210 (20%)
ATP2B1	NP_001353453.1	ATP_Ca_trans_C	1103..1178	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930