DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and ATP2A2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_733765.1	Gene:	ATP2A2 / 488	HGNCID:	812	Length:	1042	Species:	Homo sapiens

Alignment Length:	1151	Identity:	246/1151 - (21%)
Similarity:	394/1151 - (34%)	Gaps:	358/1151 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HQQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFS---------------V 367
            ::..||.:.:....:..:|.||:  |..:.||||.|       |.:.|.               |
Human    19 NESTGLSLEQVKKLKERWGSNEL--PAEEGKTLLEL-------VIEQFEDLLVRILLLAACISFV 74

  Fly   368 ILWF-----TYDYYYYACVILLMSVFGITVSVLQTKKNQ---DVLQKTVYNTGNAWVVDHKGLSK 424
            :.||     |...:....||||:.|....|.|.|.:..:   :.|::.....|..:..|.|.:.:
Human    75 LAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQR 139

  Fly   425 ELPTRAIVPGDIIEIPSSGCTLHCDAILI---SGNCILDESMLTGESVPVTK--TPLPSKRDMIF 484
             :..:.||||||:|| :.|..:..|..|.   |....:|:|:||||||.|.|  .|:|..|.:..
Human   140 -IKAKDIVPGDIVEI-AVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQ 202

  Fly   485 DKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKG----ELIRSILYPPPVDYKFEQDS 545
            ||    ::.||.||.      |.:.|.:..|:.||..|..|    |::.:.....|:..|.::..
Human   203 DK----KNMLFSGTN------IAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFG 257

  Fly   546 YKFIQFLAIIACVGFIYTLVTKILRGTDPV-------------KIAVESLDLITIVVPPALPAAM 597
            .:..:.:::| |:.   ..:..|....|||             ||||.   |....:|..|||.:
Human   258 EQLSKVISLI-CIA---VWIINIGHFNDPVHGGSWIRGAIYYFKIAVA---LAVAAIPEGLPAVI 315

  Fly   598 TVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVV-------PKSSTN 655
            |.......:|:........|..|:...|..:..|.|||||||.:.:.:..:.       ...|.|
Human   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLN 380

  Fly   656 QFQI------PLKSV--DRLPFD-HFLFGMVTCHSITILNGRMMGDPLDLK-MFESTGWELE--- 707
            :|.|      |:..|  |..|.: |...|:|...:|..|......|..:.| ::|..|...|
Human   381 EFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETAL 445

  Fly   708 ----DSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKN 768
                :..|:.|||..|:                        ::|:|.::.:.::..:
Human   446 TCLVEKMNVFDTELKGL------------------------SKIERANACNSVIKQL-------- 478

  Fly   769 FDHGIVREFPFTSALQRMSVVTRCLSDQ-----VFNVYCKGSPEMLKKLC-------KPQSLPDN 821
                :.:||....:..|.|:...|..::     :..::.||:||.:...|       ....:...
Human   479 ----MKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSG 539

  Fly   822 YSQQLSEFAKK------GYRIIAIAFKALSHKMNYTKVQRLSREEV-----------ENNMEFLG 869
            ..|::....::      ..|.:|:|          |....|.|||:           |.|:.|:|
Human   540 VKQKIMSVIREWGSGSDTLRCLALA----------THDNPLRREEMHLEDSANFIKYETNLTFVG 594

  Fly   870 FVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSA 934
            .|.:.:..:.:....:.....|.||.|||||||..||:::.|..||....:.|
Human   595 CVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDV------------ 647

  Fly   935 NIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHM 999
                                           ||:|      |....||...|
Human   648 -------------------------------TSKA------FTGREFDELNP------------- 662

  Fly  1000 ESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTW 1064
                                                             |.:|..|:.|
Human   663 -------------------------------------------------SAQRDACLNA------ 672

  Fly  1065 QIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISL 1129
                              ..:||:.|..|..:|..||:.|...||.|||.||..|||.|..||::
Human   673 ------------------RCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAM 719

  Fly  1130 SE--TEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSI--DS 1190
            ..  ..|..||.....:...|.::..::||||.........:|:.:.::.:.:.:.:..::  ..
Human   720 GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPE 784

  Fly  1191 NLTDKQYLYVDLGLISIFAFFFG-KTESFDGM-LVEQVPLSSLISSTPLASLLLHLTVVTAFQV- 1252
            .|...|.|:|:|....:.|...| .....|.| ...:.|...|||.......|.....|.|..|
Human   785 ALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVG 849

  Fly  1253 -TCWVHLHQQPWFKA--------------FEPADEDH-----LGC--FEN-YTMFCISSFQYII- 1293
             ..|       ||.|              |....||:     :.|  ||: |.|....|....|
Human   850 AAAW-------WFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIE 907

  Fly  1294 ----LAFVFSKGAPYRKPLWSN-W---PLCLAFIVNLCIIVYLVLY 1331
                |..:....:..|.|.|.| |   .:||:..::     :|:||
Human   908 MCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLH-----FLILY 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	246/1151 (21%)
		E1-E2_ATPase	381..621	CDD:278548	71/264 (27%)
		Cation_ATPase	<758..813	CDD:289987	9/59 (15%)
		HAD_like	<1087..1137	CDD:304363	21/51 (41%)
ATP2A2	NP_733765.1	Cation_ATPase_N	4..72	CDD:279080	13/61 (21%)
		ATPase-IIA1_Ca	53..988	CDD:273452	235/1108 (21%)
		E1-E2_ATPase	93..340	CDD:278548	72/265 (27%)
		Cation_ATPase	419..527	CDD:289987	23/143 (16%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:18971376	575..594		3/18 (17%)
		HAD	<605..711	CDD:289480	43/240 (18%)
		Cation_ATPase_C	783..986	CDD:279079	42/178 (24%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		5/19 (26%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250\|UniProtKB:O55143	788..1042		41/173 (24%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840