DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and ATP2A1

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_775293.1	Gene:	ATP2A1 / 487	HGNCID:	811	Length:	1001	Species:	Homo sapiens

Alignment Length:	1174	Identity:	251/1174 - (21%)
Similarity:	386/1174 - (32%)	Gaps:	420/1174 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 EQISRRI-VFGDNEITVPLRDFKTL--LFLEVLNPFYVFQLF------SVILWF-----TYDYYY 377
            :|:.|.: .:|.||:  |..:.|||  |.:|......|..|.      .|:.||     |...:.
Human    27 DQVKRNLEKYGLNEL--PAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFV 89

  Fly   378 YACVILLMSVFGITVSVLQTKKNQ---DVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEI 439
            ...||||:.:....|.|.|.:..:   :.|::.....|..:..|.|.:.: :..|.||||||:|:
Human    90 EPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQR-IKARDIVPGDIVEV 153

  Fly   440 PSSGCTLHCDAILI---SGNCILDESMLTGESVPVTK--TPLPSKRDMIFDKTEHARHTLFCGTK 499
             :.|..:..|..::   |....:|:|:||||||.|.|  .|:|..|.:..||    ::.||.||.
Human   154 -AVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDK----KNMLFSGTN 213

  Fly   500 VIQTRYIGSKKVLAFVINTGNITAKGELIRSILY-----PPPVDYKFEQDSYKFIQFLAIIACVG 559
                  |.:.|.|..|..||..|..|: ||..:.     ..|:..|.::...:..:.:::| ||.
Human   214 ------IAAGKALGIVATTGVGTEIGK-IRDQMAATEQDKTPLQQKLDEFGEQLSKVISLI-CVA 270

  Fly   560 FIYTLVTKILRGTDPV-------------KIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTS 611
               ..:..|....|||             ||||.   |....:|..|||.:|.......:|:...
Human   271 ---VWLINIGHFNDPVHGGSWFRGAIYYFKIAVA---LAVAAIPEGLPAVITTCLALGTRRMAKK 329

  Fly   612 EIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGM 676
            .....|..|:...|..:..|.|||||||              |||                   |
Human   330 NAIVRSLPSVETLGCTSVICSDKTGTLT--------------TNQ-------------------M 361

  Fly   677 VTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPR----GGLSGMA 737
            ..|....|  .::.||...|..|..||     |...|:.|        :|:..:    |...|:.
Human   362 SVCKMFII--DKVDGDICLLNEFSITG-----STYAPEGE--------VLKNDKPVRPGQYDGLV 411

  Fly   738 ETESGSKNEIKRQSSVDDLLATVGISPSQKNFDH----------GIVREFPFTSALQRMSV---- 788
            |                  |||:....:..:.|.          |...|...|:.:::|:|
Human   412 E------------------LATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTD 458

  Fly   789 ---------------VTRCLSDQVF-----------NVYC----------------KGSPEMLKK 811
                           |.|.|..:.|           :|||                ||:||.:..
Human   459 VRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVID 523

  Fly   812 LCK---------PQSLP--DNYSQQLSEF--AKKGYRIIAIAFKALSHKMNYTKVQRLSR-EEVE 862
            .|.         |.:.|  :.....:.|:  .:...|.:|:|.:....|.....:...:| .|.|
Human   524 RCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYE 588

  Fly   863 NNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHA 927
            .::.|:|.|.:.:..:.:.|..|.....|.||.|||||||..|||::.|..||...::.|    |
Human   589 TDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEV----A 649

  Fly   928 DPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQV 992
            |        :..||.|  ||:
Human   650 D--------RAYTGRE--FDD-------------------------------------------- 660

  Fly   993 GKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIF 1057
                                     ||.::                            :|:.|
Human   661 -------------------------LPLAE----------------------------QREAC-- 670

  Fly  1058 AMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKV 1122
                                  .|...:||:.|..|..:|..||:.|...||.|||.||..|||.
Human   671 ----------------------RRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKK 713

  Fly  1123 AHAGISLSE--TEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMI- 1184
            |..||::..  ..|..||.....:...|.::..::||||.........:|:.:.::.:.:.:.:
Human   714 AEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLT 778

  Fly  1185 -LYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLAS--LLLHLTV 1246
             ...:...|...|.|:|:|....:.|...|.... |..::::.|.|   ...||.|  |......
Human   779 AALGLPEALIPVQLLWVNLVTDGLPATALGFNPP-DLDIMDRPPRS---PKEPLISGWLFFRYMA 839

  Fly  1247 VTAF------QVTCWVHLHQQPWFKAFEPADEDHLG---------CFENYTMF----CISSFQYI 1292
            :..:      ....|       ||...|  |..|:.         |.|:.|.|    |
Human   840 IGGYVGAATVGAAAW-------WFLYAE--DGPHVNYSQLTHFMQCTEDNTHFEGIDC------- 888

  Fly  1293 ILAFVFSKGAP--------------------------YRKPLWSN-W---PLCLAFIVNLCIIVY 1327
               .||....|                          .|.|.|.| |   .:||:..::     :
Human   889 ---EVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLH-----F 945

  Fly  1328 LVLY 1331
            |:||
Human   946 LILY 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	251/1174 (21%)
		E1-E2_ATPase	381..621	CDD:278548	72/265 (27%)
		Cation_ATPase	<758..813	CDD:289987	19/110 (17%)
		HAD_like	<1087..1137	CDD:304363	21/51 (41%)
ATP2A1	NP_775293.1	Cation_ATPase_N	4..72	CDD:279080	13/46 (28%)
		ATPase-IIA1_Ca	53..989	CDD:273452	241/1146 (21%)
		E1-E2_ATPase	93..340	CDD:278548	73/266 (27%)
		Cation_ATPase	419..528	CDD:289987	18/108 (17%)
		HAD	<611..712	CDD:289480	46/235 (20%)
		Cation_ATPase_C	784..987	CDD:279079	38/194 (20%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		5/19 (26%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910