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Protein Alignment anne and ATP1A4

DIOPT Version :10

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_653300.2	Gene:	ATP1A4 / 480	HGNCID:	14073	Length:	1029	Species:	Homo sapiens

Alignment Length:	1197	Identity:	241/1197 - (20%)
Similarity:	401/1197 - (33%)	Gaps:	388/1197 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 QQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFL----------EVL-------------NPFY 360
            |:|.:   |::.:.:|..|:::|:.....|..:.|          |:|             .|.:
Human    36 QKRNM---EELKKEVVMDDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEW 97

  Fly   361 V------FQLFSVILWF-------------------TYDYYYYACVILLMSVFGITVSVLQTKKN 400
            |      |..||::||.                   |.|..|.:.|:.::.:.....|..|..|:
Human    98 VKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKS 162

  Fly   401 QDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISG-NCILDESML 464
            ..:::..........:|...|...::..:.:|.||::|| ..|..:..|..|||. .|.:|.|.|
Human   163 SKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEI-KGGDRVPADLRLISAQGCKVDNSSL 226

  Fly   465 TGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIR 529
            ||||.|.:::|     |...:.....|:..|..|..::    |:.:  ..||.||:.|..|. |.
Human   227 TGESEPQSRSP-----DFTHENPLETRNICFFSTNCVE----GTAR--GIVIATGDSTVMGR-IA 279

  Fly   530 SI-----LYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVV 589
            |:     :...|:..:.|.    ||..:.::|....:......:|.|...::..:..:.:|...|
Human   280 SLTSGLAVGQTPIAAEIEH----FIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANV 340

  Fly   590 PPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSST 654
            |..|.|.:||......||:........:..::...||.:..|.|||||||:
Human   341 PEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQ-------------- 391

  Fly   655 NQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSN--------- 710
                      :|:...|..|.|....:.|              ..|.||.....|:
Human   392 ----------NRMTVAHMWFDMTVYEADT--------------TEEQTGKTFTKSSDTWFMLARI 432

  Fly   711 ----NIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQ-SSVDDLLATVGISPSQKNFD 770
                |..|.:....:.|...|...|..|     ||.....|::. |||.::        .:||
Human   433 AGLCNRADFKANQEILPIAKRATTGDAS-----ESALLKFIEQSYSSVAEM--------REKN-- 482

  Fly   771 HGIVREFPFTSALQ-RMSVVTRCLSDQVFNVYCKGSPEMLKKLC-------KPQSLPDNYSQQLS 827
             ..|.|.||.|..: :||:..|..|.|...:..||:||.:.:.|       :..|:.|...:...
Human   483 -PKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQ 546

  Fly   828 ----EFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL 888
                |....|.|::...|  |:...:::|....:.:|:...|:.|.||.|.:.:.|....|.:|:
Human   547 NAYLELGGLGERVLGFCF--LNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAV 609

  Fly   889 N---AAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSS 950
            :   :|.|:.||:|||:.:||.::|:..||:|..    |..|:.:.....|..:     ..|.|:
Human   610 SKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEG----TETAEEVAARLKIPIS-----KVDASA 665

  Fly   951 DKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAE 1015
            .|...:|                                   |..:..::|
Human   666 AKAIVVH-----------------------------------GAELKDIQS-------------- 681

  Fly  1016 SGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLT 1080
                        |.:|....|..|:
Human   682 ------------KQLDQILQNHPEI---------------------------------------- 694

  Fly  1081 RGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTS 1142
               ::||.||.||..:|...|.|...||:.|||.||..|||.|..||::..:.:.:   |:....
Human   695 ---VFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMIL 756

  Fly  1143 RNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFIS------VMILYSIDSNLTDKQYLYVD 1201
            .:...::::..::|||..    |...|....|:|...|.      :.|:..|...|.....|.:|
Human   757 LDDNFASIVTGVEEGRLI----FDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCID 817

  Fly  1202 LG--LISIFAFFFGKTES-------------------FDGMLVEQVPLSSLISS----------- 1234
            ||  ::...:..:...||                   ..||...|:.:...::.
Human   818 LGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAEN 882

  Fly  1235 ----TPLASLLLH--------------------------LTVVTAFQVTC----WVHL-----HQ 1260
                ..|..:.||                          .|..|||.||.    |..|     .:
Human   883 GFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRR 947

  Fly  1261 QPWFK--------AFEPADEDHLGCFENYTM-FCISSFQYIILAFVFSKGAPYRKPLWSNWPLCL 1316
            ...|:        .|...:|..|..|.:||. ..::...|               ||...|.||
Human   948 NSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMY---------------PLKITWWLC- 996

  Fly  1317 AFIVNLCIIVY-----LVL--YPSDWV 1336
            |...::.|.||     |::  :|..||
Human   997 AIPYSILIFVYDEIRKLLIRQHPDGWV 1023

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.