Protein Alignment anne and ATP12A

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001172014.1
• Gene: ATP12A / 479
• HGNCID: 13816
• Length: 1045
• Species: Homo sapiens
• Alignment Length: 1207
• Identity: 240/1207 - (19%)
• Similarity: 417/1207 - (34%)
• Gaps: 397/1207 - (32%)

  Fly   297 NNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVF--------------GDNEITVPLRDF 347
            |:...||:...||       .|:.....:.|:....|:.              |.|.:|.|.:..
Human    45 NHKEEFQKELHLD-------DHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTP 102

  Fly   348 KTLLFLEVLNPFYVFQL---FSVILWF-------------------TYDYYYYACVILLMSVFGI 390
            :.:.||:        |:   ||::||.                   :.:..|..||:.|:.:...
Human   103 EIVKFLK--------QMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTG 159

  Fly   391 TVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCD-AILIS 454
            ..:..|..|:.:::...........:|......|.:|:..:|.|||:|: ..|..:..| .:|.|
Human   160 IFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEV-KGGDQIPADIRVLSS 223

  Fly   455 GNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQ--TRYIGSKKVLAFVIN 517
            ..|.:|.|.|||||     .|.|...:...:.....::..|..|..::  |..:|:  |...|||
Human   224 QGCRVDNSSLTGES-----EPQPRSSEFTHENPLETKNICFYSTTCLEASTSPVGT--VTGMVIN 281

  Fly   518 TGNITAKGELIRSIL-----YPPPVDYKFEQDSYKFIQFLAIIA-CVGFIYTLVTKILRGTDPVK 576
            ||:.|..|. |.|:.     ...|:..:.|.    |:..:|.:| .:|.::.::.        |.
Human   282 TGDRTIIGH-IASLASGVGNEKTPIAIEIEH----FVHIVAGVAVSIGILFFIIA--------VS 333

  Fly   577 IAVESLD----LITIV---VPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDK 634
            :..:.||    ||.|:   ||..|.|.:||......||:........:..::...||.:..|.||
Human   334 LKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDK 398

  Fly   635 TGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMF 699
            |||||::.:                   :|..|.||:.:|...|..
Human   399 TGTLTQNRM-------------------TVAHLWFDNQIFVADTSE------------------- 425

  Fly   700 ESTGWELEDSNNIPD--TEKYGILYPTILRQPRGGLSGMAETESGSKN-EIKRQSSVDDLLATVG 761
                   :.||.:.|  :..:..|...|.      |...||.:.|.:| .|.:::.:.|...|..
Human   426 -------DHSNQVFDQSSRTWASLSKIIT------LCNRAEFKPGQENVPIMKKAVIGDASETAL 477

  Fly   762 ISPSQ-----------KNFDHGIVREFPFTSALQRMSVVTRCLSD---QVFNVYCKGSPEMLKKL 812
            :..|:           :|..   |.|.||.|. .:..:....:.|   :.|.:..||:||.:.:.
Human   478 LKFSEVILGDVMEIRKRNRK---VAEIPFNST-NKFQLSIHEMDDPHGKRFLMVMKGAPERILEK 538

  Fly   813 CK-----------PQSLPDNYSQQLSEFAKKGYRIIAIAFKALS------------HKMNYTKVQ 854
            |.           .:|....:.....|....|.|::......|.            ..||:.
Human   539 CSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFP--- 600

  Fly   855 RLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPS 919
                   .:|:.|:|.:.:.:..:......:....:|.|:.||:|||:.:||.::|:..||:|
Human   601 -------TSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIIS-- 656

  Fly   920 QSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPE 984
                                    .|.:...|..::|:..::
Human   657 ------------------------ANSETVEDIAHRLNIAVE----------------------- 674

  Fly   985 TPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDES 1049
                  ||.|                          .|:.|:|.|           |::
Human   675 ------QVNK--------------------------RDAKAAVVT-----------GME------ 690

  Fly  1050 WRRQECIFAMDGKTWQIVKDYFPEEMEILLT--RGSIYARMSPDQKQALVIELQNLDYCVAMCGD 1112
                             :||...|:::.:|.  :..::||.||.||..:|...|..|..||:.||
Human   691 -----------------LKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGD 738

  Fly  1113 GANDCGALKVAHAGISL---SETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAY 1174
            |.||..|||.|..||::   ....|..|:.....:...::::..::|||..    |...|...||
Human   739 GVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLI----FDNLKKTIAY 799

  Fly  1175 SLVQFIS------VMILYSIDSNLTDKQYLYVDLG--LISIFAFFFGKTESFDGM---------- 1221
            ||.:.|:      :.|:..:...:.....|::|||  :|...|..:.|.|| |.|
Human   800 SLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAES-DIMNRKPRHKNKD 863

  Fly  1222 -LVEQVPLS-------SLISSTPLASLLLHLTVVT--AFQVTCWVHLHQQPWFKAFEPADEDHLG 1276
             ||.| ||:       .|:.:  |.:.|::.||..  .|.....::|..: |.|.:....:|..|
Human   864 RLVNQ-PLAVYSYLHIGLMQA--LGAFLVYFTVYAQEGFLPRTLINLRVE-WEKDYVNDLKDSYG 924

  Fly  1277 CFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCI--IVYLVLYPSD----- 1334
              :.:|.:   ..:|:                  .|....||.|.:.:  |..|::..:.
Human   925 --QEWTRY---QREYL------------------EWTGYTAFFVGILVQQIADLIIRKTRRNSIF 966

  Fly  1335 ----------WVASFFQLIVPPTMRFRYVMLAYGAAS 1361
                      ||....|:|:.       ::|:||..|
Human   967 QQGLFRNKVIWVGITSQIIIG-------LILSYGLGS 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	218/1079 (20%)
ATP12A	NP_001172014.1	ATPase-IIC_X-K	42..1045	CDD:273445	240/1207 (20%)