Protein Alignment anne and ATP1A2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_000693.1
• Gene: ATP1A2 / 477
• HGNCID: 800
• Length: 1020
• Species: Homo sapiens
• Alignment Length: 1173
• Identity: 235/1173 - (20%)
• Similarity: 387/1173 - (32%)
• Gaps: 404/1173 - (34%)

  Fly   336 GDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKN 400
            |.|.:|.|....:.:.|...|     |..||::||..        .||....:||..::.....|
Human    74 GPNALTPPPTTPEWVKFCRQL-----FGGFSILLWIG--------AILCFLAYGIQAAMEDEPSN 125

  Fly   401 QD-----VLQKTVYNTG---------NAWVVD-------------HKGLSKELPTRAIVPGDIIE 438
            .:     ||...|..||         ::.::|             .:|...::....:|.||::|
Human   126 DNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVE 190

  Fly   439 IPSSGCTLHCDAILISGN-CILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQ 502
            : ..|..:..|..:||.: |.:|.|.|||||.|.|::|     :...:.....|:..|..|..::
Human   191 V-KGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSP-----EFTHENPLETRNICFFSTNCVE 249

  Fly   503 TRYIGSKKVLAFVINTGNITAKG---------ELIRSILYPPPVDYKFEQDSYKFIQFLAIIACV 558
                |:.:  ..||.||:.|..|         |:.|:     |:..:.|.    |||.:..:|..
Human   250 ----GTAR--GIVIATGDRTVMGRIATLASGLEVGRT-----PIAMEIEH----FIQLITGVAVF 299

  Fly   559 GFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINV 623
            ..:...|..::.|...::..:..:.:|...||..|.|.:||......||:........:..::..
Human   300 LGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVET 364

  Fly   624 AGSINCCCFDKTGTLTEDGL---DMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITIL 685
            .||.:..|.|||||||::.:   .||                      ||:
Human   365 LGSTSTICSDKTGTLTQNRMTVAHMW----------------------FDN-------------- 393

  Fly   686 NGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILY----PTILRQPR-GGLSGMAETESGSKN 745
                               ::.:::...|  :.|..:    ||.....| .||...|..::|.:|
Human   394 -------------------QIHEADTTED--QSGATFDKRSPTWTALSRIAGLCNRAVFKAGQEN 437

  Fly   746 -EIKRQSSVDD-----LLATVGIS--PSQKNFDHG-IVREFPFTSALQ-RMSVVTRCLSDQVFNV 800
             .:.::.:..|     ||..:.:|  ..:|..|.. .|.|.||.|..: ::|:..|..|.|...:
Human   438 ISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVL 502

  Fly   801 YCKGSPEMLKKLCK-----------PQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMN----- 849
            ..||:||.:...|.           .:.:.|.:.....|....|.|::...      ::|
Human   503 VMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFC------QLNLPSGK 561

  Fly   850 YTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVAR 911
            :.:..:...:|:....|.|.||.|.:.:.|....|.:|:   .:|.|:.||:|||:.:||.::|:
Human   562 FPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAK 626

  Fly   912 DCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCF 976
            ..||:|...
Human   627 GVGIISEGN-------------------------------------------------------- 635

  Fly   977 NSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELG 1041
                   ||.|..|                       |...:|.|..          ...:|:..
Human   636 -------ETVEDIA-----------------------ARLNIPMSQV----------NPREAKAC 660

  Fly  1042 IKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGS--IYARMSPDQKQALVIELQNLD 1104
            :.|..|                   :||...|:::.:|...:  ::||.||.||..:|...|...
Human   661 VVHGSD-------------------LKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQG 706

  Fly  1105 YCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFG 1166
            ..||:.|||.||..|||.|..||::..:.:.:   |:.....:...::::..::|||..    |.
Human   707 AIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLI----FD 767

  Fly  1167 IFKYMAAYSLVQFIS------VMILYSIDSNLTDKQYLYVDLG---------------------- 1203
            ..|...||:|...|.      :.|:.:|...|.....|.:|||
Human   768 NLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQ 832

  Fly  1204 -------------LISIFAFFFGKTESFDG------MLVEQVPLSSLISSTPL------------ 1237
                         |||:.....|..::..|      :|.|...|.|.:....|
Human   833 PRNSQTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLED 897

  Fly  1238 ---------ASLLLHLTVVTAF----QVTCWVHL----------HQQPW---FKAFEPADEDHLG 1276
                     ...::..|..|||    .|..|..|          .||..   ...|...:|..|.
Human   898 SYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALA 962

  Fly  1277 CFENYTMFCISSFQYIILAFVFSKGAPYRK-PLWSNWPLCLAFIVNLCIIVY-----LVL--YPS 1333
            .|               |::....|...|. ||...|..| ||..:|.|.:|     |:|  ||.
Human   963 AF---------------LSYCPGMGVALRMYPLKVTWWFC-AFPYSLLIFIYDEVRKLILRRYPG 1011

  Fly  1334 DWV 1336
            .||
Human  1012 GWV 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	217/1108 (20%)
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	235/1173 (20%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..231		10/23 (43%)