DRSC/TRiP Functional Genomics Resources

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Protein Alignment anne and ATP1A2

DIOPT Version :9

Sequence 1:NP_001096849.1 Gene:anne / 317815 FlyBaseID:FBgn0052000 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_000693.1 Gene:ATP1A2 / 477 HGNCID:800 Length:1020 Species:Homo sapiens


Alignment Length:1173 Identity:235/1173 - (20%)
Similarity:387/1173 - (32%) Gaps:404/1173 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   336 GDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKN 400
            |.|.:|.|....:.:.|...|     |..||::||..        .||....:||..::.....|
Human    74 GPNALTPPPTTPEWVKFCRQL-----FGGFSILLWIG--------AILCFLAYGIQAAMEDEPSN 125

  Fly   401 QD-----VLQKTVYNTG---------NAWVVD-------------HKGLSKELPTRAIVPGDIIE 438
            .:     ||...|..||         ::.::|             .:|...::....:|.||::|
Human   126 DNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVE 190

  Fly   439 IPSSGCTLHCDAILISGN-CILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQ 502
            : ..|..:..|..:||.: |.:|.|.|||||.|.|::|     :...:.....|:..|..|..::
Human   191 V-KGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSP-----EFTHENPLETRNICFFSTNCVE 249

  Fly   503 TRYIGSKKVLAFVINTGNITAKG---------ELIRSILYPPPVDYKFEQDSYKFIQFLAIIACV 558
                |:.:  ..||.||:.|..|         |:.|:     |:..:.|.    |||.:..:|..
Human   250 ----GTAR--GIVIATGDRTVMGRIATLASGLEVGRT-----PIAMEIEH----FIQLITGVAVF 299

  Fly   559 GFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINV 623
            ..:...|..::.|...::..:..:.:|...||..|.|.:||......||:........:..::..
Human   300 LGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVET 364

  Fly   624 AGSINCCCFDKTGTLTEDGL---DMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITIL 685
            .||.:..|.|||||||::.:   .||                      ||:              
Human   365 LGSTSTICSDKTGTLTQNRMTVAHMW----------------------FDN-------------- 393

  Fly   686 NGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILY----PTILRQPR-GGLSGMAETESGSKN 745
                               ::.:::...|  :.|..:    ||.....| .||...|..::|.:|
Human   394 -------------------QIHEADTTED--QSGATFDKRSPTWTALSRIAGLCNRAVFKAGQEN 437

  Fly   746 -EIKRQSSVDD-----LLATVGIS--PSQKNFDHG-IVREFPFTSALQ-RMSVVTRCLSDQVFNV 800
             .:.::.:..|     ||..:.:|  ..:|..|.. .|.|.||.|..: ::|:..|..|.|...:
Human   438 ISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVL 502

  Fly   801 YCKGSPEMLKKLCK-----------PQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMN----- 849
            ..||:||.:...|.           .:.:.|.:.....|....|.|::...      ::|     
Human   503 VMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFC------QLNLPSGK 561

  Fly   850 YTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVAR 911
            :.:..:...:|:....|.|.||.|.:.:.|....|.:|:   .:|.|:.||:|||:.:||.::|:
Human   562 FPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAK 626

  Fly   912 DCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCF 976
            ..||:|...                                                        
Human   627 GVGIISEGN-------------------------------------------------------- 635

  Fly   977 NSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELG 1041
                   ||.|..|                       |...:|.|..          ...:|:..
Human   636 -------ETVEDIA-----------------------ARLNIPMSQV----------NPREAKAC 660

  Fly  1042 IKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGS--IYARMSPDQKQALVIELQNLD 1104
            :.|..|                   :||...|:::.:|...:  ::||.||.||..:|...|...
Human   661 VVHGSD-------------------LKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQG 706

  Fly  1105 YCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFG 1166
            ..||:.|||.||..|||.|..||::..:.:.:   |:.....:...::::..::|||..    |.
Human   707 AIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLI----FD 767

  Fly  1167 IFKYMAAYSLVQFIS------VMILYSIDSNLTDKQYLYVDLG---------------------- 1203
            ..|...||:|...|.      :.|:.:|...|.....|.:|||                      
Human   768 NLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQ 832

  Fly  1204 -------------LISIFAFFFGKTESFDG------MLVEQVPLSSLISSTPL------------ 1237
                         |||:.....|..::..|      :|.|...|.|.:....|            
Human   833 PRNSQTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLED 897

  Fly  1238 ---------ASLLLHLTVVTAF----QVTCWVHL----------HQQPW---FKAFEPADEDHLG 1276
                     ...::..|..|||    .|..|..|          .||..   ...|...:|..|.
Human   898 SYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALA 962

  Fly  1277 CFENYTMFCISSFQYIILAFVFSKGAPYRK-PLWSNWPLCLAFIVNLCIIVY-----LVL--YPS 1333
            .|               |::....|...|. ||...|..| ||..:|.|.:|     |:|  ||.
Human   963 AF---------------LSYCPGMGVALRMYPLKVTWWFC-AFPYSLLIFIYDEVRKLILRRYPG 1011

  Fly  1334 DWV 1336
            .||
Human  1012 GWV 1014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
anneNP_001096849.1 P5-ATPase 158..291 CDD:289194
P-ATPase-V 173..1355 CDD:273738 235/1173 (20%)
E1-E2_ATPase 381..621 CDD:278548 60/276 (22%)
Cation_ATPase <758..813 CDD:289987 16/58 (28%)
HAD_like <1087..1137 CDD:304363 20/52 (38%)
ATP1A2NP_000693.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
ATPase-IIC_X-K 30..1020 CDD:273445 235/1173 (20%)
Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250 80..82 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..231 10/23 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141080
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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