DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and PMCA

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	198/1062 - (18%)
Similarity:	350/1062 - (32%)	Gaps:	350/1062 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 RRIVFGDNEI-TVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYY---------------YYA 379
            ||..||.|.| ..|.:.|.||::..:.:...:....:.::.....:|               ::.
  Fly    64 RRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHG 128

  Fly   380 CVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHK------GLSKELPTRAIVPGDIIE 438
            .:..|..:..:.|.|:.|..|....::......|....:||      |...::....|:.|||.:
  Fly   129 WIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQ 193

  Fly   439 I------PSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFC 496
            :      |:.||       ||..|.: :|||.|||||..|.|.  |....|:...|    |.:..
  Fly   194 VKYGDLLPADGC-------LIQSNDLKVDESSLTGESDHVKKG--PDVDPMVLSGT----HVMEG 245

  Fly   497 GTKVIQTRY-IGSKKVLAFVI-------------------------------NTGNITAKG---- 525
            ..|::.|.. :.|:..:.|.:                               |.|....||
  Fly   246 SGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAP 310

  Fly   526 ---ELIRSILYPPPVD----------------YKFEQD--SYKFIQFLAIIACVGFIYTLVTKIL 569
               |.:.|.:.....:                :|.|:.  ..|..:....|...|....::|.|:
  Fly   311 SQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVII 375

  Fly   570 --------------------RGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIF 614
                                ...:.||..:..:.::.:.||..||.|:|:...|:.|::......
  Fly   376 LIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNL 440

  Fly   615 CISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVT- 678
            .....:....|:....|.|||||||.:.:.   ||......:....|.::..:|  ..:..::|
  Fly   441 VRHLDACETMGNATAICSDKTGTLTTNRMT---VVQSYICEKLCKVLPTLSDIP--QHVGNLITM 500

  Fly   679 ------CHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMA 737
                  .::..|:.|...|| |.:::...|...|                       .|.:.|:.
  Fly   501 GISVNSAYTSNIMAGHNPGD-LPIQVGNKTECAL-----------------------LGFVQGLG 541

  Fly   738 ETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRM-SVVTRCLSDQVFNVY 801
                     :|.||..|::        ::..|    .|.:.|.|..:.| :|:.|  .:..:.:|
  Fly   542 ---------VKYQSIRDEI--------TEDKF----TRVYTFNSVRKSMGTVIPR--PNGGYRLY 583

  Fly   802 CKGSPEMLKKLCK----PQSLPDNYSQQLSE---------FAKKGYRIIAIAF------KALSHK 847
            .||:.|::.|.|.    .:...:.:::.:.|         .|..|.|.|::|:      ||..::
  Fly   584 TKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINE 648

  Fly   848 MNYTKVQRLSREE-VENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVAR 911
            ::.........|| :..|:..|..|.:|:.::|:....|.....|.|...|:|||||.||.|:|.
  Fly   649 VHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIAS 713

  Fly   912 DCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCF 976
            .|||:.|:...:.:
  Fly   714 KCGILRPNDDFLIL--------------------------------------------------- 727

  Fly   977 NSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELG 1041
                   |..||..::                            .||...::
  Fly   728 -------EGKEFNRRI----------------------------RDSNGDIQ------------- 744

  Fly  1042 IKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIEL------ 1100
             :|..|:.|.:..                             :.||.||..|..||..:
  Fly   745 -QHLIDKVWPKLR-----------------------------VLARSSPTDKYTLVKGIIDSTVS 779

  Fly  1101 QNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALV 1162
            :|.: .||:.|||.||..|||.|..|.::......:   ||.....:...|:::|.:..||....
  Fly   780 ENRE-VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYD 843

  Fly  1163 TSFGIFKYMAAYSLVQFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGML 1222
            :   |.|::.....|..::|::.:     ..||.|...|.|:|:| ::...|.....||.....|
  Fly   844 S---IAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNL-IMDTLASLALATEFPTPDL 904

  Fly  1223 VEQVP---LSSLISSTPLASLL 1241
            :.:.|   ...|||.|.:.::|
  Fly   905 LLRKPYGRTKPLISRTMMKNIL 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	198/1062 (19%)
		E1-E2_ATPase	381..621	CDD:278548	60/329 (18%)
		Cation_ATPase	<758..813	CDD:289987	12/55 (22%)
		HAD_like	<1087..1137	CDD:304363	19/58 (33%)
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	198/1062 (19%)
		Cation_ATPase_N	36..104	CDD:279080	10/39 (26%)
		E1-E2_ATPase	172..448	CDD:278548	52/288 (18%)
		Cation_ATPase	505..598	CDD:289987	26/139 (19%)
		HAD_like	676..807	CDD:119389	47/260 (18%)
		Cation_ATPase_C	873..1051	CDD:279079	16/55 (29%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930