DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment anne and atp2b3a

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_005166875.1	Gene:	atp2b3a / 436745	ZFINID:	ZDB-GENE-040718-174	Length:	1299	Species:	Danio rerio

Alignment Length:	1250	Identity:	249/1250 - (19%)
Similarity:	396/1250 - (31%)	Gaps:	477/1250 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY------YACV----- 381
            ||.|||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|.      .|||
Zfish    81 RRKVFGMN--FIPPKQPKTFLELVWEALQDITLIILEIAAIISLGLSFYQPPGGDSEACVEVSEG 143

  Fly   382 ----------------ILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVVD 418
                            |||..:..:.|:.            ||::..|:.....|   .|:.|:
Zfish   144 AEDEGEADANWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQRFAVV---RNSTVI- 204

  Fly   419 HKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDM 482
                  ::|...:|.|||.:: ..|..|..|.:||.||.: :|||.|||||..|.|:
Zfish   205 ------QIPVAEMVVGDIAQV-KYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKS-------- 254

  Fly   483 IFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNIT-------AKGELIRSILYPPPVDYK 540
             .||..    .|..||.|::    ||.|:|...:...:.|       ..||:...     ..|.|
Zfish   255 -IDKDP----MLLSGTHVME----GSGKMLVTAVGVNSQTGIIFTLLGAGEMEEE-----KKDCK 305

  Fly   541 FEQDSYKFIQF------------------------------------------------------ 551
            .|.:|....||
Zfish   306 KEVNSNSSTQFPSVEAKEHNIINGKQDGTLENNQNKAKKQDEAVAMEMQPLKSAEGGEVEEKEKK 370

  Fly   552 ------------------LAI-IACVGFIYTLVTKI------------------LRGTDP----- 574
                              ||: |...|.:.:.:|.|                  |....|
Zfish   371 KASVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILMLYFVIKTFIVHKQPWLTECTPIYVQY 435

  Fly   575 -VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTL 638
             ||..:..:.::.:.||..||.|:|:...|:.|::...........:....|:....|.||||||
Zfish   436 FVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 500

  Fly   639 TEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTG 703
            |.:.:.   ||.....:|....:.:.|::                        :|..|::..|.
Zfish   501 TTNRMT---VVQIYIGDQLFRDIPTPDQI------------------------NPRTLELISSA- 537

  Fly   704 WELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKN 768
                .:.|...|.|   :.|.   ...|||    ..:.|:|.|          .|.:|:....|.
Zfish   538 ----IAVNCAYTSK---IMPA---DKEGGL----PKQVGNKTE----------CALLGLVLDLKQ 578

  Fly   769 FDHGIVRE----------FPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLC---------- 813
             |:..|||          :.|.|..:.||.|.: :.|..|.:|.||:.|:|.|.|
Zfish   579 -DYQAVREQIPEELLYKVYTFNSVRKSMSTVIQ-MPDGSFRLYSKGASEILLKKCSFILSRDGEA 641

  Fly   814 ---KPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKM-----NYTKVQRLSREEVENNMEFLGF 870
               :.:...:...:.:...|..|.|.|.||::.|....     |.|        ::.:|:..:..
Zfish   642 RAFRARDKDEMVKKVIEPMACDGLRTICIAYRELPADPLPDWDNET--------DIVSNLTCITV 698

  Fly   871 VILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSAN 935
            |.:|:.::|:....|.....|.|...|:|||||.||.::|..|||:.|            ||
Zfish   699 VGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIHP------------GD--- 748

  Fly   936 IQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHME 1000
                                                               :|....||
Zfish   749 ---------------------------------------------------DFLCMEGK------ 756

  Fly  1001 STNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQ 1065
                                                |....|::...|.  .||.|    .|.|.
Zfish   757 ------------------------------------DFNRRIRNEKGEI--EQERI----DKIWP 779

  Fly  1066 IVKDYFPEEMEILLTRGSIYARMSPDQKQAL--------VIELQNLDYCVAMCGDGANDCGALKV 1122
            .::               :.||.||..|..|        |:|.:.:   ||:.|||.||..|||.
Zfish   780 KLR---------------VLARSSPTDKHTLVKGIIDSTVVEQRQV---VAVTGDGTNDGPALKK 826

  Fly  1123 AHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMI 1184
            |..|.::......:   ||.....:...|:::|.:..||....:   |.|::.....|..::|::
Zfish   827 ADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTVNVVAVIV 888

  Fly  1185 LY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISSTPLASLL 1241
            .:     :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   :.|||.|.:.::|
Zfish   889 AFTGACITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTEALLLRKPYGRNNPLISRTMMKNIL 952

  Fly  1242 LHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRK 1306
            .|    ..:|:.....|                  .|....:|.|.|          .:.||...
Zfish   953 GH----AVYQLVIIFTL------------------LFAGERIFDIDS----------GRDAPLHS 985

  Fly  1307 PLWSNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFRYVMLAYG 1358
            |...::.:    |.|..:::.|.             ::...:....|..||..|...:.|::.:|
Zfish   986 PPSEHYTI----IFNTFVLMQLFNEINARKIHGERNVFDGIFSNPIFCSIVLGTFAIQIVIVQFG 1046

  Fly  1359 AASFICH-IFVESFL 1372
            ...|.|. :.||.:|
Zfish  1047 GKPFSCSPLNVEQWL 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	243/1230 (20%)
		E1-E2_ATPase	381..621	CDD:278548	70/377 (19%)
		Cation_ATPase	<758..813	CDD:289987	20/64 (31%)
		HAD_like	<1087..1137	CDD:304363	19/60 (32%)
atp2b3a	XP_005166875.1	ATPase-IIB_Ca	23..1082	CDD:273668	248/1249 (20%)
		Cation_ATPase_N	57..116	CDD:279080	14/36 (39%)
		E1-E2_ATPase	164..484	CDD:278548	66/352 (19%)
		Cation_ATPase	545..634	CDD:289987	30/110 (27%)
		HAD	627..825	CDD:289480	61/337 (18%)
		Cation_ATPase_C	899..1077	CDD:279079	40/199 (20%)
		ATP_Ca_trans_C	1122..1198	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930