Protein Alignment anne and atp2b3a

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_005166875.1
• Gene: atp2b3a / 436745
• ZFINID: ZDB-GENE-040718-174
• Length: 1299
• Species: Danio rerio
• Alignment Length: 1250
• Identity: 249/1250 - (19%)
• Similarity: 396/1250 - (31%)
• Gaps: 477/1250 - (38%)

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY------YACV----- 381
            ||.|||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|.      .|||
Zfish    81 RRKVFGMN--FIPPKQPKTFLELVWEALQDITLIILEIAAIISLGLSFYQPPGGDSEACVEVSEG 143

  Fly   382 ----------------ILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVVD 418
                            |||..:..:.|:.            ||::..|:.....|   .|:.|:
Zfish   144 AEDEGEADANWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQRFAVV---RNSTVI- 204

  Fly   419 HKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDM 482
                  ::|...:|.|||.:: ..|..|..|.:||.||.: :|||.|||||..|.|:
Zfish   205 ------QIPVAEMVVGDIAQV-KYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKS-------- 254

  Fly   483 IFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNIT-------AKGELIRSILYPPPVDYK 540
             .||..    .|..||.|::    ||.|:|...:...:.|       ..||:...     ..|.|
Zfish   255 -IDKDP----MLLSGTHVME----GSGKMLVTAVGVNSQTGIIFTLLGAGEMEEE-----KKDCK 305

  Fly   541 FEQDSYKFIQF------------------------------------------------------ 551
            .|.:|....||
Zfish   306 KEVNSNSSTQFPSVEAKEHNIINGKQDGTLENNQNKAKKQDEAVAMEMQPLKSAEGGEVEEKEKK 370

  Fly   552 ------------------LAI-IACVGFIYTLVTKI------------------LRGTDP----- 574
                              ||: |...|.:.:.:|.|                  |....|
Zfish   371 KASVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILMLYFVIKTFIVHKQPWLTECTPIYVQY 435

  Fly   575 -VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTL 638
             ||..:..:.::.:.||..||.|:|:...|:.|::...........:....|:....|.||||||
Zfish   436 FVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 500

  Fly   639 TEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTG 703
            |.:.:.   ||.....:|....:.:.|::                        :|..|::..|.
Zfish   501 TTNRMT---VVQIYIGDQLFRDIPTPDQI------------------------NPRTLELISSA- 537

  Fly   704 WELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKN 768
                .:.|...|.|   :.|.   ...|||    ..:.|:|.|          .|.:|:....|.
Zfish   538 ----IAVNCAYTSK---IMPA---DKEGGL----PKQVGNKTE----------CALLGLVLDLKQ 578

  Fly   769 FDHGIVRE----------FPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLC---------- 813
             |:..|||          :.|.|..:.||.|.: :.|..|.:|.||:.|:|.|.|
Zfish   579 -DYQAVREQIPEELLYKVYTFNSVRKSMSTVIQ-MPDGSFRLYSKGASEILLKKCSFILSRDGEA 641

  Fly   814 ---KPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKM-----NYTKVQRLSREEVENNMEFLGF 870
               :.:...:...:.:...|..|.|.|.||::.|....     |.|        ::.:|:..:..
Zfish   642 RAFRARDKDEMVKKVIEPMACDGLRTICIAYRELPADPLPDWDNET--------DIVSNLTCITV 698

  Fly   871 VILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSAN 935
            |.:|:.::|:....|.....|.|...|:|||||.||.::|..|||:.|            ||
Zfish   699 VGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIHP------------GD--- 748

  Fly   936 IQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHME 1000
                                                               :|....||
Zfish   749 ---------------------------------------------------DFLCMEGK------ 756

  Fly  1001 STNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQ 1065
                                                |....|::...|.  .||.|    .|.|.
Zfish   757 ------------------------------------DFNRRIRNEKGEI--EQERI----DKIWP 779

  Fly  1066 IVKDYFPEEMEILLTRGSIYARMSPDQKQAL--------VIELQNLDYCVAMCGDGANDCGALKV 1122
            .::               :.||.||..|..|        |:|.:.:   ||:.|||.||..|||.
Zfish   780 KLR---------------VLARSSPTDKHTLVKGIIDSTVVEQRQV---VAVTGDGTNDGPALKK 826

  Fly  1123 AHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMI 1184
            |..|.::......:   ||.....:...|:::|.:..||....:   |.|::.....|..::|::
Zfish   827 ADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTVNVVAVIV 888

  Fly  1185 LY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISSTPLASLL 1241
            .:     :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   :.|||.|.:.::|
Zfish   889 AFTGACITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTEALLLRKPYGRNNPLISRTMMKNIL 952

  Fly  1242 LHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRK 1306
            .|    ..:|:.....|                  .|....:|.|.|          .:.||...
Zfish   953 GH----AVYQLVIIFTL------------------LFAGERIFDIDS----------GRDAPLHS 985

  Fly  1307 PLWSNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFRYVMLAYG 1358
            |...::.:    |.|..:::.|.             ::...:....|..||..|...:.|::.:|
Zfish   986 PPSEHYTI----IFNTFVLMQLFNEINARKIHGERNVFDGIFSNPIFCSIVLGTFAIQIVIVQFG 1046

  Fly  1359 AASFICH-IFVESFL 1372
            ...|.|. :.||.:|
Zfish  1047 GKPFSCSPLNVEQWL 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	229/1143 (20%)
atp2b3a	XP_005166875.1	ATPase-IIB_Ca	23..1082	CDD:273668	248/1249 (20%)
		ATP_Ca_trans_C	1122..1197	CDD:463575