DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp13a2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_006239308.1	Gene:	Atp13a2 / 362645	RGDID:	1307977	Length:	1173	Species:	Rattus norvegicus

Alignment Length:	1325	Identity:	456/1325 - (34%)
Similarity:	676/1325 - (51%)	Gaps:	200/1325 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 SKDSERLVDDSKPCIGLL------NP--DQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLH 193
            |.||..|:..:.|..|.|      :|  .....:::.||..|..|.....|.:::..|:..|:..
  Rat     2 SADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFR 66

  Fly   194 WWRHLYLYATCSQCSLEEAEQVLV-TEDYQGKHKMYHVKQIQVLTSSNLKTLLE-------KEQQ 250
            |.....:......|||..||.::: ..|.:|..:.....|:|  |.:.:...||       ::.:
  Rat    67 WKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQLFTVQVQ--TEAVVDGSLELPSQAKAEDGR 129

  Fly   251 SIERTHIECDHV-ENVLQLSVHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPC 314
            |:....:..:.: ::..||.....:.|.     :|.:..:...|.|......|.:::.||....|
  Rat   130 SLAAVGVAPESMWQDTTQLHRQKEAKQV-----LRYYILQGQRYVWMETQQAFCQVSLLDHGRAC 189

  Fly   315 SYYH-QQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYY 378
            ...| ...||.:.:|..|:.::|.|.|.:|::.:..||..|.|||:|.||.||:.||....||:|
  Rat   190 DDIHCSSSGLSLQDQAVRKTIYGPNVIGIPVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWY 254

  Fly   379 ACVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSG 443
            |..|.|:|...|.:|:.:|:|....|:..|..:....|....|..:.:.:..:||||.:.:|..|
  Rat   255 AVCIFLISAISICLSLYKTRKQSMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEG 319

  Fly   444 CTLHCDAILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTR-YIG 507
            ..:.|||.|::|.|:::||.|||||:||.||.||........:| |.||||||||.|:|.| |:|
  Rat   320 GMMPCDAALVAGECVVNESSLTGESIPVLKTALPEGPQPYCPET-HRRHTLFCGTLVLQARAYLG 383

  Fly   508 SKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGT 572
             .:|||.|..||..||||.|:.|||:|.|:.:||.:.|.||:..|:::|.:|.||:::. :.|..
  Rat   384 -PRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIII-LYRNR 446

  Fly   573 DPVK-IAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTG 636
            .||| |.:.:|||:|:||||||||||||...|||.||:|..||||.|..||:.|.:...||||||
  Rat   447 VPVKEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTG 511

  Fly   637 TLTEDGLDMWGVVPKSSTNQFQIPL-KSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFE 700
            ||||||||:.||||..  .|..:|| .....||....|..:||||:::.|:..::|||:||||.|
  Rat   512 TLTEDGLDIMGVVPLK--GQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGDPMDLKMVE 574

  Fly   701 STGWELED---SNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGI 762
            ||||.||:   :.:.|:|:...::.|    .|||     .:.:..|...:
  Rat   575 STGWVLEEGSAAGSAPETQVLVVMRP----PPRG-----PQQQEESPEPV--------------- 615

  Fly   763 SPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLS 827
                     .::|.|||:||||||.||...........|.|||||::..||.|:::|.::.|.|.
  Rat   616 ---------SVLRRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQ 671

  Fly   828 EFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAK 892
            .:...|||::|:|.|.|....:....|:|:|:.||..:..||.:::.|.|||.||.||..|....
  Rat   672 SYTAAGYRVVALAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTG 736

  Fly   893 IRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLH 957
            |||:|:||||:.||::||:.||:|...:.:..:||            |..|..
  Rat   737 IRTVMVTGDNLQTAVTVAKACGMVGTQEHLAIIHA------------THPEQG------------ 777

  Fly   958 YTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSD 1022
                                    .|...||                             |||..
  Rat   778 ------------------------QPAALEF-----------------------------LPTEP 789

  Fly  1023 SLASVKTIDTWTHNDAELGIKHT-----PDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRG 1082
            |.|.         |.|:..::.|     |:...|.    .|:.|.|:.:::.:||:.:..:|.:.
  Rat   790 SAAM---------NGAKDPVQATDYPVEPESQSRH----LALSGSTFAVLQKHFPKLLPKVLVQA 841

  Fly  1083 SIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTI 1147
            :::|||:|:||..||.|||.|.|||.|||||||||||||.|..|||||:.|||:.|||||...:|
  Rat   842 TVFARMAPEQKTQLVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASI 906

  Fly  1148 SAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFF 1212
            ..|..||:|||.:|.|||.:|||||.|||.|||||:|||:|::||.|.|:|.:||.:.:..|...
  Rat   907 ECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLM 971

  Fly  1213 GKTESFDG---MLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFE---PAD 1271
            .:|    |   .||...|..:|:|...|.||||.:.:|...|:..:..:..||||....   ||
  Rat   972 SRT----GPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPA- 1031

  Fly  1272 EDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWV 1336
            .|:|..:||..:|.:|.|||:|||...|||||:|:||::|.|..:|..:...::|.|:|.|.
  Rat  1032 PDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNVPFLVALALLGSVLVGLILVPG--- 1093

  Fly  1337 ASFFQLIVPP-------TMRFRYVMLAYGAASFICHIFVESFLVEYL--VFKKYQVKREKNWVTS 1392
                 |:..|       ...|:.::|...|.:|:....:||.|.:.|  ..:..:.||     .|
  Rat  1094 -----LLQGPLGLRNIADSSFKLLLLGLVAFNFVGAFMLESVLDQCLPACLQWLRPKR-----AS 1148

  Fly  1393 KQKYMRLEHDISNIKNWP--PITEV 1415
            |:::.:|:.:::. :.||  |:..|
  Rat  1149 KKQFKQLQRELAE-RPWPTLPVGSV 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	25/141 (18%)
		P-ATPase-V	173..1355	CDD:273738	429/1215 (35%)
		E1-E2_ATPase	381..621	CDD:278548	109/241 (45%)
		Cation_ATPase	<758..813	CDD:289987	18/54 (33%)
		HAD_like	<1087..1137	CDD:304363	36/49 (73%)
Atp13a2	XP_006239308.1	P-ATPase-V	39..1116	CDD:273738	433/1224 (35%)
		P5-ATPase	39..>110	CDD:289194	17/72 (24%)
		E1-E2_ATPase	258..493	CDD:278548	108/237 (46%)
		Cation_ATPase	<621..658	CDD:289987	18/36 (50%)
		COG4087	<843..>892	CDD:226572	34/48 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334757
Domainoid	1	1.000	76	1.000	Domainoid score	I8801
eggNOG	1	0.900	-	-		E2759_KOG0208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm44510
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	1	1.100	-	-	O	PTHR45630
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.720