DRSC/TRiP Functional Genomics Resources

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Protein Alignment anne and ATP13A5

DIOPT Version :9

Sequence 1:NP_001096849.1 Gene:anne / 317815 FlyBaseID:FBgn0052000 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_940907.2 Gene:ATP13A5 / 344905 HGNCID:31789 Length:1218 Species:Homo sapiens


Alignment Length:1327 Identity:475/1327 - (35%)
Similarity:696/1327 - (52%) Gaps:232/1327 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHW---WRHLYLYATCSQCSLEEAEQ 214
            |||..:||:::|.|||...:|..||.....||.|.|.||.:|   ||   ::|.|..|.|:||:.
Human    12 LLNQGEEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWR---VWANCIPCPLQEADT 73

  Fly   215 VLV--TEDYQGKHKMYHVKQIQVLTSSNLKTLLEK--EQQSIERTHIECDHVENVLQLSVHFTSA 275
            ||:  |:::|    .|..|::..|..|.||..:.|  |:..:...|            || ...|
Human    74 VLLRTTDEFQ----RYMRKKVFCLYLSTLKFPVSKKWEESLVADRH------------SV-INQA 121

  Fly   276 QFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPV--HEQISRRIVFGDN 338
            ..|....:|....:::.|.||:...|||::..|:.:..||..||..||.:  .||..||:|.|.|
Human   122 LIKPELKLRCMEVQKIRYVWNDLEKRFQKVGLLEDSNSCSDIHQTFGLGLTSEEQEVRRLVCGPN 186

  Fly   339 EITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDV 403
            .|.|.::....||..:|||||||||.|::.||.:..|..|:..|::::|..|.:||...::....
Human   187 AIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVK 251

  Fly   404 LQKTVYNTGNAWV---VDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLT 465
            |...|.:.....|   |..||| :||.:|.:|||||:.:|.. .:|.|||:||.|:|:::|.|||
Human   252 LHNLVEDHNKVQVTIIVKDKGL-EELESRLLVPGDILILPGK-FSLPCDAVLIDGSCVVNEGMLT 314

  Fly   466 GESVPVTKTPLPSKRDMI----FDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGE 526
            |||:||||||||...:.:    ....::.:|.|||||:|||.:..|...|.|.|:.||..||||:
Human   315 GESIPVTKTPLPQMENTMPWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGD 379

  Fly   527 LIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPP 591
            |:||||||.|:::|...|::|||.|||.:..:||.|.|...:..|..|......:|.|:|:.|||
Human   380 LVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPP 444

  Fly   592 ALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQ 656
            .||||:|:|..|||||||..:||||||:.||:.|.||..||||||||||||||:||.|| ::.|.
Human   445 VLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVP-TADNC 508

  Fly   657 FQ--IPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYG 719
            ||  ....|...:|:......|.:|||:.:|||.:.||||||||||.|.|::||.  |.|:.|:|
Human   509 FQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDC--IVDSCKFG 571

  Fly   720 ILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQ 784
            .....|::             .|.|   ..:|.|:.::.               :.:|||:|:||
Human   572 TSVSNIIK-------------PGPK---ASKSPVEAIIT---------------LCQFPFSSSLQ 605

  Fly   785 RMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKM- 848
            ||||:.:...:..|:||.||:|||:.:.|:.:::|.|:.|:|..:..:|:|:||:|.|.|  || 
Human   606 RMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAHKTL--KMG 668

  Fly   849 NYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDC 913
            |.::|:.|:||:||:.:.|||.:|:|||||.:|..|:..|:.|:|||:||||||:.|||:||::.
Human   669 NLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNS 733

  Fly   914 GIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNS 978
            .::.|...||.|.||                                                  
Human   734 EMIPPGSQVIIVEAD-------------------------------------------------- 748

  Fly   979 NLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTW---THNDAEL 1040
               :||  ||..                                  |||    ||   .:.:...
Human   749 ---EPE--EFVP----------------------------------ASV----TWQLVENQETGP 770

  Fly  1041 GIK----HTPDESWRRQE---CI-FAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALV 1097
            |.|    ||.:.|..|.|   |. |||.||::|::..:|...:..:|..|:::|||||.||.:|:
Human   771 GKKEIYMHTGNSSTPRGEGGSCYHFAMSGKSYQVIFQHFNSLLPKILVNGTVFARMSPGQKSSLI 835

  Fly  1098 IELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALV 1162
            .|.|.|:|.|.|||||||||||||.|||||||||.|||:||||||:...|..|..:|:|||||||
Human   836 EEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLIREGRAALV 900

  Fly  1163 TSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVP 1227
            :|||:|||:..|.::||||.::||.......:.|||..|:.:..:.......|.::. .|....|
Human   901 SSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLTMSSTHAYP-KLAPYRP 964

  Fly  1228 LSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLG---------------- 1276
            ...|:|...|.|:.|:.......|::.::::.||||:.......|..|.                
Human   965 AGQLLSPPLLLSIFLNSCFSCIVQISAFLYVKQQPWYCEVYQYSECFLANQSNFSTNVSLERNWT 1029

  Fly  1277 -----------CFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVL 1330
                       .||..|::.|::..||.:||:||||.|:|||:::|:......:..|.:.::::.
Human  1030 GNATLIPGSILSFETTTLWPITTINYITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGLTIFILF 1094

  Fly  1331 YPSDWVASFFQLI------VPPTMRFRYVMLAYGAASFICHIFVESFLVE----YLVFKKYQVKR 1385
                   |.||:|      :|....:|.::|......|....|||..:::    :|:     :||
Human  1095 -------SDFQVIYRGMELIPTITSWRVLILVVALTQFCVAFFVEDSILQNHELWLL-----IKR 1147

  Fly  1386 EKNWVTSKQKYMRLEHDISNIKNWPPI 1412
            |..:. ||.:|...:..::....||||
Human  1148 EFGFY-SKSQYRTWQKKLAEDSTWPPI 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
anneNP_001096849.1 P5-ATPase 158..291 CDD:289194 42/139 (30%)
P-ATPase-V 173..1355 CDD:273738 450/1244 (36%)
E1-E2_ATPase 381..621 CDD:278548 110/246 (45%)
Cation_ATPase <758..813 CDD:289987 18/54 (33%)
HAD_like <1087..1137 CDD:304363 37/49 (76%)
ATP13A5NP_940907.2 P5-ATPase 17..137 CDD:289194 42/139 (30%)
P-ATPase-V 18..1119 CDD:273738 456/1259 (36%)
Cation_ATPase_N <170..239 CDD:279080 27/68 (40%)
E1-E2_ATPase 228..471 CDD:278548 108/244 (44%)
Cation_ATPase <595..636 CDD:289987 19/40 (48%)
COG4087 <822..>871 CDD:226572 35/48 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141089
Domainoid 1 1.000 120 1.000 Domainoid score I5750
eggNOG 1 0.900 - - E2759_KOG0208
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54176
OrthoDB 1 1.010 - - D172453at2759
OrthoFinder 1 1.000 - - FOG0000757
OrthoInspector 1 1.000 - - otm40375
orthoMCL 1 0.900 - - OOG6_100379
Panther 1 1.100 - - O PTHR45630
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X554
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.720

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