Protein Alignment anne and atp13a1

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001001403.2
• Gene: atp13a1 / 334466
• ZFINID: ZDB-GENE-040426-2804
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1359
• Identity: 330/1359 - (24%)
• Similarity: 525/1359 - (38%)
• Gaps: 397/1359 - (29%)

  Fly   175 GFCWACIFLTGGLLRLVL------------HWWRHLYLYATCSQCSLEEAEQVLVTEDYQGKHKM 227
            |...|..::..|||.|..            :|..|.:...|||    :|::....|
Zfish    64 GVYGAAEYVEAGLLALAALGIAHVLTVLSGYWSVHAHCLLTCS----KESDPAKAT--------- 115

  Fly   228 YHVKQIQVLT--SSNLKTLL-EKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRCK 289
             ..|.|....  |:.|..|| :|::...|                             |..|..:
Zfish   116 -FAKVIPTPNNGSAELVPLLRDKDEDGAE-----------------------------ILSFEFQ 150

  Fly   290 QLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIV---FGDNEITVPLRDFKTLL 351
            ::.|.::....:........::.|.|::...||  ..|::..|..   :|.|...:.:.||..|.
Zfish   151 KICYVYDGEEKKQFLPVAFPISFPMSHFQNWRG--YQEEVQLRAAEKRYGTNRAEMVVPDFLELF 213

  Fly   352 FLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQK--------TV 408
            ......||:|||:|.|.||...:|:||:...|.|.|......|.|..:|...:::        .|
Zfish   214 KERATAPFFVFQVFCVGLWCLDEYWYYSVFTLFMLVAFEASLVQQQMRNMSEIRRMGNKPYMIQV 278

  Fly   409 YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSS--GCTLHCDAILISGNCILDESMLTGESVPV 471
            |. ...|        :.:.:..:|||||:.:..|  ...:.||.:|:.|.||:||:||||||||.
Zfish   279 YR-NRKW--------RPISSDELVPGDIVSVGRSPQDNLVPCDVLLLRGRCIVDEAMLTGESVPQ 334

  Fly   472 TKTPL----PSKRDMIFD-KTEHARHTLFCGTKVIQ-----TRYIGSKKV----LAFVINTGNIT 522
            .|.|:    |::   |.| :|:...|.:..||||:|     ....|.|.|    :|:|:.||..|
Zfish   335 MKEPIEDLDPNR---ILDLQTDSRLHIISGGTKVVQHSPPLRASAGLKPVDNGCVAYVLRTGFYT 396

  Fly   523 AKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGT-DP----VKIAVESL 582
            ::|:|:|:||:..........:::.||.||.:.|....:|..|    .|| ||    .|:.:|..
Zfish   397 SQGKLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAVYVWV----EGTKDPSRNKYKLFLECT 457

  Fly   583 DLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWG 647
            .::|.||||.||..:::....:...|....:||..|..|..||.:..||||||||||.|.|.:.|
Zfish   458 LILTSVVPPELPIELSLAVNTSLIALAKLYVFCTEPFRIPFAGKVEICCFDKTGTLTSDSLVVRG 522

  Fly   648 VVPKSSTNQFQIPLKSVDRLPFD-HFLFGMVTCHS-ITILNGRMMGDPLDLKMFESTGWELEDSN 710
            |.......|    :..|..:|.| |.:  :.|||| :|:.:|:::||||:..|..:..|.|....
Zfish   523 VAGLREGKQ----VMPVSEIPVDTHRV--VATCHSLVTLDDGQLVGDPLEKAMLTAADWTLTKDE 581

  Fly   711 NIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVR 775
            .:         :...::.|  ||.                                      |.:
Zfish   582 KV---------FARSIKTP--GLK--------------------------------------IHQ 597

  Fly   776 EFPFTSALQRMSVVTR---------CLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAK 831
            .|.|||||:||||:..         |....|     ||:||.|:.:.  ...|.:|.:...|.::
Zfish   598 RFHFTSALKRMSVLASYERMGSTELCYISTV-----KGAPETLRNMF--SECPASYDEVHREMSR 655

  Fly   832 KGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTI 896
            :|.|::|:.:|.:.| :::.:|:.:|||::|.::.|.||:::...||.|:..||..:..|....:
Zfish   656 EGARVLALGYKEMGH-LSHQQVREVSREQLECDLRFAGFMVVSCPLKSDSKAVIREIQEASHHVV 719

  Fly   897 MITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLD 961
            ||||||.|||..|||:                                           ||:
Zfish   720 MITGDNPLTACHVARE-------------------------------------------LHF--- 738

  Fly   962 LGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLAS 1026
                                                 ::..::|:.:.:||.||.
Zfish   739 -------------------------------------IQKEHTLILQQSSSQAEW---------- 756

  Fly  1027 VKTIDTWTHNDAELGIKHTPDE-SWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSP 1090
                 .|...|..:.:...|.. |...|.....:.|:....:| :.|:.:..||....::||:||
Zfish   757 -----QWVSIDGSVSLPLPPSSVSELIQRYDLCVTGEGLARLK-FDPQLLSALLPHVRVFARVSP 815

  Fly  1091 DQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISL---------------SETE------- 1133
            .||:.::..|:.|.:...|||||.||.||||.||.|::|               .|.|
Zfish   816 KQKEFVITSLKGLGFVTLMCGDGTNDVGALKHAHIGVALLANAPERMPEKKKRNKEKEYSSGESR 880

  Fly  1134 -------------------------------------------------------ASIASPFTSR 1143
                                                                   ||||:||||:
Zfish   881 PGPPVPTSGGKLSSRAARQRLMAQREEQLAAQKERISQVLRELEEDQIQVVKLGDASIAAPFTSK 945

  Fly  1144 NPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIF 1208
            ..:|..:..|||:||..|||:..:||.:|..:|:...|..:||......:|.|.....|.|...|
Zfish   946 LSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCF 1010

  Fly  1209 AFFFGKTESFDGMLVEQVPLSSLISSTPLASLLLHLTVVT-----AFQVTCWVHLH-----QQP- 1262
            .|           :....||.||....||.::....||:|     |......|:|:     :.|
Zfish  1011 LF-----------ISRSKPLKSLSKERPLPNIFNLYTVLTVLLQFAVHFCSLVYLYKGAQTRSPP 1064

  Fly  1263 -------WFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIV 1320
                   .:|.|||:       ..|.|::.:|....:....:..||.|:.:.|..|.||..:..:
Zfish  1065 RSEQFVDLYKEFEPS-------LINSTVYIMSMAMQMATFAINYKGHPFMESLTENRPLLWSIAI 1122

  Fly  1321 NLCIIVYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFK 1379
            :...||.|:...|......|.|:..|| .|:.::.......|:..:.|:..| ::|:.|
Zfish  1123 SGLAIVGLLTGSSPEFNEQFALVDIPT-EFKLIIAQVLVVDFVAALLVDRVL-QFLLGK 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	24/135 (18%)
		P-type_ATPase_cation	326..1281	CDD:319842	278/1093 (25%)
atp13a1	NP_001001403.2	P-type_ATPase_cation	189..1116	CDD:319843	285/1122 (25%)