Protein Alignment anne and Atp2b1

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_038934528.1
• Gene: Atp2b1 / 29598
• RGDID: 621303
• Length: 1258
• Species: Rattus norvegicus
• Alignment Length: 1221
• Identity: 242/1221 - (19%)
• Similarity: 395/1221 - (32%)
• Gaps: 430/1221 - (35%)

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYY---------------- 376
            |..|||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|
  Rat    81 REAVFGKN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVG 143

  Fly   377 ----------YYACVILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVVDH 419
                      .....|||..|..:.|:.            ||::..|:  ||        :.|..
  Rat   144 EEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQE--QK--------FTVIR 198

  Fly   420 KGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDMI 483
            .|...::|...|..|||.:: ..|..|..|.|||.||.: :|||.|||||..|.|:
  Rat   199 GGQVIQIPVADITVGDIAQV-KYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS--------- 253

  Fly   484 FDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNIT--------AKGELIR----------- 529
            .||..    .|..||.|::    ||.:::...:...:.|        |.||...
  Rat   254 LDKDP----LLLSGTHVME----GSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKN 310

  Fly   530 ------------------SILYPPPVDYK-----FEQDSYKF-------------IQFLAI-IAC 557
                              :.:...|:..:     .|:|..|.             :..||: |..
  Rat   311 KKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGK 375

  Fly   558 VGFIYTLVTKI------------------LRGTDP------VKIAVESLDLITIVVPPALPAAMT 598
            .|.:.:.:|.|                  |....|      ||..:..:.::.:.||..||.|:|
  Rat   376 AGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVT 440

  Fly   599 VGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKS 663
            :...|:.|::...........:....|:....|.|||||||         :.:.:..|..|..|.
  Rat   441 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT---------MNRMTVVQAYINEKH 496

  Fly   664 VDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQ 728
            ..::|....:                   |.::..:..||    .|.|...|.|  ||.|    :
  Rat   497 YKKVPEPEAI-------------------PPNILSYLVTG----ISVNCAYTSK--ILPP----E 532

  Fly   729 PRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNF--------DHGIVREFPFTSALQR 785
            ..|||    ....|:|.|......:.||         ::::        :..:.:.:.|.|..:.
  Rat   533 KEGGL----PRHVGNKTECALLGFLLDL---------KRDYQDVRNEIPEEALYKVYTFNSVRKS 584

  Fly   786 MSVVTRCLSDQVFNVYCKGSPEMLKKLC-------------KPQSLPDNYSQQLSEFAKKGYRII 837
            ||.|.: .||..|.::.||:.|::.|.|             :|:...|.....:...|.:|.|.|
  Rat   585 MSTVLK-NSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTI 648

  Fly   838 AIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDN 902
            .:||:  .......:.:..:..:|...:..:..|.:|:.::|:..:.|.....|.|...|:||||
  Rat   649 CLAFR--DFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGITVRMVTGDN 711

  Fly   903 ILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTS 967
            |.||.::|..|||:.|.:
  Rat   712 INTARAIATKCGILHPGE----------------------------------------------- 729

  Fly   968 RAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDT 1032
                               :|....||
  Rat   730 -------------------DFLCLEGK-------------------------------------- 737

  Fly  1033 WTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALV 1097
                |....|::...|.  .||.|    .|.|..::               :.||.||..|..||
  Rat   738 ----DFNRRIRNEKGEI--EQERI----DKIWPKLR---------------VLARSSPTDKHTLV 777

  Fly  1098 -----IELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVI 1154
                 ..:......||:.|||.||..|||.|..|.::......:   ||.....:...::::|.:
  Rat   778 KGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAV 842

  Fly  1155 KEGRAALVTSFGIFKYMAAYSLVQFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGK 1214
            ..||....:   |.|::.....|..::|::.:     :.||.|...|.|:|:| ::...|.....
  Rat   843 MWGRNVYDS---ISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTLASLALA 903

  Fly  1215 TESFDGMLVEQVPL---SSLISSTPLASLLLH--LTVVTAFQVTCWVHLHQQPWFKAFEPADED- 1273
            ||.....|:.:.|.   ..|||.|.:.::|.|  ..:|..|.:.          |...:..|.|
  Rat   904 TEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLL----------FAGEKFFDIDS 958

  Fly  1274 ------HLGCFENYTMFCISSFQYIILAFVFSKGAPYRK---------PLWSNWPLCL----AFI 1319
                  |....|:||:.    |...:|..:|:: ...||         .:::|...|.    .|:
  Rat   959 GRNAPLHAPPSEHYTIV----FNTFVLMQLFNE-INARKIHGERNVFEGIFNNAIFCTIVLGTFV 1018

  Fly  1320 VNLCIIVY-------LVLYPSDWVASFF---------QLI-VPPTMRFRYV 1353
            |.:.|:.:       ..|....|:.|.|         ||| ..||.|.:::
  Rat  1019 VQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFL 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	220/1117 (20%)
Atp2b1	XP_038934528.1	ATPase-IIB_Ca	15..1064	CDD:273668	240/1214 (20%)
		ATP_Ca_trans_C	1103..1187	CDD:463575