DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001257959.1	Gene:	Atp1a4 / 29132	RGDID:	61952	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	1041	Identity:	222/1041 - (21%)
Similarity:	378/1041 - (36%)	Gaps:	315/1041 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 NNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEIT---------------VPLRD 346
            :||||..::.           .:::.|   |::.:.:|..|:::|               :.:.|
  Rat    22 SNTNRQPKVK-----------RRKKDL---EELKKEVVMDDHKLTLDELSAKYSVDLTKGLSVTD 72

  Fly   347 FKTLLFL---EVLNP-----------FYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQT 397
            .:.:|.|   .||.|           ..:|..||::||        ...:|....:||.||..|.
  Rat    73 AQEILTLNGPNVLTPPPTTPEWIKFCKQLFGGFSLLLW--------TGSLLCFLAYGIHVSYYQE 129

  Fly   398 KKNQD------VLQKTVYNTG-----------------------NAWVVDHKGLSKELPTRAIVP 433
            ..|:|      ||...|..||                       .|.|: ..|...::..|.:|.
  Rat   130 NANKDNLYLGIVLSAVVIITGCFSYYQEAKSSKIMESFKTMVPQQALVI-RDGEKMQINVRDVVL 193

  Fly   434 GDIIEIPSSGCTLHCD-AILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCG 497
            ||::|: ..|..:..| .::.:..|.:|.|.|||||.|.::.|     |...:.....|:.:|..
  Rat   194 GDLVEV-KGGDQVPADIRVIAAQGCKVDNSSLTGESEPQSRCP-----DCTHENPLETRNIIFFS 252

  Fly   498 TKVIQTRYIGSKKVLAFVINTGNITAKGELIRSI-----LYPPPVDYKFEQDSYKFIQFLAIIAC 557
            |..::    |:.:  ..||.||:.|..|. |.|:     :...|:..:.|.    ||..:..:|.
  Rat   253 TNCVE----GTAR--GVVIATGDHTVMGR-IASLTSGLTMGKTPIATEIEH----FIHIITAVAV 306

  Fly   558 -VGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSI 621
             :|..:..::.|| |...:...:..:.:|...||..|.|.:||......||:........:..::
  Rat   307 FLGVTFFFLSLIL-GYTWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAV 370

  Fly   622 NVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILN 686
            ...||.:..|.|||||||::.:                   :|..|.||..::
  Rat   371 ETLGSTSTICSDKTGTLTQNRM-------------------TVAHLWFDKTVY------------ 404

  Fly   687 GRMMGDPLDLKMFESTGWELEDSNNIPDTEKY-----GILYPTILRQPRGGLSGMAETESGSKNE 746
                  ..|....::||.....|:   ||..|     |:......:..:..|.....|.:|..:|
  Rat   405 ------EADTSEEQTTGKTFPKSS---DTWFYLARIAGLCNRADFKPHQESLPITKRTTTGDASE 460

  Fly   747 IKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQ-RMSVVTRCLSD--QVFNVYCKGSPEM 808
            ......::...:.|. ...|||   ..|.|.||.|..: :||:  ..|.|  :...:..||:||.
  Rat   461 SALLKFIEQSYSPVS-EMRQKN---PKVAEIPFNSTNKYQMSI--HLLEDNSEAHVLLMKGAPER 519

  Fly   809 LKKLCK-----------PQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVE 862
            :...|.           .:.:..::.....|....|.|::...|  |:...|::|..:.:.||:.
  Rat   520 ILDFCSSFLLNGQEYPMDEEMKTDFQNAYIELGGLGERVLGFCF--LNLPSNFSKGFQFNTEELN 582

  Fly   863 NNMEFLGFVILENRLKPDTTKVINALN---AAKIRTIMITGDNILTAISVARDCGIVSPSQSVIT 924
            ..||.|.|..|.:.:.|..|.|.:|::   :|.|:.||:|||:.:||.::|:..||:|.:...
  Rat   583 FPMENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEANET-- 645

  Fly   925 VHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFT 989
              |:.|....||
  Rat   646 --AEDIAARLNI----------------------------------------------------- 655

  Fly   990 AQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQE 1054
                       |.:.:.|:|..:....|       :.:|.:|:
  Rat   656 -----------SISQVSNKSIKAIVVHG-------SELKDMDS---------------------- 680

  Fly  1055 CIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGA 1119
                  |:...|:|.|    .||      ::||.||.||..:|...|.|...||:.|||.||..|
  Rat   681 ------GQLDNILKSY----KEI------VFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPA 729

  Fly  1120 LKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSL---VQ 1178
            ||.|..||::..|.:.:   |:.....:...::::..::|||..    |...|...||:|   :.
  Rat   730 LKKADIGIAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSNIP 790

  Fly  1179 FISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLLH 1243
            .|:..:|:.:.|       :.:.||.|:|.....|         .:.||..||...||.:.::..
  Rat   791 EITPFLLFIVLS-------IPLPLGTITILCIDLG---------TDMVPAISLAYETPESDIMKR 839

  Fly  1244 L 1244
            |
  Rat   840 L 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	222/1041 (21%)
		E1-E2_ATPase	381..621	CDD:278548	64/275 (23%)
		Cation_ATPase	<758..813	CDD:289987	17/57 (30%)
		HAD_like	<1087..1137	CDD:304363	22/52 (42%)
Atp1a4	NP_001257959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		4/24 (17%)
		ATPase-IIC_X-K	32..1028	CDD:273445	218/1020 (21%)
		Cation_ATPase_N	46..119	CDD:214842	14/80 (18%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	87..89		1/1 (100%)
		E1-E2_ATPase	140..371	CDD:278548	56/249 (22%)
		Cation_ATPase	434..526	CDD:289987	22/97 (23%)
		COG4087	608..757	CDD:226572	53/261 (20%)
		Cation_ATPase_C	804..1013	CDD:279079	12/46 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840