DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment anne and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_038762.1	Gene:	Atp1a4 / 27222	MGIID:	1351335	Length:	1032	Species:	Mus musculus

Alignment Length:	1024	Identity:	221/1024 - (21%)
Similarity:	366/1024 - (35%)	Gaps:	327/1024 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 EQISRRIVFGDNEIT---------------VPLRDFKTLLFL---EVLNP-----------FYVF 362
            |::.:.:|..|:::|               :.:.:.:.:||.   .||.|           ..:|
Mouse    42 EELKKEVVMDDHKLTLDELSAKYSVDLTKGLSILEAQDILFQNGPNVLTPPPTTPEWVKFCRQLF 106

  Fly   363 QLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQD------VLQKTVYNTG--------- 412
            ..||::||..      ||:..|  .:||.|:..:...|:|      ||...|..||
Mouse   107 GGFSLLLWTG------ACLCFL--AYGIHVNYYKENANKDNLYLGIVLSAVVIITGCFSYYQEAK 163

  Fly   413 --------------NAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISG-NCILDES 462
                          .|.|: ..|...::..|.:|.||::|: ..|..:..|..:||. .|.:|.|
Mouse   164 SSKIMESFKNMVPQQALVI-RDGEKMQINVRDVVLGDLVEV-KGGDQIPADIRVISAQGCKVDNS 226

  Fly   463 MLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGEL 527
            .|||||.|.::.|     |...:.....|:.:|..|..::    |:.:  ..||.||:.|..|.
Mouse   227 SLTGESEPQSRCP-----DCTHENPLETRNIIFFSTNCVE----GTAR--GIVIATGDYTVMGR- 279

  Fly   528 IRSI-----LYPPPVDYKFEQDSYKFIQFLAIIAC---VGFIYTLVTKILRGTDPVKIAVESLDL 584
            |.|:     :...|:..:.|.    ||..:..:|.   |.|.:   ..|:.|...:...:..:.:
Mouse   280 IASLTSGLQMGKTPIATEIEH----FIHLITAVAVFLGVSFFW---LSIILGYTWLDAVIFLIGI 337

  Fly   585 ITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGL---DMW 646
            |...||..|.|.:||......||:........:..::...||.:..|.|||||||::.:   .:|
Mouse   338 IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLW 402

  Fly   647 --GVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVT--CH---------SITILNGRMMGDPLDLKM 698
              ..|.::.|::.|...|:..:.....|....:.  |:         |:.|......||..:..:
Mouse   403 FDKTVYEADTSEEQTTGKTFPKSSDTWFYLARIAGLCNRADFKPHQESVPIAKRATTGDASESAL 467

  Fly   699 FESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGIS 763
            .:.    :|.|.| |.:|         :||               ||
Mouse   468 LKF----IEQSYN-PVSE---------MRQ---------------KN------------------ 485

  Fly   764 PSQKNFDHGIVREFPFTSALQ-RMSVVTRCLSD--QVFNVYCKGSPEMLKKLCKP-----QSLPD 820
            |.        |.|.||.|..: :||:  ..|.|  :...:..||:||.:...|..     |..|.
Mouse   486 PK--------VAEIPFNSTNKYQMSI--HLLEDNSEAHVLLMKGAPERIFDFCSSFLLNGQEYPM 540

  Fly   821 NYSQQLS------EFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKP 879
            :...::.      |....|.|::...|  |:...|::|..:.:.:|:...||.|.|..|.:.:.|
Mouse   541 DEEMKMDFQNAYIELGGLGERVLGFCF--LNLPSNFSKGFQFNTDELNFPMENLCFAGLISMIDP 603

  Fly   880 DTTKVINALN---AAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTG 941
            ..|.|.:|::   :|.|:.||:|||:.:||.::|:..||:|.....    |:.|....||..:
Mouse   604 PRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNDT----AEDIAARLNIPIS-- 662

  Fly   942 TECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLV 1006
               ..:|.|.|...:|                   .|.|.|.|:.:.
Mouse   663 ---QVNNKSVKAIVVH-------------------GSELKDMESQQL------------------ 687

  Fly  1007 NESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYF 1071
                          .|.|.|.|.|
Mouse   688 --------------DDILKSYKEI----------------------------------------- 697

  Fly  1072 PEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI 1136
                        ::||.||.||..:|...|.|...||:.|||.||..|||.|..||::..|.:.:
Mouse   698 ------------VFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIAMGITGSDV 750

  Fly  1137 ---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSL---VQFISVMILYSIDSNLTDK 1195
               |:.....:...::::..::|||..    |...|...||:|   :..|:..:|:.|.|
Mouse   751 SKQAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSNIPEITPFLLFIILS----- 806

  Fly  1196 QYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLLHL 1244
              :.:.||.|:|.....|         .:.||..||...:|.:.::..|
Mouse   807 --IPLPLGTITILCIDLG---------TDMVPAISLAYESPESDIMKRL 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	221/1024 (22%)
		E1-E2_ATPase	381..621	CDD:278548	64/277 (23%)
		Cation_ATPase	<758..813	CDD:289987	14/57 (25%)
		HAD_like	<1087..1137	CDD:304363	22/52 (42%)
Atp1a4	NP_038762.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		221/1024 (22%)
		ATPase-IIC_X-K	36..1032	CDD:273445	221/1024 (22%)
		Cation_ATPase_N	50..123	CDD:214842	15/80 (19%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	91..93		1/1 (100%)
		E1-E2_ATPase	144..375	CDD:278548	58/251 (23%)
		Cation_ATPase	438..530	CDD:289987	29/148 (20%)
		COG4087	<696..761	CDD:226572	25/117 (21%)
		Cation_ATPase_C	808..1017	CDD:279079	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840