Protein Alignment anne and Atp13a5

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_783581.2
• Gene: Atp13a5 / 268878
• MGIID: 2444068
• Length: 1216
• Species: Mus musculus
• Alignment Length: 1365
• Identity: 466/1365 - (34%)
• Similarity: 690/1365 - (50%)
• Gaps: 247/1365 - (18%)

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217
            :||..:|::::|.||....:|...|.....||.|.::|:.:|....:::.:|..|.|:||:.:|:
Mouse    12 VLNEGEENELEVFGYHTQNLRRALCLVTAILTLGAVQLMFYWRPEWWVWTSCIPCPLQEADTILL 76

  Fly   218 --TEDYQGKHKMYHVKQIQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKC 280
              |:::    :.|..|::..|..|.||..:.|..:.    .:..||...:.|       |..|..
Mouse    77 RTTDEF----RRYMRKKVFCLHLSTLKFPISKNPEE----PLVADHHSVINQ-------AVMKPE 126

  Fly   281 SSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPV--HEQISRRIVFGDNEITVP 343
            ..:|..:.:::.|.|:....|||::..|:.:..|...|...||.:  .||..||:|.|.|.|.|.
Mouse   127 LKLRCIQVQKIRYVWDFLKKRFQKVGLLEDSNSCFDIHHTFGLGLTNEEQEVRRLVCGPNSIEVE 191

  Fly   344 LRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQKTV 408
            ::....||..:|||||||||.|::.||.:..|..|:..|::::|..|.:||...::....|.|.|
Mouse   192 IQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLHKLV 256

  Fly   409 YNTGNAWV---VDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLTGESVP 470
            .......|   |..||| :||.:|.:|||||:.:|.. .:|.||||||.|:|:::|.||||||:|
Mouse   257 EEHNKVQVTITVRDKGL-QELESRLLVPGDILILPGK-ISLPCDAILIDGSCVVNEGMLTGESIP 319

  Fly   471 VTKTPLPSKRDMIFDKT----EHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSI 531
            |||||||...:.:..|:    ::.:|.|||||:|||.:......|.|.|:.||..||||:|:|||
Mouse   320 VTKTPLPQTENTMPWKSHSLEDYRKHVLFCGTEVIQVKPSAQGLVRAVVLQTGYNTAKGDLVRSI 384

  Fly   532 LYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAA 596
            |||.|:::|...|::||:.|||.:..|||.|.|...:.....|.:.|..:|.|::..|||.||||
Mouse   385 LYPRPLNFKLYNDAFKFMVFLACVGVVGFFYALGVYMYHEVPPRETATMALILLSATVPPVLPAA 449

  Fly   597 MTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQI-- 659
            :|:|..|||||||..:||||||:.||:.|.||..||||||||||||||:||.|| ::.|.||.
Mouse   450 LTIGNVYAQKRLKKEKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVP-TAGNCFQAVH 513

  Fly   660 PLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPT 724
            ...|.:.:|:......|.:|||:.:|:|.:.||||||||||.|||.:|||
Mouse   514 SFASGEAVPWGPLCAAMTSCHSLILLDGTIQGDPLDLKMFEGTGWNMEDS--------------- 563

  Fly   725 ILRQPRGGLSGMAETESGSKNEIK-RQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSV 788
               |......|||::.:..|...| .||.||.:.               |:|:|||:|.||||||
Mouse   564 ---QVASCKFGMADSSTVIKPGPKASQSPVDSIT---------------ILRQFPFSSGLQRMSV 610

  Fly   789 VTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKV 853
            :.:...|...:||.||:|||:.:.|:.:::|.|:||:|..:..:|:|:||:|.|.|       |:
Mouse   611 IAQLAGDLHLHVYMKGAPEMVARFCRSETVPKNFSQELRNYTVQGFRVIALAHKTL-------KM 668

  Fly   854 QRLS------REEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARD 912
            :|||      ||:||:.:.|||.:|:|||||.:|..|:..|:.|:|||:|:||||:.|||:||::
Mouse   669 ERLSDMDHLAREKVESELAFLGLLIMENRLKKETRPVLKELSEARIRTVMVTGDNLQTAITVAKN 733

  Fly   913 CGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFN 977
            ..::.....|:.|.|:..||.......              ::|..|.:.||
Mouse   734 SEMIPVGSQVVIVEANEPGDLVPASVT--------------WQLVGTQEPGS------------- 771

  Fly   978 SNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGI 1042
                           ||...:::..||.|......:
Mouse   772 ---------------GKKDTYIDIGNSSVPAGKGYH----------------------------- 792

  Fly  1043 KHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCV 1107
                          |||.||::|::..:|...:..:|..|:|:|||||.||.:||.|.|.|:|.|
Mouse   793 --------------FAMSGKSYQVLFHHFYSMLPQILVNGTIFARMSPGQKSSLVEEFQKLNYYV 843

  Fly  1108 AMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMA 1172
            .|||||||||||||:|||||||||.|||:||||||:...|..|..:|:|||||||:|||:|||:.
Mouse   844 GMCGDGANDCGALKMAHAGISLSEQEASVASPFTSKTANIECVPHLIREGRAALVSSFGVFKYLT 908

  Fly  1173 AYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPL 1237
            .|.::|||...:||.......:.|||..|:.:..:.:.......::. .|....|...|:|...|
Mouse   909 MYGIIQFIGTSLLYWQLQLFGNYQYLLQDVAITLMVSLTMSINHAYP-KLAPYRPAGQLLSPQLL 972

  Fly  1238 ASLLLHLTVVTAFQVTCWVHLHQQPWF-----------------KAFEPADEDHLG--------- 1276
            .|:.::.......||..::.:.||||:                 .|....|.:..|
Mouse   973 LSVFMNSCFTCIVQVCTFLTVKQQPWYCEVYKYSECFLVNQSNLSANVSLDRNWTGNATLVPASV 1037

  Fly  1277 -CFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNW--PLCLAFIVNLCIIV----YLVLY--- 1331
             .||..|::.|.:|..|..||:||||.|:|||:::|:  .|.||....|.|.:    :..||
Mouse  1038 LSFEGTTLWPIVTFNCISAAFIFSKGKPFRKPIYANYLFSLLLASAAGLTIFILFCDFQDLYRKM 1102

  Fly  1332 -----PSDW-----VASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQ---- 1382
                 |:.|     :|:|.|                         |..:|.||..|.:..:
Mouse  1103 EFIPTPTSWRVSILIAAFVQ-------------------------FCVAFFVEDAVLQNRELWLF 1142

  Fly  1383 VKREKNWVTSKQKYMRLEHDISNIKNWPPITEV-YEPNNLIDCETEQPTYVSLHAEQNHDTQLGK 1446
            :|:|..:. ||.:|..|:..::....|||:... |..|.      :...||:...|...:...||
Mouse  1143 IKKEFGFY-SKSQYRILQRKLAEDSTWPPVNRTDYAVNG------KNGFYVNRAYESPEEVPKGK 1200

  Fly  1447  1446
            Mouse  1201  1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	32/139 (23%)
		P-type_ATPase_cation	326..1281	CDD:319842	375/997 (38%)
Atp13a5	NP_783581.2	P5-ATPase	23..142	CDD:463565	31/133 (23%)
		P-type_ATPase_cation	174..999	CDD:319842	369/953 (39%)