DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and cta5

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_594863.1	Gene:	cta5 / 2542076	PomBaseID:	SPAC29A4.19c	Length:	1096	Species:	Schizosaccharomyces pombe

Alignment Length:	1213	Identity:	328/1213 - (27%)
Similarity:	536/1213 - (44%)	Gaps:	216/1213 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLVTEDYQGKHKMYHVKQIQVLTSSNLKTLLEK 247
            ||.|||.|:|.|.....|....:.||.|:.|.|.:: |..|             ||
pombe    57 LTLGLLHLILTWLPEFRLKWIEAPCSNEDVEFVAIS-DPSG-------------TS--------- 98

  Fly   248 EQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLN- 311
               |||:....|  ::|.:|     ||:........|.|..|:|         ||. :..|:|.
pombe    99 ---SIEKVSSIC--LKNDIQ-----TSSFVLPSGKTRYFEYKKL---------RFY-LEPLNLQW 143

  Fly   312 ----IPCSYY--------HQQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQL 364
                :..|.|        :.|.||........|.|:|.|.:....:...|:|..|||:|||:||.
pombe   144 VLMPLETSAYSLVTSTPAYIQNGLDTFTIAKLRQVYGSNSLVSTKKSIVTILLNEVLHPFYLFQA 208

  Fly   365 FSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTR 429
            .||::|....:.:|:|.|:.:|.:.|.:||.::|::::.:...:.......|:.:: :.:.:...
pombe   209 VSVLIWLCDSFVFYSCCIVFISSYSIFLSVKESKESENRIHSIIGAPQPVTVIRNQ-VKQTVLAD 272

  Fly   430 AIVPGDIIEIPSSGC-TLHCDAILISGNCILDESMLTGESVPVTKTPL-PSKRD--MIFDKTEHA 490
            .:|.||::...:... |...|.||.|.:|:|||||:||||||..|.|| .:..|  ||......:
pombe   273 DLVIGDLLYFSNLDLKTCPVDGILFSSSCLLDESMVTGESVPARKFPLEDNSLDSWMIASCNIFS 337

  Fly   491 RHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAII 555
            .|.:..|||.::.....|...|..|:.||..:.||:|||::|||.....:...||..|::.:||:
pombe   338 PHLIHAGTKFLKIDSTPSTPCLISVVRTGFRSNKGQLIRNLLYPNLRPSQLYLDSMSFLKTMAIL 402

  Fly   556 ACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRS 620
            :.|..::..:...|.......:.:.|||::||:|||||||.::||...:..||..:.|:..||.|
pombe   403 SFVSIVFIAIYLNLYNASFGHVVLRSLDVLTILVPPALPATLSVGIANSIARLSRALIYTTSPES 467

  Fly   621 INVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTN----QFQIPLKSVDRLPFDHFLFGMVTC-H 680
            |:.||.::...|||||||||:.:.:..|..||.:|    |......|:|....:...:.:.|| .
pombe   468 IHNAGCLSTFVFDKTGTLTENSVQLSCVYVKSGSNGLLKQVDADSLSLDSTKLNAHAYRVATCSQ 532

  Fly   681 SITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTI--LRQPRGGLSGMAETESGS 743
            |:.::...::||||::.:|               |:..|....||  ...|...|..::.:..|
pombe   533 SLELVGNELVGDPLEVTLF---------------TQFNGTFCATIRASNTPHPPLFSVSNSFDG- 581

  Fly   744 KNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEM 808
                                |||   ...|.:...|...|:||||:....:::...::.||:||.
pombe   582 --------------------PSQ---IFSIYKALEFDPVLRRMSVICSTSTERSLMLFTKGAPES 623

  Fly   809 LKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQ---RLSREEVENNMEFLGF 870
            :..:...||:|.|..:.:...:.||:||||.|.|.|     .|.:|   .|||..:|:|:.|.|.
pombe   624 ILAISSQQSIPSNVQEVIHTLSSKGFRIIAFASKNL-----ITPLQELIHLSRSTLESNVTFQGL 683

  Fly   871 VILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSAN 935
            .:||:.|:..:..||::|..:|:...:.:||::.|::.||:.||.:.....:.|..   :.||
pombe   684 FVLESPLRESSKDVISSLLRSKMEVSICSGDSLFTSVFVAKHCGALDSCNFIYTAE---LADS-- 743

  Fly   936 IQTNTGTECNFDNSSDKHYKLHY-TLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHM 999
                 |.:|.         ::|: .:||.::.              |.|
pombe   744 -----GDDCP---------QIHFEKIDLQTQN--------------FQP---------------- 764

  Fly  1000 ESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTW 1064
                              :|...||.     |.....|:.|                 .||||..
pombe   765 ------------------IPDGFSLK-----DVILEKDSSL-----------------CMDGKLL 789

  Fly  1065 QIVKDYFP-EEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGIS 1128
            |.:..... .|::|||::..:.|||||..|...|...|.....|..||||||||.|||.|..|:|
pombe   790 QRLLTMLSFNEIKILLSKLRVLARMSPFDKATYVELCQKYGCKVGFCGDGANDCIALKQADVGVS 854

  Fly  1129 LSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLT 1193
            ||::||..|:.|.|:..:|..|..|:.|||.:|:.|...|:||...::|||..|..||..:.|..
pombe   855 LSDSEACAAASFVSKKKSIKDVFNVLLEGRCSLILSHRCFQYMVLCAIVQFSGVFFLYLKNYNFN 919

  Fly  1194 DKQYLYVDLGLI---SIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCW 1255
            |.|:|::||.:|   |....:|...::    |....|.|:|.....:..|.:...::........
pombe   920 DNQFLFMDLLIIFPLSAAMSYFDPAQN----LTSNRPNSTLFGKGRVKDLGIQSVLIWLSHGLLT 980

  Fly  1256 VHLHQQPWFKAFE-PADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWP-LCLAF 1318
            :.||:..|.:..| ..::.:.......::|.:||.||:.:....::.:.:..|:|.... :||..
pombe   981 LILHELNWVELPEWQLEKSNTKNVLVTSIFLLSSLQYLGICIGINQSSEFLSPIWKKKTYVCLCT 1045

  Fly  1319 IVNLCIIVYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAAS 1361
            .:.||.|.......:..::...|:...||: :|:::|..|..|
pombe  1046 TIGLCNIYLCFANENHIISRCLQITRLPTL-YRFIILFMGVIS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	29/107 (27%)
		P-ATPase-V	173..1355	CDD:273738	325/1205 (27%)
		E1-E2_ATPase	381..621	CDD:278548	76/243 (31%)
		Cation_ATPase	<758..813	CDD:289987	14/54 (26%)
		HAD_like	<1087..1137	CDD:304363	26/49 (53%)
cta5	NP_594863.1	P-ATPase-V	33..1083	CDD:273738	326/1207 (27%)
		Cation_ATPase_N	143..214	CDD:279080	21/70 (30%)
		E1-E2_ATPase	226..468	CDD:278548	76/242 (31%)
		Cation_ATPase	<592..629	CDD:289987	10/36 (28%)
		COG4087	<809..>853	CDD:226572	21/43 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm47004
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880