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Protein Alignment anne and Atp7a

DIOPT Version :10

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_434690.1	Gene:	Atp7a / 24941	RGDID:	2179	Length:	1492	Species:	Rattus norvegicus

Alignment Length:	1272	Identity:	232/1272 - (18%)
Similarity:	428/1272 - (33%)	Gaps:	383/1272 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TVHLQSLPNHIEDLKFRNSDVETDDDLHFPGIAAKNKILKLSWWHSPVDMHYVATESVQPK---- 75
            |:....|....|.|:      |..:|:.|..:.             |.||........||.
  Rat   418 TIEYDPLLTSPEPLR------EAIEDMGFDAVL-------------PADMKEPLVVIAQPSLETP 463

  Fly    76 --KSDKVPSNKIKKVENNNTL-VNGCSKTSARSVPLLKYNRPDQDGDSEENITSVLEPNVDEIYS 137
              .|...|.|.:..|:|...: |:|  .|.|..|..::.|.     ..||.|.|||   |..:..
  Rat   464 LLPSTTEPENVMTPVQNKCYIQVSG--MTCASCVANIERNL-----RREEGIYSVL---VALMAG 518

  Fly   138 KDSERLVDDSKPCIGLLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTG---GLLRLVLHWWRHLY 199
            |...|           .||.......:....|.|   ||....:...|   |:|.||:..
  Rat   519 KAEVR-----------YNPAVIQPRVIAELIREL---GFGAVVMENAGEGNGILELVVRG----- 564

  Fly   200 LYATCSQCSLEEAEQVLVTEDYQGKHKMYHVKQIQVLTSSNLKTLLEKEQQSIERTHIECDH--- 261
              .||:.| :.:.|..|.      |||......:.:.|:               :.||:.|.
  Rat   565 --MTCASC-VHKIESTLT------KHKGIFYCSVALATN---------------KAHIKYDPEII 605

  Fly   262 -----VENVLQLSVHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQR 321
                 :..:..|.  |.::..||..|......|:.:..|     |...:..|...||.      .
  Rat   606 GPRDIIHTIGNLG--FEASLVKKDRSANHLDHKREIKQW-----RGSFLVSLFFCIPV------M 657

  Fly   322 GLPVHEQIS----RRIVFGDNEITVPLRDFKTLLFLE--VLNPFYVFQLFSVIL---------WF 371
            ||.::..:.    ..:....|.....:.:..:.:|||  :|....:..|.|::|         |:
  Rat   658 GLMIYMMVMDHHLATLNHNQNMSNEEMINMHSSMFLERQILPGLSIMNLLSLLLCLPVQFCGGWY 722

  Fly   372 TYDYYY-----------------------YACVILLMSVF-----------------------GI 390
            .|...|                       |:.||||::::                       |.
  Rat   723 FYIQAYKALRHKTANMDVLIVLATTIAFAYSLVILLVAMYERAKVNPITFFDTPPMLFVFIALGR 787

  Fly   391 TVSVLQTKKNQDVLQKTV-YNTGNAWVV----DHKGLSKE-LPTRAIVPGDIIEIPSSGCTLHCD 449
            .:..:...|..:.|.|.: .....|.:|    ::..||:| :....:..||||::...| ....|
  Rat   788 WLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGG-KFPVD 851

  Fly   450 AILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAF 514
            ..:|.|:.::|||::|||::||.|.|         ..|..|......|:.:|:..::|:...|:.
  Rat   852 GRVIEGHSMVDESLITGEAMPVAKKP---------GSTVIAGSINQNGSLLIRATHVGADTTLSQ 907

  Fly   515 VINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLV-------------- 565
            ::   .:..:.:..::     |:....::.|..|:.|:.:::.|..:..::
  Rat   908 IV---KLVEEAQTSKA-----PIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVEAYFP 964

  Fly   566 ---TKILRGTDPVKIAVE-SLDLITIVVPPAL----PAAMTVGRFYAQKR---LKTSEIFCISPR 619
               ..|.|....::.|.: |:.::.|..|.:|    |.|:.||.....:.   :|..|
  Rat   965 GYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGE------- 1022

  Fly   620 SINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKS--VDRLPF-----------DH 671
            .:.:|..:....||||||:|. |..:        .||.::.::|  :.|...           :|
  Rat  1023 PLEMAHKVKVVVFDKTGTITH-GTPV--------VNQVKVLVESNKISRNKILAIVGTAESNSEH 1078

  Fly   672 FLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGM 736
            .|...||.:....|:...:|...|.::....|...:.:|      ..|:|:.:.|:.
  Rat  1079 PLGAAVTKYCKQELDTETLGTCTDFQVVPGCGISCKVTN------IEGLLHKSNLKI-------- 1129

  Fly   737 AETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVY 801
                  .:|.||..|.|.........|||               |::...:.::..::.|.:.|.
  Rat  1130 ------EENNIKNASLVQIDAINEQSSPS---------------SSMIIDAHLSNAVNTQQYKVL 1173

  Fly   802 CKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNME 866
            ......|::   ....:.::..:.:.|..::|...:.:..                      :.|
  Rat  1174 IGNREWMIR---NGLVISNDVDESMIEHERRGRTAVLVTI----------------------DDE 1213

  Fly   867 FLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGI------VSPSQSV--- 922
            ..|.:.:.:.:||:....::.|.:..:..:::||||..||.|:|...||      |.||..|
  Rat  1214 LCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKV 1278

  Fly   923 ---------ITVHADPIGD-------SANIQTNTGTECNFDNSS-----DKHYKLHYTLDLGSKT 966
                     :.:..|.|.|       |..|...|||:...:.:.     :....:..::||..||
  Rat  1279 KQLQEEGKRVAMVGDGINDSPALAMASVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKT 1343

  Fly   967 SRA----YLFKSCFN-------SNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAES---- 1016
            .:.    ::|...:|       :.:|.|        :|..:.....:.::...|.|....|
  Rat  1344 VKRIRINFVFALIYNLIGIPIAAGVFLP--------IGLVLQPWMGSAAMAASSVSVVLSSLFLK 1400

  Fly  1017 --GLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILL 1079
              ..||.|:........|...:.:|:.:....|::.|....:..:|    :||.          .
  Rat  1401 LYRKPTYDNYELRPRSHTGQRSPSEISVHVGIDDTSRNSPRLGLLD----RIVN----------Y 1451

  Fly  1080 TRGSIYARMS------------PDQKQALVIELQNLD 1104
            :|.||.:.:|            ||:...||.:.:..|
  Rat  1452 SRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDD 1488

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.