DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment anne and atp1a1a.5

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_835200.1	Gene:	atp1a1a.5 / 245703	ZFINID:	ZDB-GENE-020501-1	Length:	1023	Species:	Danio rerio

Alignment Length:	984	Identity:	208/984 - (21%)
Similarity:	349/984 - (35%)	Gaps:	284/984 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 GLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPL-------------RDFKTLLFLEVLNP 358
            |.||.         :||||...:...:..|.|.:|.|:             ..|:|||::.....
Zfish    57 GTDLT---------KGLPVSRAMEVLMRDGPNALTPPVITPEWVRFCRQLFGGFQTLLWIGAFLC 112

  Fly   359 FYVFQLFSVILWFTYDYYYYACVILLMSVFGITVS-------------VLQTKKNQDVLQKTVYN 410
            ::.|.:.:.......|..|...|:    .|.:||:             ::.:.||. |.||.
Zfish   113 YFAFSIQAATEEPVNDNLYLGIVL----TFVVTVNGCFSYSQEAKSCRIMDSFKNL-VPQKA--- 169

  Fly   411 TGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGN-CILDESMLTGESVPVTKT 474
                 :|...|..|.:....:|.||::|: ..|..:..|..::|.: |.:|.|.|||||.|..:|
Zfish   170 -----LVVRDGEKKIIDAEEVVVGDLVEV-KGGDKIPADIRIVSSHGCKVDNSSLTGESEPQIRT 228

  Fly   475 PLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGEL--IRSILY--PP 535
            |     ||..:.....|:..|..|..|.    |:.:  ..|:|||:.|..|.:  :.|.|.  ..
Zfish   229 P-----DMSSENPLETRNIAFFSTNCID----GAAR--GIVVNTGDRTVMGRIASLASNLEGGQT 282

  Fly   536 PVDYKFEQDSYKFIQFLAIIACVG-FIYT--LVTKILRGTDPVKIAVESLDLITIVVPPALPAAM 597
            |:..:.|       .|:.||..|. |:.|  |:..::.|...::..:..:.||...||..||..:
Zfish   283 PLGREIE-------HFIHIITGVAVFLGTTFLIISVMLGFTWLEGIIFLIGLIVANVPEGLPCTV 340

  Fly   598 TVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGL---DMWGVVPKSSTNQFQI 659
            ||......|.:........:..::...||.:..|.|||||||::.:   .||      ..||..|
Zfish   341 TVALTLTAKHMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW------FDNQIHI 399

  Fly   660 --PLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILY 722
              ..::.....||.   ...|..::..:.|.     .:..:|:|      :.:::|
Zfish   400 ADTTENQTGASFDR---SSATWSALARVAGL-----CNRAVFQS------NQSHLP--------- 441

  Fly   723 PTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTS-ALQRM 786
              :||:         || :|..:|......::  |....::..::|:..  |.|.||.| :..::
Zfish   442 --VLRR---------ET-AGDASESALLKCIE--LCCGSVTGMRENYPK--VAEIPFNSISKYQL 490

  Fly   787 SVVTRCLSDQVFN-VYCKGSPEMLKKLC-------KPQSLPDNYSQQLS----EFAKKGYRIIAI 839
            |:.....|.:..: :..||:||.:...|       |...|.|...:...    :....|.|::..
Zfish   491 SIHENPNSSEPKHLLVMKGAPERILDRCSTILIEGKEHPLDDEMKEDFQNAYVQLGGLGERVLGF 555

  Fly   840 AFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGD 901
            ....|... .:.:......||:....|.|.||.|.:.:.|....|.:|:   .:|.|:.||:|||
Zfish   556 CHFCLPDD-QFPEGFAFDTEEMNFPTENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGD 619

  Fly   902 NILTAISVARDCGIVSPSQSVI-------TVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYT 959
            :.:||.::|:..||:|.....:       .:|.|.:                 |..|.
Zfish   620 HPITAKAIAKGVGIISEGNETVDDIAARLKIHIDEV-----------------NPRDA------- 660

  Fly   960 LDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSL 1024
                         |:|                    :.|
Zfish   661 -------------KAC--------------------VIH-------------------------- 666

  Fly  1025 ASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMS 1089
                        ..||  |:..||.                 :.|......||      ::||.|
Zfish   667 ------------GGEL--KNMTDEQ-----------------LDDVLQHHTEI------VFARTS 694

  Fly  1090 PDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVL 1151
            |.||..:|...|.....||:.|||.||..|||.|..|:::....:.:   |:.....:...::::
Zfish   695 PQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIV 759

  Fly  1152 KVIKEGRAALVTSFGIFKYMAAYSLVQFISVM------ILYSIDSNLTDKQYLYVDLG--LISIF 1208
            ..::|||..    |...|....|:|...|..|      :|..|...|.....|.:|||  ::...
Zfish   760 TGVEEGRLI----FDNLKKSICYTLSTKIPEMSPFLMFVLAGIPLPLGTVTILCIDLGTDMVPAI 820

  Fly  1209 AFFFGKTES 1217
            :|.:...||
Zfish   821 SFAYENAES 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	208/984 (21%)
		E1-E2_ATPase	381..621	CDD:278548	64/260 (25%)
		Cation_ATPase	<758..813	CDD:289987	12/56 (21%)
		HAD_like	<1087..1137	CDD:304363	19/52 (37%)
atp1a1a.5	NP_835200.1	ATPase-IIC_X-K	32..1023	CDD:273445	208/984 (21%)
		Cation_ATPase_N	41..115	CDD:214842	15/66 (23%)
		E1-E2_ATPase	134..365	CDD:278548	64/262 (24%)
		Cation_ATPase	427..521	CDD:289987	23/129 (18%)
		COG4087	603..752	CDD:226572	49/268 (18%)
		Cation_ATPase_C	799..1008	CDD:279079	8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910