DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp4a

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_036641.1	Gene:	Atp4a / 24216	RGDID:	2177	Length:	1034	Species:	Rattus norvegicus

Alignment Length:	1278	Identity:	253/1278 - (19%)
Similarity:	442/1278 - (34%)	Gaps:	405/1278 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 GKHKMYHVKQIQVLT--SSNLKTLLE---------KEQQSIERTHIEC---DHVENVLQLSVHFT 273
            ||.:.|.:..:::.|  ..|:...:.         |:::.:|....|.   ||..:|.:|...:.
  Rat     2 GKAENYELYSVELGTGPGGNMAAKMSKKKAGGGGGKKKEKLENMKKEMEMNDHQLSVSELEQKYQ 66

  Fly   274 SAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDN 338
            ::..|   .::.....:|:.....|..|                 ..||.|.:.:.:|::..|
  Rat    67 TSATK---GLKASLAAELLLRDGPNALR-----------------PPRGTPEYVKFARQLAGG-- 109

  Fly   339 EITVPLRDFKTLLFLEVLNPFYVFQLFSVILW---------FTYDYYYYA----CVILLMSVFGI 390
                          |:.|  .:|.....:|.:         .|.|..|.|    .|:::...||.
  Rat   110 --------------LQCL--MWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGY 158

  Fly   391 -----TVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCD- 449
                 :.:::.:.||....|.||...|:.:         ::....:|.||::|: ..|..:..|
  Rat   159 YQEFKSTNIIASFKNLVPQQATVIRDGDKF---------QINADQLVVGDLVEM-KGGDRVPADI 213

  Fly   450 AILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAF 514
            .||.:..|.:|.|.|||||.|.|::|     :...:.....|:..|..|..::    |:.:.|
  Rat   214 RILSAQGCKVDNSSLTGESEPQTRSP-----ECTHESPLETRNIAFFSTMCLE----GTAQGL-- 267

  Fly   515 VINTGNITAKGELIRSIL-----YPPPVDYKFEQDSYKFIQFLAIIA------------CVGFIY 562
            |::||:.|..|. |.|:.     ...|:..:.|.    |:..:|.:|            |:|:.:
  Rat   268 VVSTGDRTIIGR-IASLASGVENEKTPIAIEIEH----FVDIIAGLAILFGATFFVVAMCIGYTF 327

  Fly   563 TLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSI 627
                        ::..|..:.::...||..|.|.:||......|||.:......:..::...||.
  Rat   328 ------------LRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGST 380

  Fly   628 NCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGD 692
            :..|.|||||||::.:                   :|..|.||:.:....|..
  Rat   381 SVICSDKTGTLTQNRM-------------------TVSHLWFDNHIHTADTTE------------ 414

  Fly   693 PLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKN-EIKRQSSVDDL 756
                   :.:|...:.|     :|.:..|...:.      |...|..:||... .:.::..:.|.
  Rat   415 -------DQSGQTFDQS-----SETWRALCRVLT------LCNRAAFKSGQDAVPVPKRIVIGDA 461

  Fly   757 LATVGISPSQKNFDHGI--------VREFPFTSALQ-RMSVVT-RCLSDQVFNVYCKGSPEMLKK 811
            ..|..:..|:....:.:        |.|.||.|..: ::|:.| ....|....:..||:||.:.:
  Rat   462 SETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLE 526

  Fly   812 LC-----KPQSLPDNYSQQLSEFAKKGY--------RIIAIAFKALSHKMNYTKVQRLSREEVEN 863
            .|     |.|.||  ..:|..|..:..|        |::......|:.| :|........|.:..
  Rat   527 RCSSILIKGQELP--LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEK-DYPPGYTFDVEAMNF 588

  Fly   864 NMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITV 925
            ....|.|..|.:.:.|....|.:|:   ..|.||.||:|||:.:||.::|...||:|.
  Rat   589 PSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISE------- 646

  Fly   926 HADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTA 990
                                                 ||:|
  Rat   647 -------------------------------------GSET------------------------ 650

  Fly   991 QVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVK-TIDTWTHNDAELGIKHTPDESWRRQE 1054
                                         ..|..|.:: .:|.....||              :.
  Rat   651 -----------------------------VEDIAARLRMPVDQVNKKDA--------------RA 672

  Fly  1055 CIFAMDGKTWQIVKDYFPEEM-EILLTRGS-IYARMSPDQKQALVIELQNLDYCVAMCGDGANDC 1117
            |:  ::|..   :||..|.|: |.|.|... ::||.||.||..:|...|.|...||:.|||.||.
  Rat   673 CV--INGMQ---LKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDS 732

  Fly  1118 GALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTS-------FGIFKYMAAYS 1175
            .|||.|..|:::     .||....::|   :|.:.::.:..|::||.       |...|...||:
  Rat   733 PALKKADIGVAM-----GIAGSDAAKN---AADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYT 789

  Fly  1176 LVQFISVMILYSIDSNLTDKQYLYVD----LGLISIF------------AFFFGKTESFDGMLVE 1224
            |.:.|..:..|.|        |:.|.    ||.|:|.            :..:.|.||....|..
  Rat   790 LTKNIPELTPYLI--------YITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRP 846

  Fly  1225 QVPLSSLISSTPLASL-LLHLTVVTAFQ--VTCWVHLHQQPWFK----AFEPADEDH-------- 1274
            :.|....:.:.|||:. ...:..:.:|.  ...:..:.|:.||.    ...|..|||
  Rat   847 RNPRRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDS 911

  Fly  1275 --------------LGCFENYTMFCISSFQYIILAFVFSKG---APYRKPLWSNWPLCLAFIVNL 1322
                          ..|   ||:|.||.....|...:..|.   :.:::..:.|..|.:|.:..:
  Rat   912 YGQEWTFGQRLYQQYTC---YTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQV 973

  Fly  1323 CIIVYLVLYPSDWVASFFQLIVPPTMRFRY--VMLAYGAASFI 1363
            ||..:|...|.  :.:.|..:   .:||::  |.:.:|...|:
  Rat   974 CIGCFLCYCPG--MPNIFNFM---PIRFQWWLVPMPFGLLIFV 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	13/81 (16%)
		P-ATPase-V	173..1355	CDD:273738	251/1268 (20%)
		E1-E2_ATPase	381..621	CDD:278548	57/262 (22%)
		Cation_ATPase	<758..813	CDD:289987	14/64 (22%)
		HAD_like	<1087..1137	CDD:304363	20/49 (41%)
Atp4a	NP_036641.1	H-K_ATPase_N	2..>27	CDD:286172	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40		3/24 (13%)
		ATPase-IIC_X-K	42..1034	CDD:273445	247/1238 (20%)
		Cation_ATPase_N	50..124	CDD:214842	16/111 (14%)
		E1-E2_ATPase	145..375	CDD:278548	57/267 (21%)
		Cation_ATPase	437..531	CDD:289987	20/93 (22%)
		COG4087	<687..>742	CDD:226572	24/54 (44%)
		Cation_ATPase_C	809..1018	CDD:279079	41/211 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930