Protein Alignment anne and Atp2b2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_063141551.1
• Gene: Atp2b2 / 24215
• RGDID: 2176
• Length: 1272
• Species: Rattus norvegicus
• Alignment Length: 1248
• Identity: 240/1248 - (19%)
• Similarity: 396/1248 - (31%)
• Gaps: 463/1248 - (37%)

  Fly   322 GLP--VHEQISRRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY---- 377
            |||  ..:...|:.:||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|:
  Rat    67 GLPGTAPDLEKRKQIFGQN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGE 129

  Fly   378 -----------------------YACVILLMSVFGITVSV------------LQTKKNQDVLQK- 406
                                   ....|||..:..:.|:.            ||::..|:  ||
  Rat   130 SNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQE--QKF 192

  Fly   407 TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVP 470
            ||...|.  ||       ::|...||.|||.:| ..|..|..|.:.|.||.: :|||.|||||..
  Rat   193 TVVRAGQ--VV-------QIPVAEIVVGDIAQI-KYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247

  Fly   471 VTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVI----NTGNI---------- 521
            |.|:         .||..    .|..||.|::    ||.:::...:    .||.|
  Rat   248 VRKS---------VDKDP----MLLSGTHVME----GSGRMVVTAVGVNSQTGIIFTLLGAGGEE 295

  Fly   522 ------------------------------TAKGELIRSILYPPPVD------------------ 538
                                          :|...|:...:.....|
  Rat   296 EEKKDKKGVKKGDGLQLPAADGAAPANAAGSANASLVNGKMQDGSADSSQSKAKQQDGAAAMEMQ 360

  Fly   539 ------------------YKFEQD--SYKFIQFLAIIACVGFIYTLVTKI--------------- 568
                              :|.|:.  ..|..:....|...|.:.:.:|.|
  Rat   361 PLKSAEGGDADDKKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNK 425

  Fly   569 ---LRGTDP------VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVA 624
               |....|      ||..:..:.::.:.||..||.|:|:...|:.|::...........:....
  Rat   426 KPWLTECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM 490

  Fly   625 GSINCCCFDKTGTLTEDGLDM---------WGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCH 680
            |:....|.|||||||.:.:.:         :..:|..|:    |..|:::.|           .:
  Rat   491 GNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSS----INAKTLELL-----------VN 540

  Fly   681 SITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKN 745
            :|.|.:..                    :..|...||.|.|...:..:...||.|..........
  Rat   541 AIAINSAY--------------------TTKILPPEKEGALPRQVGNKTECGLLGFVLDLRQDYE 585

  Fly   746 EIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPE-ML 809
            .::.|            .|.:|     :.:.:.|.|..:.||.|.: :.|:.|.:|.||:.| :|
  Rat   586 PVRSQ------------MPEEK-----LYKVYTFNSVRKSMSTVIK-MPDESFRMYSKGASEIVL 632

  Fly   810 KKLCK------------PQSLPDNYSQQLSEFAKKGYRIIAIAFKAL--SHKMNYTKVQRLSREE 860
            ||.||            |:...:...:.:...|..|.|.|.:|::..  |.:.::.     :..:
  Rat   633 KKCCKILSGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWD-----NEND 692

  Fly   861 VENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITV 925
            :.|.:..:..|.:|:.::|:..:.|.....|.|...|:|||||.||.::|..|||:.|.:
  Rat   693 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE----- 752

  Fly   926 HADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTA 990
                                                                         :|..
  Rat   753 -------------------------------------------------------------DFLC 756

  Fly   991 QVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQEC 1055
            ..||     |....:.||.                            .|:           .||.
  Rat   757 LEGK-----EFNRRIRNEK----------------------------GEI-----------EQER 777

  Fly  1056 IFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALV---IELQNLD--YCVAMCGDGAN 1115
            |    .|.|..::               :.||.||..|..||   |:..:.:  ..||:.|||.|
  Rat   778 I----DKIWPKLR---------------VLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTN 823

  Fly  1116 DCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLV 1177
            |..|||.|..|.::......:   ||.....:...|:::|.:..||....:   |.|::.....|
  Rat   824 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTV 885

  Fly  1178 QFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISS 1234
            ..::|::.:     :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   ..|||.
  Rat   886 NVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTETLLLRKPYGRNKPLISR 949

  Fly  1235 TPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFS 1299
            |.:.::|.|    ..:|:|....|                  .|....||.|.|          .
  Rat   950 TMMKNILGH----AVYQLTLIFTL------------------LFVGEKMFQIDS----------G 982

  Fly  1300 KGAPYRKPLWSNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFR 1351
            :.||...|...::.:    |.|..:::.|.             ::...:....|..||..|...:
  Rat   983 RNAPLHSPPSEHYTI----IFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQ 1043

  Fly  1352 YVMLAYGAASFIC 1364
            .|::.:|...|.|
  Rat  1044 IVIVQFGGKPFSC 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	219/1144 (19%)
Atp2b2	XP_063141551.1	None