DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp1a3

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_017444264.1	Gene:	Atp1a3 / 24213	RGDID:	2169	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	954	Identity:	199/954 - (20%)
Similarity:	336/954 - (35%)	Gaps:	265/954 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 GDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWF-------------------TYDYYYYACV 381
            |.|.:|.|....:.:.|...|     |..||::||.                   :.|..|...|
  Rat    79 GPNALTPPPTTPEWVKFCRQL-----FGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIV 138

  Fly   382 ILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTL 446
            :..:.:.....|..|..|:..:::..........:|..:|...::....:|.||::|| ..|..:
  Rat   139 LAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEI-KGGDRV 202

  Fly   447 HCDAILISGN-CILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKK 510
            ..|..:||.: |.:|.|.|||||.|.|::|     |...|.....|:..|..|..::    |:.:
  Rat   203 PADLRIISAHGCKVDNSSLTGESEPQTRSP-----DCTHDNPLETRNITFFSTNCVE----GTAR 258

  Fly   511 VLAFVINTGNITAKGEL--IRSILY--PPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRG 571
              ..|:.||:.|..|.:  :.|.|.  ..|:..:.|.    |||.:..:|....:...:..::.|
  Rat   259 --GVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEH----FIQLITGVAVFLGVSFFILSLILG 317

  Fly   572 TDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTG 636
            ...::..:..:.:|...||..|.|.:||......||:........:..::...||.:..|.||||
  Rat   318 YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTG 382

  Fly   637 TLTEDGL---DMW--GVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDL 696
            |||::.:   .||  ..:.::.|.:.|      ....||......|....|..|..|
  Rat   383 TLTQNRMTVAHMWFDNQIHEADTTEDQ------SGTSFDKSSHTWVALSHIAGLCNR-------- 433

  Fly   697 KMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMA-----ETESGSKNEIKRQSSVDDL 756
            .:|:.      ..:||          |.:.|...|..|..|     |..|||...::.::..
  Rat   434 AVFKG------GQDNI----------PVLKRDVAGDASESALLKCIELSSGSVKLMRERNKK--- 479

  Fly   757 LATVGISPSQKNFDHGIVREFPFTSALQ-RMSV-VTRCLSDQVFNVYCKGSPEMLKKLC------ 813
                             |.|.||.|..: ::|: .|...:|..:.:..||:||.:...|
  Rat   480 -----------------VAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCATILLQ 527

  Fly   814 -KPQSLPDNYSQQLS----EFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVIL 873
             |.|.|.:...:...    |....|.|::......|..: .:.|......::|....:.|.||.|
  Rat   528 GKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEE-QFPKGFAFDCDDVNFTTDNLCFVGL 591

  Fly   874 ENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSAN 935
            .:.:.|....|.:|:   .:|.|:.||:|||:.:||.::|:..||:|...
  Rat   592 MSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGN--------------- 641

  Fly   936 IQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHME 1000
                                                            ||.|..|
  Rat   642 ------------------------------------------------ETVEDIA---------- 648

  Fly  1001 STNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQ 1065
                         |...:|.|..          ...||:..:.|..|
  Rat   649 -------------ARLNIPVSQV----------NPRDAKACVIHGTD------------------ 672

  Fly  1066 IVKDYFPEEMEILLTRGS--IYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGIS 1128
             :||:..|:::.:|...:  ::||.||.||..:|...|.....||:.|||.||..|||.|..|::
  Rat   673 -LKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVA 736

  Fly  1129 LSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSL---VQFISVMILYS 1187
            :....:.:   |:.....:...::::..::|||..    |...|...||:|   :..|:..:|:
  Rat   737 MGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSNIPEITPFLLF- 796

  Fly  1188 IDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSL 1231
            |.:|:.      :.||.|:|.....|         .:.||..||
  Rat   797 IMANIP------LPLGTITILCIDLG---------TDMVPAISL 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	199/954 (21%)
		E1-E2_ATPase	381..621	CDD:278548	55/244 (23%)
		Cation_ATPase	<758..813	CDD:289987	12/56 (21%)
		HAD_like	<1087..1137	CDD:304363	19/52 (37%)
Atp1a3	XP_017444264.1	ATPase-IIC_X-K	31..1026	CDD:273445	199/954 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000