DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp2c1

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001240760.1	Gene:	Atp2c1 / 235574	MGIID:	1889008	Length:	952	Species:	Mus musculus

Alignment Length:	1253	Identity:	253/1253 - (20%)
Similarity:	425/1253 - (33%)	Gaps:	413/1253 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 YQGKHKMYHVKQIQVLTSSNLKTL-LEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIR 284
            |..|:.::.:::.       |.|| .::.::.:.|.. :..:|||...:.| .||   |:.|.:.
Mouse    12 YLKKYPLHSIRKY-------LSTLRSQRAEEQVARFQ-KIPNVENETMIPV-LTS---KRASELA 64

  Fly   285 IFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITV----PL- 344
            :.....|:.|              ||         |.||...|...||...|.||..:    ||
Mouse    65 VSEVAGLLQA--------------DL---------QNGLNKSEVSHRRAFHGWNEFDISEDEPLW 106

  Fly   345 ----RDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQ 405
                ..||        ||..:..|.|.::......:..|..|.:..|..:||:.:|..:::..|:
Mouse   107 KKYISQFK--------NPLIMLLLASAVISILMRQFDDAVSITVAIVIVVTVAFVQEYRSEKSLE 163

  Fly   406 KTVYNTGNAWVVDHKGLSKELP---------------TRAIVPGDIIEIPSSGCTLHCDAILISG 455
            :               |||.:|               .|.:||||.:.: |.|..:..|..|...
Mouse   164 E---------------LSKLVPPECHCVREGKLEHTLARDLVPGDTVCL-SVGDRVPADLRLFEA 212

  Fly   456 -NCILDESMLTGESVPVTK--TPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVIN 517
             :..:|||.||||:.|.:|  .|.|:....:..::..|    |.||      .:...|....||.
Mouse   213 VDLSVDESSLTGETAPCSKVTAPQPAANGDLASRSNIA----FMGT------LVRCGKAKGIVIG 267

  Fly   518 TGNITAKGELIRSIL--------YPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDP 574
            ||..:..||:.:.:.        ....:|...:|.|:.....:.||..||:        |.|.|.
Mouse   268 TGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGW--------LLGKDI 324

  Fly   575 VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCC---CFDKTG 636
            :::...|:.|....:|..||..:||.......|:.......   :.:.:..::.||   |.||||
Mouse   325 LEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIV---KKLPIVETLGCCNVICSDKTG 386

  Fly   637 TLTE-----------DGL--DMWGVVPKSSTNQFQIPLKSVDRLPFDHFLF----------GMVT 678
            |||:           |||  ::.||    ..|||...:...|.:   |..:          |.|
Mouse   387 TLTKNEMTVTHILTSDGLHAEVTGV----GYNQFGEVIVDGDVV---HGFYNPAVSRIVEAGCV- 443

  Fly   679 CHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGS 743
            |:...|.|..:||.|.:                       |.|....::.   ||.|:.:
Mouse   444 CNDAVIRNNTLMGKPTE-----------------------GALIALAMKM---GLDGLQQ----- 477

  Fly   744 KNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSV--VTRCLSDQVFNVYCKGSP 806
                                      |:....|:||:|..:.|:|  |.|...|:....:.||:.
Mouse   478 --------------------------DYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAY 516

  Fly   807 EMLKKLC-----KPQSLP------DNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREE 860
            |.:.|.|     |.|:|.      |.|.|:.:.....|.|::|:|                |..|
Mouse   517 EQVIKYCTTYNSKGQTLALTQQQRDLYQQEKARMGSAGLRVLALA----------------SGPE 565

  Fly   861 VENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITV 925
            : ..:.|||.|.:.:..:....:.:..|.|:.:...|||||:..|||::|...|
Mouse   566 L-GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAIAIASRLG----------- 618

  Fly   926 HADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTA 990
                                                |.||||::
Mouse   619 ------------------------------------LYSKTSQS--------------------- 626

  Fly   991 QVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQEC 1055
                                              .|.:.:||       :.::|
Mouse   627 ----------------------------------VSGEEVDT-------MEVQH----------- 639

  Fly  1056 IFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGAL 1120
                               :..::.:.:::.|.||..|..::..||.....|||.|||.||..||
Mouse   640 -------------------LSQIVPKVAVFYRASPRHKMKIIKSLQKNGAVVAMTGDGVNDAVAL 685

  Fly  1121 KVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAAL--VTSFGIFKYMAAYSLVQFI 1180
            |.|..|:::.:|...:   |:.....:.....::..|:||:...  :.:|..|:...:.:.:..|
Mouse   686 KAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLI 750

  Fly  1181 SVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL----SSLISSTPLASLL 1241
            |:..|.:..:.|...|.|::::.:....|...| .|..|..::.:.|.    |.|..:..|..|:
Mouse   751 SLATLMNFPNPLNAMQILWINIIMDGPPAQSLG-VEPVDKDVIRKPPRNWKDSILTKNLILKILV 814

  Fly  1242 LHLTVVTAFQVTCWVHLHQQPWFKAFEPADED-HLGCFENYTMF-CISSFQYIILAFVFSKGAPY 1304
            ..:.:|.......|..|..    ....|.|.. ...||..:.|| .:||...  ...||..|
Mouse   815 SSIIIVCGTLFVFWRELRD----NVITPRDTTMTFTCFVFFDMFNALSSRSQ--TKSVFEIG--- 870

  Fly  1305 RKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVE 1369
               |.||...|.|.:.::...:.::.:|.  :...||   ..::....::...|..|.:| |..|
Mouse   871 ---LCSNKMFCYAVLGSIMGQLLVIYFPP--LQKVFQ---TESLSILDLLFLLGLTSSVC-IVSE 926

  Fly  1370 SFLVEYLVFKKYQVKREK 1387
                   :.||.:..|||
Mouse   927 -------IIKKVERSREK 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	14/70 (20%)
		P-ATPase-V	173..1355	CDD:273738	243/1219 (20%)
		E1-E2_ATPase	381..621	CDD:278548	59/265 (22%)
		Cation_ATPase	<758..813	CDD:289987	14/56 (25%)
		HAD_like	<1087..1137	CDD:304363	20/52 (38%)
Atp2c1	NP_001240760.1	ATPase-IIA2_Ca	57..936	CDD:130585	239/1196 (20%)
		Cation_ATPase_N	60..128	CDD:279080	22/98 (22%)
		E1-E2_ATPase	152..372	CDD:278548	55/256 (21%)
		Cation_ATPase	443..526	CDD:289987	27/140 (19%)
		COG4087	589..712	CDD:226572	42/261 (16%)
		Cation_ATPase_C	759..931	CDD:279079	40/197 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910