Protein Alignment anne and ATP13A2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Alignment Length: 1209
• Identity: 439/1209 - (36%)
• Similarity: 631/1209 - (52%)
• Gaps: 167/1209 - (13%)

  Fly   137 SKDSERLVDDSKPCIGLLN--------PDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLH 193
            |.||..||..:....|.|.        ......:::.||..|..|.......:::..| :.|:|.
Human     2 SADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAG-IPLLLF 65

  Fly   194 WWRHLY-LYATCSQCSLEEAEQVLVTEDYQGKHKMYHVKQIQVLTSSNLKTLLEKEQQSIERTHI 257
            .|:.|: :......|:|..|| .||.|....:...:.:..:||.|.:..:..||...||
Human    66 RWKPLWGVRLRLRPCNLAHAE-TLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQS------ 123

  Fly   258 ECDHVENVLQLSVHFT-------SAQFKKCSS--------IRIFRCKQLVYAWNNNTNRFQRING 307
              ...:...|.:|...       :||..|...        :|.:..:...|.|......|.:::.
Human   124 --QAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSL 186

  Fly   308 LDLNIPCSYYHQQR-GLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWF 371
            ||....|...|:.| ||.:.:|:.|:.::|.|.|::|::.:..||..|.|||:|.||.||:.||.
Human   187 LDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWL 251

  Fly   372 TYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDI 436
            ...||:||..|.|:|...|.:|:.:|:|....|:..|..:....|....|..:.:.:..:||||.
Human   252 ADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDC 316

  Fly   437 IEIPSSGCTLHCDAILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVI 501
            :.:|..|..:.|||.|::|.|:::||.|||||:||.||.||........:| |.||||||||.::
Human   317 LVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAET-HRRHTLFCGTLIL 380

  Fly   502 QTR-YIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLV 565
            |.| |:| ..|||.|..||..||||.|:.|||:|.|:::||.:.|.||:..|:::|.:|.||::.
Human   381 QARAYVG-PHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIF 444

  Fly   566 TKILRGTDPV-KIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINC 629
            . :.|...|: :|.:.:|||:|:||||||||||||...|||.||:...||||.|..||:.|.:..
Human   445 I-LYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQL 508

  Fly   630 CCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPL-KSVDRLPFDHFLFGMVTCHSITILNGRMMGDP 693
            .||||||||||||||:.||||..  .|..:|| ....|||....|..:.|||:::.|....:|||
Human   509 VCFDKTGTLTEDGLDVMGVVPLK--GQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDP 571

  Fly   694 LDLKMFESTGWELEDSNNIPDTEK-YGILYPTILRQP--RGGLSGMAETESGSKNEIKRQSSVDD 755
            :||||.|||||.||:.   |..:. :|.....::|.|  ...|..|.|
Human   572 MDLKMVESTGWVLEEE---PAADSAFGTQVLAVMRPPLWEPQLQAMEE----------------- 616

  Fly   756 LLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPD 820
              ..|.:|         ::..|||:|||||||||...........|.|||||::..||.|:::|.
Human   617 --PPVPVS---------VLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPT 670

  Fly   821 NYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVI 885
            :::|.|..:...|||::|:|.|.|....:....|:|:|:.||.::..||.:::.|.|||.||.||
Human   671 DFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVI 735

  Fly   886 NALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSS 950
            .||...:||.:|:||||:.||::|||.||:|:|.:.:|.|||
Human   736 QALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHA----------------------- 777

  Fly   951 DKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAE 1015
                         :...|.            .|.:.||        ..|||..          |.
Human   778 -------------THPERG------------QPASLEF--------LPMESPT----------AV 799

  Fly  1016 SGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLT 1080
            :|:...|..||. |::              ||...|.    .|:.|.|:.|:..:||:.:..:|.
Human   800 NGVKDPDQAASY-TVE--------------PDPRSRH----LALSGPTFGIIVKHFPKLLPKVLV 845

  Fly  1081 RGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNP 1145
            :|:::|||:|:||..||.|||.|.|||.|||||||||||||.|..|||||:.|||:.|||||...
Human   846 QGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMA 910

  Fly  1146 TISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAF 1210
            :|..|..||:|||.:|.|||.:|||||.|||.|||||:|||:|::||.|.|:|.:||.:.:..|.
Human   911 SIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAV 975

  Fly  1211 FFGKTESFDGMLVEQV-PLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFE--PADE 1272
            ...:|.  ..:::.:| |..:|:|...|:||||.:.:||..|:..:.....||||....  .|..
Human   976 LMSRTG--PALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAP 1038

  Fly  1273 DHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSN 1311
            |:|..:||..:|.:|||||:|||...|||||:|:||::|
Human  1039 DNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	30/153 (20%)
		P-type_ATPase_cation	326..1281	CDD:319842	374/963 (39%)
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	431/1170 (37%)