Protein Alignment anne and Atp13a3

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001121568.1
• Gene: Atp13a3 / 224088
• MGIID: 2685387
• Length: 1249
• Species: Mus musculus
• Alignment Length: 1343
• Identity: 502/1343 - (37%)
• Similarity: 732/1343 - (54%)
• Gaps: 211/1343 - (15%)

  Fly   154 LNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHW---WRHLYLYATCSQCSLEEAEQV 215
            :|..|||:|::.||.....:....:..:..|||.|.|:|:|   ||   :.|||.:.::::.|.|
Mouse     9 INKGQEDEMEIHGYNLCRWKLAMVFVGVICTGGFLLLLLYWLPEWR---VKATCVRAAVKDCEVV 70

  Fly   216 LV--TEDYQGKHKMYHVKQIQVLTSSNLKTL----LEKEQQSIERTHIECDHVENVLQLSVHFTS 274
            |:  |:::    :::...:|..|...|...|    |..|..:....|:.   .||..:::.:..|
Mouse    71 LLRTTDEF----RVWFCAKIHFLPVENQPNLNAKCLVNEVSNGHAVHLT---EENRCEMNKYSQS 128

  Fly   275 AQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCS--YYHQQRGLPVHEQISRRIVFGD 337
                :...:|.|....:.|.||:..:.|..:.|||..:.|:  |.....||.......|::::|.
Mouse   129 ----QSQQMRYFTHHSIRYFWNDAIHNFDFLKGLDEGVSCASLYEKHSAGLTQGMHAYRKLIYGV 189

  Fly   338 NEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQD 402
            |||.|.:.....||..|||||||:|||||||||...:|||||..|::|||..|..|:...:|...
Mouse   190 NEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSVDEYYYYALAIVIMSVVSIISSLYSIRKQYV 254

  Fly   403 VLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLT 465
            :|...|  ::|....|.......:|:.:..:||||::.||.:|..:.|||:||:|.||::|||||
Mouse   255 MLHDMVATHSTVRVSVCRENEEIEEIFSTDLVPGDVMIIPLNGTVMPCDAVLINGTCIVNESMLT 319

  Fly   466 GESVPVTKTPLPSKR-------DMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITA 523
            |||||||||.||:..       :..:....|.||||||||.|||||:...:.|.|.|:.||..|:
Mouse   320 GESVPVTKTNLPNPSVDVKGMGEEQYSPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTS 384

  Fly   524 KGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIV 588
            ||:|:||||||.|.|:|..:|:|.|:..|.::|.:|||||::..||...:..:|.::|||:|||.
Mouse   385 KGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVAGIGFIYTIINSILNEKEVQEIIIKSLDIITIT 449

  Fly   589 VPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSS 653
            ||||||||||.|..|||:|||...||||||:.||:.|.:|..||||||||||||||:||:....:
Mouse   450 VPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGIQRVEN 514

  Fly   654 TNQFQIPLKSV--DRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTE 716
            | :|.:|..:|  :.|....|:..|.||||:|.:.|.:.||||||||||:.||.||::.. .:|.
Mouse   515 T-RFLLPEDNVCSEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEEATE-EETA 577

  Fly   717 KYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTS 781
            .:..:.||::| |...|.....|....:.|:....::               ::.||||:|||:|
Mouse   578 LHNRIMPTVVR-PSKQLLPEPTTAGNQEMELFELPAI---------------YEIGIVRQFPFSS 626

  Fly   782 ALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSH 846
            ||||||||.|.|.::..:.|.||:||::..||||:::|.::.:.|.::.|:|:|:||:|.:.|..
Mouse   627 ALQRMSVVARTLGEKRMDAYMKGAPEVVASLCKPETVPVDFEKVLEDYTKQGFRVIALAHRKLES 691

  Fly   847 KMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVAR 911
            |:.:.|||.:||:.:||||:|:|.:|::|:||.:|..|:..|:.|.|||:|:||||:|||:||||
Mouse   692 KLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAVSVAR 756

  Fly   912 DCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCF 976
            |||::.|...||...|.|..|....:.|                .|||..|          ..|.
Mouse   757 DCGMILPQDKVIIAEALPPKDGKVAKIN----------------WHYTDSL----------SQCS 795

  Fly   977 NSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLP---TSDSLASVKTIDTWTHNDA 1038
            .|:..|.|                                .:|   ..|||           .|.
Mouse   796 ESSAIDSE--------------------------------AIPIKLAHDSL-----------EDL 817

  Fly  1039 ELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNL 1103
            |:...|            |||:||::.::.::|.:.:..|:..|:::|||:||||..||..|||:
Mouse   818 EVTRYH------------FAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLVEALQNV 870

  Fly  1104 DYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIF 1168
            ||.|.|||||||||||||.||.||||||.|||:||||||:.|:||.|..:|:||||||:|||.:|
Mouse   871 DYFVGMCGDGANDCGALKRAHGGISLSELEASVASPFTSKTPSISCVPNLIREGRAALMTSFCVF 935

  Fly  1169 KYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLIS 1233
            |:||.||::|:.||.:||||.|||.|.|:|::||.:|.:..|......::. .||.|.|.|.|||
Mouse   936 KFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIILVVVFTMSLNPAWK-ELVAQRPPSGLIS 999

  Fly  1234 STPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPAD---------------EDHL-------G 1276
            ...|.|:|..:.:...||...:.      |.|.::..|               ..||       .
Mouse  1000 GALLFSVLSQIVISVGFQSLGFF------WVKQYKVCDPNSDVCNTTRSACWNSSHLYNGTELDS 1058

  Fly  1277 C----FENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWVA 1337
            |    :||.|:|.||||||:.:|..||||.|:|:|.:.|:...::.|:....|::::|:|   ||
Mouse  1059 CKIQNYENTTVFFISSFQYLTVAVAFSKGKPFRQPCYKNYFFVISVIILYVFILFIMLHP---VA 1120

  Fly  1338 SFFQLI----VPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREK----------- 1387
            |..|::    ||  .::|..||.....:....|.||||.::.::: |....|:|
Mouse  1121 SVDQVLEIMCVP--YQWRIYMLIIVLINAFVSITVESFFLDTVLW-KVVFNRDKQGECRFSTTQP 1182

  Fly  1388 -------------NWV------TSKQKYMRLEHDISNIKNWPP 1411
                         :|.      |.|.|||.|..::.....|||
Mouse  1183 PQESVDRWGKCCLSWALSCRKKTPKAKYMYLAQELRFDPEWPP 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	35/146 (24%)
		P-type_ATPase_cation	326..1281	CDD:319842	407/994 (41%)
Atp13a3	NP_001121568.1	P-ATPase-V	14..1142	CDD:273738	482/1252 (38%)