DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and sca-1

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_499386.1	Gene:	sca-1 / 176512	WormBaseID:	WBGene00004736	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	1202	Identity:	246/1202 - (20%)
Similarity:	396/1202 - (32%)	Gaps:	417/1202 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 DLNIPCSYYHQ-QRGLPVHEQISRRIVFGDNEITVPLRDFKTL--LFLEVLNPFYV-FQLFSVIL 369
            |.|..|.::.. ..||...:..:.|..:|:||  :|..:.|:|  |.||..:...| ..|.:.|:
Worm     8 DANEVCKFFGTGPEGLTPQQVETLRNKYGENE--MPAEEGKSLWELILEQFDDLLVKILLLAAII 70

  Fly   370 WF-------------TYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQK-TVYNTGNAWVV--D 418
            .|             ....:....||||:.:...||.|.|.:..:..::. ..|....|.|:  .
Worm    71 SFVLALFEEHEDQTEAVTAFVEPFVILLILIANATVGVWQERNAESAIEALKEYEPEMAKVIRSG 135

  Fly   419 HKGL----SKELPTRAIVPGDIIEIPSSGCTLHCDAILI---SGNCILDESMLTGESVPVTK--T 474
            |.|:    :|||     ||||::|: |.|..:..|..|:   |....:|:|:||||||.|.|  .
Worm   136 HHGIQMVRAKEL-----VPGDLVEV-SVGDKIPADLRLVKIYSTTIRIDQSILTGESVSVIKHTD 194

  Fly   475 PLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKG----ELIRSILYPP 535
            .:|..|.:..||    ::.||.||.|      .|.|....|..||..|..|    |:..:.....
Worm   195 SVPDPRAVNQDK----KNCLFSGTNV------ASGKARGIVFGTGLTTEIGKIRTEMAETENEKT 249

  Fly   536 PVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPV-------------KIAVESLDLITI 587
            |:..|.::...:..:.:::| ||. ::.:  .|....||.             ||||.   |...
Worm   250 PLQQKLDEFGEQLSKVISVI-CVA-VWAI--NIGHFNDPAHGGSWVKGAIYYFKIAVA---LAVA 307

  Fly   588 VVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKS 652
            .:|..|||.:|.......:|:........|..|:...|..:..|.|||||||
Worm   308 AIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLT------------- 359

  Fly   653 STNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNI----- 712
             |||..:                     |...:.|:..||.::...|..:|...|....:
Worm   360 -TNQMSV---------------------SKMFIAGQASGDNINFTEFAISGSTYEPVGKVSTNGR 402

  Fly   713 ---PDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKR-QSSVDDLLAT-------------- 759
               |...::..|....:      :..|....|...||.|: ...|.:...|
Worm   403 EINPAAGEFESLTELAM------ICAMCNDSSVDYNETKKIYEKVGEATETALIVLAEKMNVFGT 461

  Fly   760 --VGISPSQKNFDHGIV---------REFPFTSALQRMSVVTRCL---SDQVFNVYCKGSPEMLK 810
              .|:||.:..   |:.         :||....:..|.|:...|.   ......::.||:||.:.
Worm   462 SKAGLSPKELG---GVCNRVIQQKWKKEFTLEFSRDRKSMSAYCFPASGGSGAKMFVKGAPEGVL 523

  Fly   811 KLC-----KPQSLP------DNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREE---- 860
            ..|     ..|.:|      .....|..::......:..:|...:...::   |..::.|:
Worm   524 GRCTHVRVNGQKVPLTSAMTQKIVDQCVQYGTGRDTLRCLALGTIDTPVS---VSNMNLEDSTQF 585

  Fly   861 --VENNMEFLGFVILENRLKPDTTKV---INALNAAKIRTIMITGDNILTAISVARDCGIVSPSQ 920
              .|.::.|:|.|   ..|.|..|:|   |.|.|.|.||.|||||||..||.::.|..|:
Worm   586 VKYEQDITFVGVV---GMLDPPRTEVSDSIKACNHAGIRVIMITGDNKNTAEAIGRRIGL----- 642

  Fly   921 SVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPET 985
                     .|:
Worm   643 ---------FGE----------------------------------------------------- 645

  Fly   986 PEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESW 1050
                                 ||.|:..|.:|          :..|
Worm   646 ---------------------NEDTTGKAYTG----------REFD------------------- 660

  Fly  1051 RRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGAN 1115
                              |..||:......|..::||:.|..|..:|..||:.....||.|||.|
Worm   661 ------------------DLPPEQQSEACRRAKLFARVEPSHKSKIVDILQSQGEITAMTGDGVN 707

  Fly  1116 DCGALKVAHAGISLSE--TEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQ 1178
            |..|||.|..|||:..  ..|..||.....:...::::..::||||.........:|:.:.::.:
Worm   708 DAPALKKAEIGISMGSGTAVAKSASEMVLADDNFASIVSAVEEGRAIYNNMKQFIRYLISSNVGE 772

  Fly  1179 FISVMIL--YSIDSNLTDKQYLYVDL-----------------------------GLISIFAFF- 1211
            .:|:.::  ..|...|...|.|:|:|                             ||||.:.||
Worm   773 VVSIFMVAALGIPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRHPRSANDGLISGWLFFR 837

  Fly  1212 FGKTESFDG-----------MLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFK 1265
            :....::.|           :|.|:.|                  .:|.:|:|.|:...
Worm   838 YLAVGTYVGVATVGASMWWFLLYEEGP------------------QITYYQLTHWMRCE------ 878

  Fly  1266 AFEPADEDHLGC--FEN-----------------YTMFCISSFQYIILAFVFSKGAPYRKPLWSN 1311
             .||.:...|.|  ||:                 ..:..:|..|.:::           .|.|.|
Worm   879 -IEPDNFADLDCAVFEDNHPNAMALSVLVTIEMLNAINSLSENQSLLV-----------MPPWKN 931

  Fly  1312 -WPLCLAFIVNLCIIVYLVLYPSDWVASFFQL 1342
             |   |...::|.:.::.|:...|.:|:.||:
Worm   932 IW---LMAAISLSMSLHFVILYVDIMATIFQI 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	246/1202 (20%)
		E1-E2_ATPase	381..621	CDD:278548	73/268 (27%)
		Cation_ATPase	<758..813	CDD:289987	14/82 (17%)
		HAD_like	<1087..1137	CDD:304363	21/51 (41%)
sca-1	NP_499386.1	Cation_ATPase_N	4..71	CDD:279080	18/64 (28%)
		ATPase-IIA1_Ca	52..990	CDD:273452	233/1156 (20%)
		E1-E2_ATPase	95..342	CDD:278548	74/269 (28%)
		Cation_ATPase	423..529	CDD:289987	21/108 (19%)
		HAD	<607..713	CDD:289480	44/240 (18%)
		Cation_ATPase_C	785..988	CDD:279079	38/215 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910