Protein Alignment anne and Atp12a

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_598201.2
• Gene: Atp12a / 171028
• RGDID: 620569
• Length: 1036
• Species: Rattus norvegicus
• Alignment Length: 1144
• Identity: 238/1144 - (20%)
• Similarity: 401/1144 - (35%)
• Gaps: 363/1144 - (31%)

  Fly   336 GDNEITVPLRDFKTLLFLEVLNPFYVFQL---FSVILW---------FTYDY----------YYY 378
            |.|.:|.|.:..:.:.||:        |:   ||::||         |...|          |..
  Rat    89 GPNTLTPPKQTPEIIKFLK--------QMVGGFSILLWIGAALCWIAFVIQYVNNSASLDNVYLG 145

  Fly   379 ACVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSG 443
            |.::|::.:.|| .:..|..|:.:::...........:|......|.:....:|.||::|| ..|
  Rat   146 AILVLVVILTGI-FAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVGDVVEI-KGG 208

  Fly   444 CTLHCDAILI-SGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIG 507
            ..:..|..|: |..|.:|.|.|||||.|                  .||.|.|.....::|:.||
  Rat   209 DQIPADIRLVFSQGCKVDNSSLTGESEP------------------QARSTEFTHENPLETKNIG 255

  Fly   508 -------SKKVLAFVINTGNITAKGELIRSIL-----YPPPVDYKFEQDSYKFIQFLAIIA-CVG 559
                   .......|||||:.|..|. |.|:.     ...|:..:.|.    |:..:|.:| .:|
  Rat   256 FYSTTCLEGTATGIVINTGDRTIIGR-IASLASGVGSEKTPIAIEIEH----FVHIVAGVAVSIG 315

  Fly   560 FIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVA 624
            .|: .:|.:......:...:..:.:|...||..|.|.:||......||:........:..::...
  Rat   316 IIF-FITAVCMKYYVLDAIIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETL 379

  Fly   625 GSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRM 689
            ||.:..|.|||||||::.:                   :|..|.||:.:|...|..:.|    :.
  Rat   380 GSTSIICSDKTGTLTQNRM-------------------TVAHLWFDNQIFVADTSENQT----KQ 421

  Fly   690 MGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKN-EIKRQSSV 753
            ..|       :|:|.....|..|.                   |...||...|.:: .|.:::.|
  Rat   422 AFD-------QSSGTWASLSKIIT-------------------LCNRAEFRPGQESVPIMKRTVV 460

  Fly   754 DDLLATVGISPSQ---------KNFDHGIVREFPFTSALQ-RMSV-VTRCLSDQVFNVYCKGSPE 807
            .|...|..:..|:         :..:|. |.|.||.|..: ::|: .|...:|:.|.|..||:||
  Rat   461 GDASETALLKFSEVILGDVMGIRKRNHK-VAEIPFNSTNKFQLSIHETEDPNDKRFLVVMKGAPE 524

  Fly   808 MLKKLCK-----------PQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEV 861
            .:.:.|.           .:|..|::.....|....|.|::.....       |...::..:..:
  Rat   525 RILEKCSTIMINGQEQPLDKSSADSFHTAYMELGGLGERVLGFCHL-------YLPAEQFPQSYI 582

  Fly   862 ---------ENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVS 917
                     .:|..|:|.:.:.:..:......::...:|.|:.||:|||:.:||.::|:..||:|
  Rat   583 FDVDSVNFPTSNFCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIIS 647

  Fly   918 PSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFD 982
            .:...:    :.|....||...
  Rat   648 ANNETV----EDIAKRRNIAVE------------------------------------------- 665

  Fly   983 PETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPD 1047
                    ||.|                          .::.|:|.|           |::
  Rat   666 --------QVNK--------------------------REAKAAVVT-----------GME---- 681

  Fly  1048 ESWRRQECIFAMDGKTWQIVKDYFPEEMEILLT--RGSIYARMSPDQKQALVIELQNLDYCVAMC 1110
                               :||..||:::.|||  :..::||.||.||..:|...|..|..||:.
  Rat   682 -------------------LKDMTPEQLDELLTNYQEIVFARTSPQQKLIIVEGCQRQDAIVAVT 727

  Fly  1111 GDGANDCGALKVAHAGISL---SETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMA 1172
            |||.||..|||.|..||::   ....|..|:.....:...::::..::|||..    |...|...
  Rat   728 GDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLI----FDNLKKTI 788

  Fly  1173 AYSLVQFIS------VMILYSIDSNLTDKQYLYVDLG--LISIFAFFFGKTES-----------F 1218
            ||:|.:.|:      :.|:..:...:.....|::|||  :|...|..:.|.||           .
  Rat   789 AYTLTKNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKK 853

  Fly  1219 DGMLVEQVPLSSLIS---STPLASLLLHLTVVT--AFQVTCWVHLHQQPWFKAFEPAD----EDH 1274
            |.::..|:.:.|.:.   ...|...|::.||..  .|..|..::|.     .|:|..|    ||.
  Rat   854 DRLVNTQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLR-----VAWETDDINDLEDS 913

  Fly  1275 LGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCI--IVYLVLYPSD--- 1334
            .|  :.:|.:                   .||.|  .|....||.|.:.|  |..|::..:.
  Rat   914 YG--QEWTRY-------------------QRKYL--EWTGSTAFFVAIMIQQIADLIIRKTRRNS 955

  Fly  1335 ------------WVASFFQLIVPPTMRFRYVMLAYGAAS 1361
                        ||....|:||.       ::|:||..|
  Rat   956 IFQQGLFRNKVIWVGIASQVIVA-------LILSYGLGS 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	218/1045 (21%)
Atp12a	NP_598201.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		ATPase-IIC_X-K	40..1036	CDD:273445	238/1144 (21%)