Protein Alignment anne and Atp13a1

DIOPT Version :9

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_006509627.1
• Gene: Atp13a1 / 170759
• MGIID: 2180801
• Length: 1223
• Species: Mus musculus
• Alignment Length: 1315
• Identity: 331/1315 - (25%)
• Similarity: 512/1315 - (38%)
• Gaps: 380/1315 - (28%)

  Fly   177 CW-----------------ACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLVTEDYQGK 224
            ||                 |.|.|...|..|..||..|.:...||             |.:|. .
Mouse    83 CWGWGSSWTQIPEAALLALATICLAHALTVLSGHWSVHAHCALTC-------------TPEYD-P 133

  Fly   225 HKMYHVKQIQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRCK 289
            :|:..||.:.  |.:|         .|.|...:..|..|:.|::    .|.:|:|
Mouse   134 NKVTFVKVVP--TPNN---------GSTELVALHRDKGEDGLEV----LSFEFQK---------- 173

  Fly   290 QLVYAWNNNTNRFQRINGLDLNIPC----SYYHQQRGLPVHEQI-SRRIVFGDNEITVPLRDFKT 349
             :.|::    :..::...|.:..|.    |||...||.....:| :....||.|:..:.:.||..
Mouse   174 -IKYSY----DALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFSE 233

  Fly   350 LLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQK-------- 406
            |.......||:|||:|.|.||...:|:||:...|.|.|......|.|..:|...::|
Mouse   234 LFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHMI 298

  Fly   407 TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEI---PSSGCTLHCDAILISGNCILDESMLTGES 468
            .||.: ..|        :.:.:..||||||:.|   |... .:.||.:|:.|.||:||:||||||
Mouse   299 QVYRS-RKW--------RPVASDDIVPGDIVSIGRSPQEN-LVPCDVLLLRGRCIVDEAMLTGES 353

  Fly   469 VPVTKTPLPS-KRDMIFDKTEHAR-HTLFCGTKVIQTRYIGSKKV-----------LAFVINTGN 520
            ||..|.|:.. ..|.:.|....|| |.:|.||||:|  :|..:|.           :|||:.||.
Mouse   354 VPQMKEPIEDLSPDRVLDLQADARLHVIFGGTKVVQ--HIPPQKATSGLKPVDNGCVAFVLRTGF 416

  Fly   521 ITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGT-DP----VKIAVE 580
            .|::|.|:|:||:..........:::.||.||.:.|.....|..|    .|| ||    .|:.:|
Mouse   417 NTSQGRLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWV----EGTKDPSRNRYKLFLE 477

  Fly   581 SLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDM 645
            ...::|.||||.||..:::....:...|....::|..|..|..||.:..||||||||||.|.|.:
Mouse   478 CTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVV 542

  Fly   646 WGVV----PKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITIL-NGRMMGDPLDLKMFESTGWE 705
            .||.    .|..|....||:::...|         .:|||:..| :|.::||||:..|..:..|.
Mouse   543 RGVAGLRDGKEVTPVSSIPIETHRAL---------ASCHSLMQLDDGTLVGDPLEKAMLTAVDWT 598

  Fly   706 LEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFD 770
            |.....:         :|..::                               |.|:...|:
Mouse   599 LTKDEKV---------FPRSIK-------------------------------TQGLKIHQR--- 620

  Fly   771 HGIVREFPFTSALQRMSVVTRC----LSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAK 831
                  |.|.|||:||||:...    .:|..:....||:||.|..:.  ...|.:|....:|.::
Mouse   621 ------FHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMF--SQCPPDYHHIHTEISR 677

  Fly   832 KGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTI 896
            :|.|::|:.:|.|.| :.:.:.:.:.||.:|.:::|:||:::...||.|:..||..:..|..|.:
Mouse   678 EGARVLALGYKELGH-LTHQQAREIKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVV 741

  Fly   897 MITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLD 961
            ||||||.|||..||::...:..:.::| :|.         .:..|..|.: .|.|....|  .|.
Mouse   742 MITGDNPLTACHVAQELHFIDKAHTLI-LHP---------PSEKGQPCEW-RSIDSSIVL--PLT 793

  Fly   962 LGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLAS 1026
            |||..:.|.....|.                                           |.|.||.
Mouse   794 LGSPKALALEHALCL-------------------------------------------TGDGLAH 815

  Fly  1027 VKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPD 1091
            ::.:|                                        |:::..|:....::||::|.
Mouse   816 LQAVD----------------------------------------PQQLLCLIPHVQVFARVAPK 840

  Fly  1092 QKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSET------------------------ 1132
            ||:.::..|:.|.|...|||||.||.||||.|..|::|...
Mouse   841 QKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPVLSNSGPR 905

  Fly  1133 -------------------------------------------EASIASPFTSRNPTISAVLKVI 1154
                                                       :||||:||||:..:|..:..||
Mouse   906 VSRSTKQKSALLSPEEPPASHRDRLSQVLRDLEEESTPIVKLGDASIAAPFTSKLSSIQCICHVI 970

  Fly  1155 KEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFD 1219
            |:||..|||:..:||.:|..:|:...|..:||......:|.|.....|.|...|.|
Mouse   971 KQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLF--------- 1026

  Fly  1220 GMLVEQVPLSSLISSTPLA---SLLLHLTVVTAFQV--TCWVHLHQQ-------------PWFKA 1266
              :....||.:|....||.   :|...|||:..|.|  ...|:|:::             ..:|.
Mouse  1027 --ISRSKPLKTLSRERPLPNIFNLYTILTVMLQFSVHFLSLVYLYREAQARSPEKQEQFVDLYKE 1089

  Fly  1267 FEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLY 1331
            |||:       ..|.|::.::....:....:..||.|:.:.|..|.||..:..|:|..|:.|:|.
Mouse  1090 FEPS-------LVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLAVSLLAIIGLLLG 1147

  Fly  1332 PSDWVASFFQLIVPP 1346
            .|....|.|.|:..|
Mouse  1148 SSPDFNSQFGLVDIP 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	27/130 (21%)
		P-ATPase-V	173..1355	CDD:273738	331/1315 (25%)
		E1-E2_ATPase	381..621	CDD:278548	83/268 (31%)
		Cation_ATPase	<758..813	CDD:289987	18/58 (31%)
		HAD_like	<1087..1137	CDD:304363	23/116 (20%)
Atp13a1	XP_006509627.1	P-type_ATPase_cation	211..1130	CDD:319843	284/1109 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930