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Protein Alignment anne and Atp7a

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001103227.1	Gene:	Atp7a / 11977	MGIID:	99400	Length:	1492	Species:	Mus musculus

Alignment Length:	1240	Identity:	229/1240 - (18%)
Similarity:	427/1240 - (34%)	Gaps:	392/1240 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PVDMHYVATESVQPK-KSDKVPSNKIKKVENNNTLV-NGC-----SKTSARSVPLLKYNRPDQDG 118
            |.||........||. ::..:||:  .::||..|.| |.|     ..|.|..|..::.|.
Mouse   445 PADMKEPLVVIAQPSLETPLLPSS--NELENVMTSVQNKCYIQVSGMTCASCVANIERNL----- 502

  Fly   119 DSEENITSVLEPNVDEIYSKDSERLVDDSKPCIGLLNPDQEDQMKVCGYRRSLMRTGFCWACIFL 183
            ..||.|.|||   |..:..|...|           .||.......:..:.|.|   ||....:..
Mouse   503 RREEGIYSVL---VALMAGKAEVR-----------YNPAVIQPRVIAEFIREL---GFGAMVMEN 550

  Fly   184 TG---GLLRLVLHWWRHLYLYATCSQCSLEEAEQVLVTEDYQGKHK--MY----------HVKQ- 232
            .|   |:|.||:..       .||:.| :.:.|..|.      |||  .|          |:|.
Mouse   551 AGEGNGILELVVRG-------MTCASC-VHKIESTLT------KHKGIFYCSVALATNKAHIKYD 601

  Fly   233 ---------IQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRC 288
                     |..:.|...:..|.|:.:|  ..|:  ||...:.|....|.         :.:|.|
Mouse   602 PEIIGPRDIIHTIGSLGFEASLVKKDRS--ANHL--DHKREIKQWRGSFL---------VSLFFC 653

  Fly   289 ----KQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDFKT 349
                ..:||           :..:|.::...:::|..               .||..:   :..:
Mouse   654 IPVMGLMVY-----------MMVMDHHLATLHHNQNM---------------SNEEMI---NMHS 689

  Fly   350 LLFLE--VLNPFYVFQLFSVIL---------WFTYDYYY-----------------------YAC 380
            .:|||  :|....:..|.|::|         |:.|...|                       |:.
Mouse   690 AMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSL 754

  Fly   381 VILLMSVF-----------------------GITVSVLQTKKNQDVLQKTV-YNTGNAWVV---- 417
            ||||:::|                       |..:..:...|..:.|.|.: .....|.:|
Mouse   755 VILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNS 819

  Fly   418 DHKGLSKE-LPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLTGESVPVTKTPLPSKRD 481
            ::..||:| :....:..||||::...| ....|..:|.|:.::|||::|||::||.|.|
Mouse   820 ENLLLSEEQVDVELVQRGDIIKVVPGG-KFPVDGRVIEGHSMVDESLITGEAMPVAKKP------ 877

  Fly   482 MIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSY 546
               ..|..|......|:.:|:..::|:...|:.::   .:..:.:..::     |:....::.|.
Mouse   878 ---GSTVIAGSINQNGSLLIRATHVGADTTLSQIV---KLVEEAQTSKA-----PIQQFADKLSG 931

  Fly   547 KFIQFLAIIACVGFIYTLV-----------------TKILRGTDPVKIAVE-SLDLITIVVPPAL 593
            .|:.|:.:::.|..:..::                 ..|.|....::.|.: |:.::.|..|.:|
Mouse   932 YFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSL 996

  Fly   594 ----PAAMTVGRFYAQKR---LKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPK 651
                |.|:.||.....:.   :|..|       .:.:|..:....||||||:|. |..:
Mouse   997 GLATPTAVMVGTGVGAQNGILIKGGE-------PLEMAHKVKVVVFDKTGTITH-GTPV------ 1047

  Fly   652 SSTNQFQIPLKS--VDRLPF-----------DHFLFGMVTCHSITILNGRMMGDPLDLKMFESTG 703
              .||.::.::|  :.|...           :|.|...||.:....|:...:|...|.::....|
Mouse  1048 --VNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCKKELDTETLGTCTDFQVVPGCG 1110

  Fly   704 WELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKN 768
            ...:.:|      ..|:|:.:.|:.....:...:..:..:.||   |||.
Mouse  1111 ISCKVTN------IEGLLHKSNLKIEENNIKNASLVQIDAINE---QSST--------------- 1151

  Fly   769 FDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKG 833
                       :|::...:.::..::.|.:.|.......|::   ....:.::..:.:.|..::|
Mouse  1152 -----------SSSMIIDAHLSNAVNTQQYKVLIGNREWMIR---NGLVISNDVDESMIEHERRG 1202

  Fly   834 YRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMI 898
            ...:.:..                      :.|..|.:.:.:.:||:....::.|.:..:..:::
Mouse  1203 RTAVLVTI----------------------DDELCGLIAIADTVKPEAELAVHILKSMGLEVVLM 1245

  Fly   899 TGDNILTAISVARDCGI------VSPSQSV------------ITVHADPIGDS-----AN--IQT 938
            ||||..||.|:|...||      |.||..|            :.:..|.|.||     ||  |..
Mouse  1246 TGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAI 1310

  Fly   939 NTGTECNFDNSS-----DKHYKLHYTLDLGSKTSRA----YLFKSCFN-------SNLFDPETPE 987
            .|||:...:.:.     :....:..::||..||.:.    ::|...:|       :.:|.|
Mouse  1311 GTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFLP---- 1371

  Fly   988 FTAQVGKTIFHMESTNSLVNESTSSYAES------GLPTSDSLASVKTIDTWTHNDAELGIKHTP 1046
                :|..:.....:.::...|.|....|      ..||.|:........|...:.:|:.:....
Mouse  1372 ----IGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYDNYELHPRSHTGQRSPSEISVHVGI 1432

  Fly  1047 DESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMS------------PDQKQALVIE 1099
            |::.|....:..:|    :||.          .:|.||.:.:|            ||:...||.:
Mouse  1433 DDTSRNSPRLGLLD----RIVN----------YSRASINSLLSDKRSLNSVVTSEPDKHSLLVGD 1483

  Fly  1100 LQNLD 1104
            .:..|
Mouse  1484 FREDD 1488

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.