DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp4a

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001277556.1	Gene:	Atp4a / 11944	MGIID:	88113	Length:	1034	Species:	Mus musculus

Alignment Length:	1159	Identity:	235/1159 - (20%)
Similarity:	404/1159 - (34%)	Gaps:	357/1159 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 RGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLM 385
            ||.|.:.:.:|::..|          .:.|:::........|.:.:.....|.|...|..|.|:.
Mouse    94 RGTPEYVKFARQLAGG----------LQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAVALIA 148

  Fly   386 SV-----FGI-----TVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIP 440
            .|     ||.     :.:::.:.||....|.||...|:.:         ::....:|.||::|:
Mouse   149 VVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKF---------QINADQLVVGDLVEM- 203

  Fly   441 SSGCTLHCD-AILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTR 504
            ..|..:..| .||.:..|.:|.|.|||||.|.|::|     :...:.....|:..|..|..::
Mouse   204 KGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSP-----ECTHESPLETRNIAFFSTMCLE-- 261

  Fly   505 YIGSKKVLAFVINTGNITAKGELIRSIL-----YPPPVDYKFEQDSYKFIQFLAIIA-------- 556
              |:.:.|  |::||:.|..|. |.|:.     ...|:..:.|.    |:..:|.:|
Mouse   262 --GTAQGL--VVSTGDRTIIGR-IASLASGVENEKTPIAIEIEH----FVDIIAGLAILFGATFF 317

  Fly   557 ----CVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCIS 617
                |:|:.:            ::..|..:.::...||..|.|.:||......|||.:......:
Mouse   318 VVAMCIGYTF------------LRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKN 370

  Fly   618 PRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSI 682
            ..::...||.:..|.|||||||::.:                   :|..|.||:.:....|..
Mouse   371 LEAVETLGSTSVICSDKTGTLTQNRM-------------------TVSHLWFDNHIHTADTTE-- 414

  Fly   683 TILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKN-E 746
                             :.:|...:.|     :|.:..|...:.      |...|..:||... .
Mouse   415 -----------------DQSGQTFDQS-----SETWRALCRVLT------LCNRAAFKSGQDAVP 451

  Fly   747 IKRQSSVDDLLATVGISPSQKNFDHGI--------VREFPFTSALQRMSVVTRCLSDQVFN---V 800
            :.::..:.|...|..:..|:....:.:        |.|.||.| :.:..:....|.|...:   :
Mouse   452 VPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNS-INKFQLSIHTLEDPRDSRHLL 515

  Fly   801 YCKGSPEMLKKLC-----KPQSLPDNYSQQLSEFAKKGY--------RIIAIAFKALSHKMNYTK 852
            ..||:||.:.:.|     |.|.||  ..:|..|..:..|        |::......|:.| :|..
Mouse   516 VMKGAPERVLERCSSILIKGQELP--LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEK-DYPP 577

  Fly   853 VQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCG 914
            ......|.:......|.|..|.:.:.|....|.:|:   ..|.||.||:|||:.:||.::|...|
Mouse   578 GYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVG 642

  Fly   915 IVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSN 979
            |:|.                                            ||:|
Mouse   643 IISE--------------------------------------------GSET------------- 650

  Fly   980 LFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVK-TIDTWTHNDAELGIK 1043
                                                    ..|..|.:: .:|.....||
Mouse   651 ----------------------------------------VEDIAARLRMPVDQVNRKDA----- 670

  Fly  1044 HTPDESWRRQECIFAMDGKTWQIVKDYFPEEM-EILLTRGS-IYARMSPDQKQALVIELQNLDYC 1106
                     :.|:  ::|..   :||..|.|: |.|.|... ::||.||.||..:|...|.|...
Mouse   671 ---------RACV--INGMQ---LKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAI 721

  Fly  1107 VAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTS------- 1164
            ||:.|||.||..|||.|..|:::     .||....::|   :|.:.::.:..|::||.
Mouse   722 VAVTGDGVNDSPALKKADIGVAM-----GIAGSDAAKN---AADMILLDDNFASIVTGVEQGRLI 778

  Fly  1165 FGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVD----LGLISIF------------AFFFG 1213
            |...|...||:|.:.|..:..|.|        |:.|.    ||.|:|.            :..:.
Mouse   779 FDNLKKSIAYTLTKNIPELTPYLI--------YITVSVPLPLGCITILFIELCTDIFPSVSLAYE 835

  Fly  1214 KTESFDGMLVEQVPLSSLISSTPLASL-LLHLTVVTAFQ--VTCWVHLHQQPWFK----AFEPAD 1271
            |.||....|..:.|....:.:.|||:. ...:..:.:|.  ...:..:.|:.||.    ...|..
Mouse   836 KAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQW 900

  Fly  1272 EDH----------------------LGCFENYTMFCISSFQYIILAFVFSKG---APYRKPLWSN 1311
            |||                      ..|   ||:|.||.....|...:..|.   :.:::..:.|
Mouse   901 EDHHLQDLQDSYGQEWTFGQRLYQQYTC---YTVFFISIEMCQIADVLIRKTRRLSVFQQGFFRN 962

  Fly  1312 WPLCLAFIVNLCIIVYLVLYPSDWVASFFQLIVPPTMRFRY--VMLAYGAASFI 1363
            ..|.:|.:..:||..:|...|.  :.:.|..:   .:||::  |.:.:|...|:
Mouse   963 KILVIAIVFQVCIGCFLCYCPG--MPNIFNFM---PIRFQWWLVPMPFGLLIFV 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	233/1149 (20%)
		E1-E2_ATPase	381..621	CDD:278548	59/267 (22%)
		Cation_ATPase	<758..813	CDD:289987	13/65 (20%)
		HAD_like	<1087..1137	CDD:304363	20/49 (41%)
Atp4a	NP_001277556.1	H-K_ATPase_N	2..>27	CDD:286172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..40
		ATPase-IIC_X-K	42..1034	CDD:273445	235/1159 (20%)
		Cation_ATPase_N	50..124	CDD:214842	6/39 (15%)
		E1-E2_ATPase	156..375	CDD:278548	56/256 (22%)
		Cation_ATPase	437..531	CDD:289987	19/94 (20%)
		COG4087	616..>742	CDD:226572	51/241 (21%)
		Cation_ATPase_C	809..1018	CDD:279079	41/211 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930