DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp2a2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001103610.1	Gene:	Atp2a2 / 11938	MGIID:	88110	Length:	1044	Species:	Mus musculus

Alignment Length:	1145	Identity:	248/1145 - (21%)
Similarity:	398/1145 - (34%)	Gaps:	346/1145 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HQQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFS---------------V 367
            ::..||.:.:....:..:|.||:  |..:.||||.|       |.:.|.               |
Mouse    19 NESTGLSLEQVKKLKERWGSNEL--PAEEGKTLLEL-------VIEQFEDLLVRILLLAACISFV 74

  Fly   368 ILWF-----TYDYYYYACVILLMSVFGITVSVLQTKKNQ---DVLQKTVYNTGNAWVVDHKGLSK 424
            :.||     |...:....||||:.|....|.|.|.:..:   :.|::.....|..:..|.|.:.:
Mouse    75 LAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQR 139

  Fly   425 ELPTRAIVPGDIIEIPSSGCTLHCDAILI---SGNCILDESMLTGESVPVTK--TPLPSKRDMIF 484
             :..:.||||||:|| :.|..:..|..|.   |....:|:|:||||||.|.|  .|:|..|.:..
Mouse   140 -IKAKDIVPGDIVEI-AVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQ 202

  Fly   485 DKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKG----ELIRSILYPPPVDYKFEQDS 545
            ||    ::.||.||.      |.:.|.:..|:.||..|..|    |::.:.....|:..|.::..
Mouse   203 DK----KNMLFSGTN------IAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFG 257

  Fly   546 YKFIQFLAIIACVGFIYTLVTKILRGTDPV-------------KIAVESLDLITIVVPPALPAAM 597
            .:..:.:::| |:.   ..:..|....|||             ||||.   |....:|..|||.:
Mouse   258 EQLSKVISLI-CIA---VWIINIGHFNDPVHGGSWIRGAIYYFKIAVA---LAVAAIPEGLPAVI 315

  Fly   598 TVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDM--WGVVPK-----SSTN 655
            |.......:|:........|..|:...|..:..|.|||||||.:.:.:  ..::.|     .|.|
Mouse   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLN 380

  Fly   656 QFQI------PLKSV--DRLPFD-HFLFGMVTCHSITILNGRMMGDPLDLK-MFESTGWELE--- 707
            :|.|      |:..|  |..|.. |...|:|...:|..|......|..:.| ::|..|...|
Mouse   381 EFSITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETAL 445

  Fly   708 ----DSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKN 768
                :..|:.|||..|:                        ::|:|.::.:.::..:
Mouse   446 TCLVEKMNVFDTELKGL------------------------SKIERANACNSVIKQL-------- 478

  Fly   769 FDHGIVREFPFTSALQRMSVVTRCLSDQ-----VFNVYCKGSPEMLKKLC--------KPQSLPD 820
                :.:||....:..|.|:...|..::     :..::.||:||.:...|        |....|.
Mouse   479 ----MKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPG 539

  Fly   821 NYSQQLSEFAKKG-----YRIIAIAFKALSHKMNYTKVQRLSREEV-----------ENNMEFLG 869
            ...:.:|...:.|     .|.:|:|          |....|.|||:           |.|:.|:|
Mouse   540 VKQKIMSVIREWGSGSDTLRCLALA----------THDNPLKREEMHLEDSANFIKYETNLTFVG 594

  Fly   870 FVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSA 934
            .|.:.:..:.:....:.....|.||.|||||||..||:::.|..||....:.|
Mouse   595 CVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDV------------ 647

  Fly   935 NIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHM 999
                                           ||:|      |....||..:|
Mouse   648 -------------------------------TSKA------FTGREFDELSP------------- 662

  Fly  1000 ESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTW 1064
                                                             |.:|..|:.|
Mouse   663 -------------------------------------------------SAQRDACLNA------ 672

  Fly  1065 QIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISL 1129
                              ..:||:.|..|..:|..||:.|...||.|||.||..|||.:..||::
Mouse   673 ------------------RCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAM 719

  Fly  1130 SE--TEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSI--DS 1190
            ..  ..|..||.....:...|.::..::||||.........:|:.:.::.:.:.:.:..::  ..
Mouse   720 GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPE 784

  Fly  1191 NLTDKQYLYVDLGLISIFAFFFG-KTESFDGM-LVEQVPLSSLISSTPLASLL---LHLTVVTAF 1250
            .|...|.|:|:|....:.|...| .....|.| ...:.|...|||.......|   .::...|..
Mouse   785 ALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVG 849

  Fly  1251 QVTCW---------VHLHQQPWF---KAFEPADEDHLGC--FEN-YTMFCISSFQYII-----LA 1295
            ....|         |..:|...|   |...| |.|.:.|  ||: |.|....|....|     |.
Mouse   850 AAAWWFIAADGGPRVSFYQLSHFLQCKEDNP-DFDGVDCAIFESPYPMTMALSVLVTIEMCNALN 913

  Fly  1296 FVFSKGAPYRKPLWSN-W---PLCLAFIVNLCIIVYLVLY 1331
            .:....:..|.|.|.| |   .:||:..::     :|:||
Mouse   914 SLSENQSLLRMPPWENIWLVGSICLSMSLH-----FLILY 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	248/1145 (22%)
		E1-E2_ATPase	381..621	CDD:278548	71/264 (27%)
		Cation_ATPase	<758..813	CDD:289987	9/59 (15%)
		HAD_like	<1087..1137	CDD:304363	20/51 (39%)
Atp2a2	NP_001103610.1	Cation_ATPase_N	4..72	CDD:279080	13/61 (21%)
		ATPase-IIA1_Ca	53..988	CDD:273452	237/1102 (22%)
		E1-E2_ATPase	93..340	CDD:278548	72/265 (27%)
		Cation_ATPase	419..527	CDD:289987	23/143 (16%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		3/18 (17%)
		HAD	<605..711	CDD:289480	43/240 (18%)
		Cation_ATPase_C	783..986	CDD:279079	41/172 (24%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		5/19 (26%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000269\|PubMed:23395171	788..1044		40/167 (24%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930