Protein Alignment anne and atp13a2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_031761296.1
• Gene: atp13a2 / 116412065
• XenbaseID: XB-GENE-996840
• Length: 1179
• Species: Xenopus tropicalis
• Alignment Length: 1315
• Identity: 478/1315 - (36%)
• Similarity: 701/1315 - (53%)
• Gaps: 183/1315 - (13%)

  Fly   139 DSERLVDDSKP-CIGLLNP-DQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLY 201
            |:.||:...|| ..|.|.| :....|::.||||...:...|.....||.|:|.|..||...||:.
 Frog     4 DNSRLLGPQKPGGYGTLPPCEFRSCMEIRGYRRITWKLVLCCILCVLTLGVLLLFFHWKPRLYVL 68

  Fly   202 ATCSQCSLEEAEQVLVTEDYQGKHKMYHVKQIQVLTSS-------------NLKTLLEKEQQSIE 253
            .||..|.|.||..:::.::: |:..:..|:..|.:..|             ....::..|.|...
 Frog    69 LTCRHCPLAEANWLVIKDEF-GQISIAEVRVEQGMDVSLGPYMTGRLGINGGGSVIIGVEDQEDF 132

  Fly   254 RTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYH 318
            :..|:..|.|               :.:::|.|..:.:.|.|:|.|..|.|::.||..:.|...|
 Frog   133 KDTIQLHHKE---------------ENNALRYFVFEGMRYVWSNRTQNFVRVSSLDEGVTCGELH 182

  Fly   319 QQR-GLPVHEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVI 382
            ::: ||...|..:|:.:||.|||.||::.:..||..|||||||:||:||::||...:||||:..|
 Frog   183 KKKFGLNQTEHNTRKQIFGANEIDVPVKSYGRLLIEEVLNPFYIFQVFSIVLWMCDNYYYYSACI 247

  Fly   383 LLMSVFGITVSVLQTKKNQDVLQKTV---------YNTGNAWVVDHKGLSKELPTRAIVPGDIIE 438
            |::|:..|::|:.:|:|....|:..|         .:||...:|:...|         ||||.|.
 Frog   248 LVISIISISLSLYETRKQSVTLRNMVKMQVSVKVRRDTGEEMLVNSPDL---------VPGDCII 303

  Fly   439 IPSSGCTLHCDAILISGNCILDESMLTGESVPVTKTPL---PSKRDMIFDKTEHARHTLFCGTKV 500
            :|..|..:.|||.|::|.|:::||||||||||..||||   |......:...||.|||||.||::
 Frog   304 LPPEGILMPCDAALLTGECMVNESMLTGESVPEMKTPLTDGPQAGRTPYCPEEHKRHTLFGGTQI 368

  Fly   501 IQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLV 565
            ||.:....|:|:|.|..||..|.||.||.|||:|.||.:||.:|:.||:..|.:.|.:|.:||:.
 Frog   369 IQAKSYLEKEVIAVVTRTGFCTVKGNLISSILHPKPVSFKFYRDAVKFVLVLGLFAFLGNVYTIG 433

  Fly   566 TKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCC 630
            ..|...:...:|.:::||||||:||||||||||||..|||.|||...||||||..|||.|.|...
 Frog   434 ILIRNKSTVSRIVIQTLDLITIIVPPALPAAMTVGTIYAQSRLKKQGIFCISPPRINVCGKIKMI 498

  Fly   631 CFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDR-LPFDHFLFGMVTCHSITILNGRMMGDPL 694
            ||||||||||:|||:|||||..:||  .:|:....| ||...||..:.:|||:|:|.|..:||.:
 Frog   499 CFDKTGTLTEEGLDVWGVVPLDNTN--FLPITHDPRCLPDGPFLHSLASCHSVTLLKGSPIGDLM 561

  Fly   695 DLKMFESTGWELEDSNNIPD--TEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLL 757
            |:||.|||.|.| ||.:..:  ||.:|.....:::.|     .:.|...|.|:.:
 Frog   562 DVKMMESTNWTL-DSQDTDEQMTEHFGTKVLAVMKPP-----PIDEQPHGPKHHV---------- 610

  Fly   758 ATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNY 822
                        ..|::|.|||:||||||||:::...|...::|.||:|||:..|||..::|.::
 Frog   611 ------------PIGVLRRFPFSSALQRMSVISKLPGDSPSHLYMKGAPEMVASLCKSDTVPPDF 663

  Fly   823 SQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINA 887
            |..|.::.|.|||::...:|.||....:...|.::||.||.::.||||:|::|.|||:|..||:.
 Frog   664 SAMLKQYTKDGYRVLGFGYKTLSSVKTFEDAQLVARESVEQDLSFLGFLIMKNVLKPETAPVIHE 728

  Fly   888 LNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADP--IGDSANIQTNTGTECNFDNSS 950
            |..|.|||:|:||||:|||::||..|.||..::.|......|  :..:|:::
 Frog   729 LRRANIRTVMVTGDNMLTAVNVAGSCHIVGVTEKVYFASVSPPSLNKAASLR------------- 780

  Fly   951 DKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAE 1015
                                          |.|..|.          .||.....:.:...::.:
 Frog   781 ------------------------------FIPADPA----------PMEGAQEALYQQGGAFLD 805

  Fly  1016 SGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLT 1080
            .|                                   ..| |||:||::..:.|:||:.:..:|.
 Frog   806 KG-----------------------------------PYC-FAMNGKSFAALCDHFPDLLPKILV 834

  Fly  1081 RGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNP 1145
            |.:|:||||||||..||...|||:|||.|||||||||||||.|..|:|||:.|||:|||||||..
 Frog   835 RSAIFARMSPDQKTQLVQNFQNLNYCVGMCGDGANDCGALKAADVGVSLSDAEASVASPFTSRTS 899

  Fly  1146 TISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAF 1210
            .|..|..:|:|||.:|.|||.:|||||.|||.|||:.:|||::::||.|.|:||.||.:.::.|.
 Frog   900 NIECVPALIREGRCSLETSFVMFKYMALYSLTQFITALILYTVNTNLGDLQFLYFDLVITTLVAI 964

  Fly  1211 FFGKTESFDGMLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADED-- 1273
            ..|:|.....:.::: ||.||||...|.||:|...::...|:.....:..|.||......:..
 Frog   965 LMGRTGPAAELGIKR-PLGSLISIPVLGSLVLQTILILIIQLIPLFLVQNQSWFVPVNVTNPQTV 1028

  Fly  1274 HLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWVAS 1338
            ||..:||..:||:|.|||||||.|.|||.|:||.|::|.|..|..:..|.:.:::...|.|::.|
 Frog  1029 HLPNYENTVLFCVSGFQYIILAVVLSKGYPFRKALYTNVPFLLLLLALLALGLWITFAPLDFMKS 1093

  Fly  1339 FFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNWVTSKQKYMRLEHDI 1403
            ..||:....:.|:.|::...|.:||. .|:....::|....  .:||.:.....|:.|.|:|.::
 Frog  1094 LLQLVTYSDINFKGVLVGLAAINFIA-AFILEMALDYGFLN--CLKRLRKKTGPKKLYKRIEKEL 1155

  Fly  1404 SNIKNWPPITEVYEP 1418
            ....:||||.:...|
 Frog  1156 EGQLSWPPIEQTLHP 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	33/150 (22%)
		P-type_ATPase_cation	326..1281	CDD:319842	380/973 (39%)
atp13a2	XP_031761296.1	P-ATPase-V	29..1098	CDD:273738	451/1213 (37%)