DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp13a5l.2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_004914422.3	Gene:	atp13a5l.2 / 101733684	XenbaseID:	XB-GENE-22167922	Length:	1193	Species:	Xenopus tropicalis

Alignment Length:	1318	Identity:	451/1318 - (34%)
Similarity:	669/1318 - (50%)	Gaps:	228/1318 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217
            |||..::::|::.|||....|...|......:.|.||::.:|...|.::..|..|||.||:.:|:
Frog     7 LLNEGEDNEMELFGYRTVRWRQTLCIIGYIFSLGFLRVLFYWKPELDVWCQCIPCSLSEADVILL 71

  Fly   218 -TEDYQGKHKMYHVKQI--------------QVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQ 267
             |.|   :.|.|:.|::              |::|..|                       :::.
Frog    72 RTTD---ELKQYYKKKVNEIYPCIPGSKSSHQIITGEN-----------------------SIMS 110

  Fly   268 LSVHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQ--RGLPVHEQIS 330
            .|:      .|....||....:::.||||....:||:...|:..:.||..|.:  .||...||..
Frog   111 RSL------IKPQGKIRYIEVQKIRYAWNTVEGQFQKNGILEEELSCSDIHSKFGSGLTQEEQEF 169

  Fly   331 RRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVL 395
            |:.|.|.|:|.|.::....|||.::.||||:||.:|:.:|.|..|:|...:||.|::..|..::.
Frog   170 RQQVCGLNKIEVEIKPLWVLLFTDIFNPFYIFQAYSLSVWATSGYFYNGGIILSMTILSICATLY 234

  Fly   396 QTKKNQDVLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI 458
            ..:|....|.|..  ||:....|:...|..||:.::::||||:|.|..|...|.|||:||||:|.
Frog   235 NLRKQSVKLHKMALSYNSVMVTVLRKNGEVKEVESQSLVPGDVIIITGSKLFLPCDAVLISGSCT 299

  Fly   459 LDESMLTGESVPVTKTPLPSKRDMIFDK----TEHARHTLFCGTKVIQTRYIGSKKVLAFVINTG 519
            ::|.||||||:|:||..||:....:..|    .::.||.|||||:||||:..|...|.|.|:.||
Frog   300 INEGMLTGESIPITKNALPNTEGTVPWKLQCGEDYKRHVLFCGTEVIQTKAHGLDLVKAVVLQTG 364

  Fly   520 NITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDL 584
            ..||||:|:|:|||..||:.:..:::.:||..|..||..|.|||.|...:.|....:..|.||.|
Frog   365 FNTAKGDLVRAILYNKPVNVRLHKEAIRFIFVLVGIASCGVIYTAVIYTINGASVSQTVVRSLHL 429

  Fly   585 ITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVV 649
            :|..|..||||::|:|...||||||...||||.|:.||:||.:|..|||||||||||.||:.|||
Frog   430 LTAAVNAALPASLTIGLLNAQKRLKKLGIFCIRPQRINIAGQLNLVCFDKTGTLTEDSLDLCGVV 494

  Fly   650 PKSSTNQFQ-IPL-KSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNI 712
            | |..|.|| |.| .|.:.||:...|..|.:|||:.:|:|.:.|||||:||||.||||||:.:.
Frog   495 P-SDGNSFQDIHLFTSGETLPWGPVLGAMASCHSLIMLDGEIQGDPLDIKMFEGTGWELENHSK- 557

  Fly   713 PDTEKYGILYPTILRQ-PRGG---LSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGI 773
            ..||:.|.:..|:::. ||.|   :.|:|                                   |
Frog   558 HGTEESGSISSTVVKPGPRAGKVPVEGIA-----------------------------------I 587

  Fly   774 VREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIA 838
            :.:|||:|:|||||||.:...:....|:.||:|||:.|.||.:::|.|.|::|..:..:|:|::.
Frog   588 LHQFPFSSSLQRMSVVAQITGESGLTVFMKGAPEMVVKFCKQETVPLNLSKKLEFYTTQGFRVLG 652

  Fly   839 IAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNI 903
            :.::.| .|.:...:|.|.||.||.::.|||.:||||.|||:|..|:..|..||||::||||||:
Frog   653 LGYRLL-EKESLQIIQHLERETVEKDIIFLGLLILENNLKPETRGVLQELTEAKIRSVMITGDNL 716

  Fly   904 LTAISVARDCGIVSPSQSVITVHA-DPIGDS-ANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKT 966
            .||:.:...||::..|..:||:.| :|..|| |.|...|.||               |.:.|.|.
Frog   717 QTALHIGVTCGMIPKSSKIITIEAKEPQNDSPAAITWKTMTE---------------THENGHKE 766

  Fly   967 SRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTID 1031
            |.::          ||                                              ..|
Frog   767 SGSH----------FD----------------------------------------------ISD 775

  Fly  1032 TWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQAL 1096
            .|.||            |:..:...||.|||::||:..:|...:..:|..|:|:|||:|.||..|
Frog   776 KWDHN------------SFSTEAFHFATDGKSFQILLQHFYNLVPKILQNGTIFARMTPRQKSVL 828

  Fly  1097 VIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAAL 1161
            :.|.|.|||||.|||||||||||||:|..|||:|:.|||:||||||:.|.||.|..:|||||.:|
Frog   829 IEEFQKLDYCVGMCGDGANDCGALKMASVGISVSQLEASVASPFTSKIPNISCVPLLIKEGRNSL 893

  Fly  1162 VTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQV 1226
            ||||.:||::...::|:..|:.||:.....:.:..||..|:.| ::...|.|........|....
Frog   894 VTSFFMFKFLTMITVVELTSLGILFWKQKIIGEWHYLLQDIAL-TLPITFIGSLNGPAPKLAPYR 957

  Fly  1227 PLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWF------KAFEPADEDHLGCFENYTM-- 1283
            |...::|...|.|:.||.......|||.:|.|.||||:      .|..|.:::.    .|.||
Frog   958 PSGHIMSPPLLLSVSLHFLFTIILQVTAFVLLQQQPWYNESDVVSACLPLNQNS----GNVTMRE 1018

  Fly  1284 ------------FCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWV 1336
                        :.::|...|.|.||..||.|:||.:::|:.|.|...:::.:.::|:....:.:
Frog  1019 PSMSVNYLTTMEWIVTSMNIITLEFVLCKGQPFRKSIYTNYLLVLLLTIHVAVYIFLLFADIESI 1083

  Fly  1337 ASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNWV--------TSK 1393
            ...|:.:..|     |....|.....:.| ||.|:.||..:     ::.:|.|:        .||
Frog  1084 YLLFEAVCTP-----YYWRVYIFVMLLVH-FVISYAVEEGI-----LENKKLWILIKRLCKYESK 1137

  Fly  1394 QKYMRLEHDISNIKNWPP 1411
            .:|.||:..:.....|||
Frog  1138 SQYKRLQSSLELDTEWPP 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	30/147 (20%)
		P-ATPase-V	173..1355	CDD:273738	427/1232 (35%)
		E1-E2_ATPase	381..621	CDD:278548	104/245 (42%)
		Cation_ATPase	<758..813	CDD:289987	19/54 (35%)
		HAD_like	<1087..1137	CDD:304363	34/49 (69%)
atp13a5l.2	XP_004914422.3	P5-ATPase	12..133	CDD:403569	32/152 (21%)
atp13a5l.2	XP_004914422.3	P-type_ATPase_cation	165..995	CDD:319842	366/951 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm47549
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010