DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp13a4

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001186977.1	Gene:	atp13a4 / 100498523	XenbaseID:	XB-GENE-978090	Length:	1203	Species:	Xenopus tropicalis

Alignment Length:	1352	Identity:	475/1352 - (35%)
Similarity:	695/1352 - (51%)	Gaps:	228/1352 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217
            ||||.:|::|.:.||:..:.|...|......:.|.|.|:.:|....:::|.|..||||||..||:
Frog    12 LLNPGEENEMDIFGYKTHICRKVLCIIGYIFSLGFLWLLFYWKPEWHVWANCVPCSLEEASVVLL 76

  Fly   218 --TEDYQGKHKMYHVKQIQVLTSSNLKT---LLEKEQQSIERTHIECDHVENVLQLSVHFTSAQF 277
              |:|:: :.....||.|| |:|.:.||   ..:....:|.:..|       :.:|.|.:...|
Frog    77 RTTDDFK-QTSWKKVKWIQ-LSSKDFKTYRAATKDPDSTINKAII-------MPELKVRYVQVQ- 131

  Fly   278 KKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQ--QRGLPVHEQISRRIVFGDNEI 340
                        ::.|.|:|...:|.:...|:.:..||..|.  :.|:.:.|:..||::.|.|.|
Frog   132 ------------KIRYIWDNIEKQFTKAGILEDHYSCSSIHAMFESGVALEEEGIRRLICGPNII 184

  Fly   341 TVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQ 405
            .|.:.....||..||||||||||||||.|||...|..|:..|:|||:..|.:||...::....|.
Frog   185 DVGIIPIWKLLVKEVLNPFYVFQLFSVCLWFAEKYIEYSVAIILMSLICIFLSVYTLRQQSVKLH 249

  Fly   406 KTVYNTGNAWVV---DHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLTGE 467
            |.|.:..|..|.   :.:|:. :|.:|.:.||||:.| .....|.|||:|..|.||::|||||||
Frog   250 KLVESHNNITVSVYGEDRGIF-DLESRHLAPGDILVI-KRNTLLPCDALLFKGGCIVNESMLTGE 312

  Fly   468 SVPVTKTPLPSKRDMIFDKTE---------HARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITA 523
            |:||||||||:.     |.||         :.||.|||||:|||.:...:..|.|.|:.||..||
Frog   313 SIPVTKTPLPNT-----DNTEPWKVHSVHDYKRHVLFCGTQVIQVKASYNSPVKAVVLRTGFNTA 372

  Fly   524 KGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIV 588
            ||:|:||||||.||:|:..:|:..|:..|...|.:|.||.:....|.|:.|.::.:::||:|||.
Frog   373 KGDLVRSILYPKPVNYRLYRDAVIFLCTLIGTAFIGMIYAICVFSLSGSAPGEVVLKALDVITIA 437

  Fly   589 VPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSS 653
            ||||||||:|.|..|||:||:.:.||||||:.||:.|.||..||||||||||||||:||||| ::
Frog   438 VPPALPAALTAGIMYAQRRLEKAGIFCISPQRINLCGMINLFCFDKTGTLTEDGLDLWGVVP-AN 501

  Fly   654 TNQFQ--IPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTE 716
            ..:||  |.|.....||:......|.||||:.:|:|.:.|||||.||||||.|.|||......||
Frog   502 GYRFQNVIILSPDSSLPWGPLFGAMATCHSLIVLDGNVQGDPLDQKMFESTCWVLEDQQEDNMTE 566

  Fly   717 KYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTS 781
            .    .|..:.:|       ..|.|....|              ||.         |:::|||:|
Frog   567 N----MPQRIVKP-------GPTTSSDVIE--------------GIV---------ILQQFPFSS 597

  Fly   782 ALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSH 846
            :||||||:|:.|:...:.||.||:|||:...||..::|.|:..:|:.:.|:|:|:|.:|:|.|..
Frog   598 SLQRMSVITQVLNGDEYAVYLKGAPEMVASFCKTDTVPINFPDELAFYTKQGFRVIGLAYKILDI 662

  Fly   847 KMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVAR 911
            | ::.|:..|.|||||:::.|||.::||||||.:|..|:..||.||:|::||||||:.||::||:
Frog   663 K-DHKKLLTLKREEVESDLIFLGLLVLENRLKLETRPVLKELNRAKVRSVMITGDNLQTAVTVAK 726

  Fly   912 DCGIVSPSQSVITVHA-DPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSC 975
            :.|::|...:||.:.| :|.|  :::.|.|                 :||..|.|:........|
Frog   727 NSGMISEGSNVILIEAKEPSG--SDLATIT-----------------WTLVDGIKSKNYDFMDIC 772

  Fly   976 FNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAEL 1040
            .:.                             |..|..||..|                |..
Frog   773 ISM-----------------------------EEVSKPAEENL----------------HYH--- 789

  Fly  1041 GIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDY 1105
                            |||:|.|:|::..:|...::.:|..|:|:|||||.||..||.|.|.|.|
Frog   790 ----------------FAMNGSTYQVIIQHFNNLLQKILIHGTIFARMSPGQKSNLVEEFQKLGY 838

  Fly  1106 CVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKY 1170
            .|.|||||||||||||:||.||||||.|||:||||||..|.|..|.::||||||||||||.:|||
Frog   839 SVGMCGDGANDCGALKMAHVGISLSEQEASVASPFTSNTPNIECVPRLIKEGRAALVTSFCVFKY 903

  Fly  1171 MAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISST 1235
            ||.||::|:|.|::||...:...:.|:|:.||.:.::.:.......::. .|....|.:.|||..
Frog   904 MALYSMIQYIGVLLLYWEKTTYANYQFLFQDLAITTVISVTMSLNHAYP-RLSSFKPPAQLISPP 967

  Fly  1236 PLASLLLHLTVVTAFQVTCWVHLHQQPWF------------------KAFEPADED--------- 1273
            .|.|:|:::.:....||..:|.:.:|.|:                  ....|...|
Frog   968 LLLSVLINIILSLILQVCGFVIVQKQQWYISDLSSIYSACVPTNQSLSTSRPVSNDTNLTTSANS 1032

  Fly  1274 ----HLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSD 1334
                ....:||.|::.:::...:|:|.|.|||.|:|:|:::|:...|...|...:.::.:.....
Frog  1033 AEISDFQSYENTTIWLLATLNCLIVALVVSKGKPFRQPIYTNYIFILVIAVQFAVCLFFLFADIQ 1097

  Fly  1335 WVASFFQLIVPPTM---RFRYVMLAYGAASFIC-HIFVESFLVEYLVFKKYQVKREKNWVTSKQK 1395
            .:.....|:..|.:   ....::|...|.|:|. ...||:..:...:.|.:..|       ||..
Frog  1098 NLYKALDLVCTPLIWRGAILIMLLITLAVSYIAEEAIVENRALWNAMKKLFHYK-------SKSP 1155

  Fly  1396 YMRLEHDISNIKNWPPITEVYEPNNLIDCET--------EQPTYVSLHAEQN 1439
            |.||:..:.....|||:...       ||..        |:..||:...|.|
Frog  1156 YKRLQRLLKKDPEWPPLDRK-------DCAAQGNAALNGEKGYYVNPTFESN 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	35/137 (26%)
		P-ATPase-V	173..1355	CDD:273738	444/1237 (36%)
		E1-E2_ATPase	381..621	CDD:278548	112/251 (45%)
		Cation_ATPase	<758..813	CDD:289987	22/54 (41%)
		HAD_like	<1087..1137	CDD:304363	37/49 (76%)
atp13a4	NP_001186977.1	P5-ATPase	17..133	CDD:289194	35/137 (26%)
		P-ATPase-V	18..1119	CDD:273738	448/1249 (36%)
		Cation_ATPase_N	<164..214	CDD:279080	24/49 (49%)
		E1-E2_ATPase	224..467	CDD:278548	110/249 (44%)
		Cation_ATPase	<589..631	CDD:289987	21/41 (51%)
		COG4087	<817..>866	CDD:226572	36/48 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	873	1.000	Inparanoid score	I406
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm47549
Panther	1	1.100	-	-	O	PTHR45630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R101
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.110