DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp13a5l.1

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_012818778.2	Gene:	atp13a5l.1 / 100496476	XenbaseID:	XB-GENE-22167918	Length:	1199	Species:	Xenopus tropicalis

Alignment Length:	1302	Identity:	423/1302 - (32%)
Similarity:	668/1302 - (51%)	Gaps:	195/1302 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217
            |||..::::|:|.|||....|...|......:.|.||.:.:|...:.::..|..|||.||:.:|:
Frog     7 LLNQGEDNEMEVFGYRTVRWRRALCIIGYIFSLGFLRALFYWKPEVDIWCQCIPCSLSEADVILL 71

  Fly   218 --TEDYQGKHKMYHVKQIQVLT----SSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQ 276
              |:|    |:.:..|::..::    .|.....:.|:...||:                    :.
Frog    72 RTTDD----HREFLKKKVMEISDYTQGSKSGHQVTKKNSIIEK--------------------SL 112

  Fly   277 FKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQ--RGLPVHEQISRRIVFGDNE 339
            .||...||....|::.|.||....:|::|..|:..:.||..|.:  .||...||..|:.:.|.|.
Frog   113 MKKTGKIRYVEAKKIRYVWNTIEGKFKKIGNLEEELSCSDIHSKFGSGLTAEEQAIRQQICGPNS 177

  Fly   340 ITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVL 404
            |.|.:.....||..|:.||||:||.:|:.:|.:..|..::.|||.|::..:..:|...:.....|
Frog   178 IEVEVTPIWILLIKEIFNPFYIFQAYSLCIWMSCGYLEFSSVILAMTILSVIATVYNLRVQSVKL 242

  Fly   405 QK--TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLTGE 467
            .|  ..||:....|:...|..||:.::::||||:|.:..:...|.||||||||.|.::|.|||||
Frog   243 HKMSISYNSIMVTVLHKNGEVKEVESQSLVPGDVIILSENKRFLPCDAILISGGCTVNEGMLTGE 307

  Fly   468 SVPVTKTPLPSKRDMIFDK----TEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELI 528
            |.||:|..||.....:..|    .::.||.|||||:||||:..|...|.|.|:.||..||||:|:
Frog   308 STPVSKVSLPWVESSMPWKLQCGEDYKRHVLFCGTEVIQTKAHGLDLVKAVVLQTGFNTAKGDLV 372

  Fly   529 RSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPAL 593
            |:|||..|::.|..:::.:|:..|..||.:|..||.......|....:|.:.|..::||.|...|
Frog   373 RAILYNKPMNIKLHREAMRFLLVLVFIALLGVAYTAAAFKKNGASVHEIVLMSFLMLTIAVNATL 437

  Fly   594 PAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQ 658
            ||::|:|..|.|.|||...||||||:.|.:||.:|..|||||||||||.||:.||:|.:..:...
Frog   438 PASLTLGLLYGQTRLKKLGIFCISPQRIILAGQLNLVCFDKTGTLTEDSLDLLGVLPSNDKSFQD 502

  Fly   659 IPLKSVDR-LPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILY 722
            |.|.|..: :|:...|..:.:|||:.:::|:|.||||||||||.||||.|...:
Frog   503 IHLFSSGKAIPWSPLLGAIASCHSLIMVDGKMQGDPLDLKMFEGTGWEFESHAS----------- 556

  Fly   723 PTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMS 787
                       .|..:.||.|...:|...|.:: :...||:         |:.:.||:|:|||||
Frog   557 -----------HGTKDGESISCTMVKPGPSAEE-VPVEGIA---------ILHQLPFSSSLQRMS 600

  Fly   788 VVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTK 852
            |:.:...:....|:.||:|||:.|.|||:::|.|.|.:|..:..:|:|:|.:|::.| .|.....
Frog   601 VIAQITGETDLTVFMKGAPEMVVKFCKPETVPHNISTKLDYYTTQGFRVIGLAYRLL-EKEGLPA 664

  Fly   853 VQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVS 917
            ::.|.|:.:|.::.|||.:||||||||:|..|:..|:.||||.:|:||||:.||:::.:.||:|.
Frog   665 IEHLERDMIEADLIFLGLLILENRLKPETNPVLQELSTAKIRNVMVTGDNLQTALNIGKHCGMVP 729

  Fly   918 PSQSVITVHA-DPIGD-SANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNL 980
            .|..:|.:.| :|..| .|::.....|| |.:|.                      :|..|..
Frog   730 KSSKMIIIEASEPQKDVPASLTWKIITE-NQENG----------------------YKESFQG-- 769

  Fly   981 FDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHT 1045
                            ||     :::|                       |.|..|.::
Frog   770 ----------------FH-----TVMN-----------------------DKWNPNTSQ------ 784

  Fly  1046 PDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMC 1110
            |:|..      ||:|||::||:..:|...:..:|..|:|:|||:|.||.:||.|.:.|:|.|.||
Frog   785 PEEFH------FAIDGKSFQIMLQHFYNVVPKVLLNGTIFARMTPKQKSSLVEEFRKLEYNVGMC 843

  Fly  1111 GDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYS 1175
            |||||||||||:|:.|:||||.|||:||||||:.|.|..|..:|||||..||.||.:||:::..:
Frog   844 GDGANDCGALKMANVGVSLSELEASVASPFTSKIPNIECVPMLIKEGRNTLVASFSMFKFLSVLT 908

  Fly  1176 LVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISSTPL 1237
            ::...:::.|:...:.|::.|||..|:.::.....    |.|.:|...:..|.   ..|:|.:.|
Frog   909 MIALTALVFLFWKYTFLSNFQYLMQDVAIVIPVCL----TGSLNGPAPKLAPFRPPGQLLSPSLL 969

  Fly  1238 ASLLLHLTVVTAFQVTCWVHLHQQPWFK---------AFEPADEDHLG----CFENY---TMFCI 1286
            .|:.||:.:....|||.:|.|.||||:.         .|..:.|:.:.    ..|.|   |::.:
Frog   970 LSVFLHVLLTVGLQVTAYVLLQQQPWYNESDVFSACLPFNHSAENIIAKVPTITETYLATTIWIV 1034

  Fly  1287 SSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWVASFFQLIVPPTMRFR 1351
            :...||::..|||||.|:|:||::|:.|.::.|:.....::.:....:.:.:.|:.:..| ..:|
Frog  1035 TGMNYIVIEIVFSKGRPFRQPLYTNYLLIISIILQFAAFLFFLFGDLEVIYTTFEAVCTP-FYWR 1098

  Fly  1352 YVMLAYGAASFICHIFVESFLVE----YLVFKK---YQVKREKNWVTSKQKYMRLEHDISNIKNW 1409
            ..:|......|:....:|..::|    :|:.|:   ||         ||.:|.:|:..:.....|
Frog  1099 VYILVMVLVHFVLSYAIEEGILENRNLWLLIKRLCNYQ---------SKSQYRKLQRRLMMDTEW 1154

  Fly  1410 PP 1411
            ||
Frog  1155 PP 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	31/138 (22%)
		P-ATPase-V	173..1355	CDD:273738	400/1217 (33%)
		E1-E2_ATPase	381..621	CDD:278548	98/245 (40%)
		Cation_ATPase	<758..813	CDD:289987	19/54 (35%)
		HAD_like	<1087..1137	CDD:304363	33/49 (67%)
atp13a5l.1	XP_012818778.2	P5-ATPase	12..132	CDD:403569	32/143 (22%)
atp13a5l.1	XP_012818778.2	P-type_ATPase_cation	164..996	CDD:319842	340/949 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm47549
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010