DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and LOC100494846

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_002932273.2	Gene:	LOC100494846 / 100494846	-ID:	-	Length:	1189	Species:	Xenopus tropicalis

Alignment Length:	1311	Identity:	430/1311 - (32%)
Similarity:	660/1311 - (50%)	Gaps:	213/1311 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217
            :||..||:::::.||:....|...|.....::.|.|:|:.:|...|.::..|:.|.|.||:.||:
Frog     7 VLNQGQENELELFGYKTVWWRQALCVVGHIISLGFLQLLFYWRPELDVWCRCAPCRLMEADVVLI 71

  Fly   218 -TEDYQGKHKMYHVKQI--------------QVLTSSN---LKTLLEKEQQSIERTHIECDHVEN 264
             |.|   :|:.|..:::              |::|..|   .|.:.|.|
Frog    72 RTTD---EHREYSKRKVLEISPCTGGSKPVHQIVTEKNSIISKLITEPE---------------- 117

  Fly   265 VLQLSVHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPC--SYYHQQRGLPVHE 327
                            ..:|....:::.||||....:||||..||..:.|  .|.....||...:
Frog   118 ----------------GRMRYMEVQKIRYAWNTVEGKFQRIGVLDEELSCLDIYSKFGSGLSPED 166

  Fly   328 QISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITV 392
            :..|:.|.|.|.|.|.::....|||.|:.|||||||.:|:.||.:.:|..|||.||.|::..:..
Frog   167 REIRQRVCGPNSIEVKIKPVWVLLFKEIFNPFYVFQAYSICLWLSNNYVEYACAILAMTLVSVAA 231

  Fly   393 SVLQTKKNQDVLQK--TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISG 455
            ::...:.....|.|  ..:|:....|:...|..||:..:::||||:|.:..:..:|.||||||||
Frog   232 TIYNLRAQSVKLHKMSISFNSIMVTVLHKNGELKEVEAQSLVPGDVIVLAETNRSLPCDAILISG 296

  Fly   456 NCILDESMLTGESVPVTKTPLPSKRDMIFDKT----EHARHTLFCGTKVIQTRYIGSKKVLAFVI 516
            .|.::|.|||||||||||.|||.....:..||    ::.:|.||||:::|||:....:.|.|.|:
Frog   297 GCTVNEGMLTGESVPVTKIPLPCSEGSVPWKTQSGDDYKKHVLFCGSELIQTKAQSQELVKAVVL 361

  Fly   517 NTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVES 581
            .||..|.||:|::||||...::.|..:.:...:..|.:......:||.|.............:..
Frog   362 QTGFNTTKGDLLKSILYNKSINVKLHRQAMYVVLILVVFTLGEAVYTAVIFTYYEASVQDTVLMC 426

  Fly   582 LDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMW 646
            |.::::.|..||||::|:|..|||.|||...||||||:.||:||.:|..|||||||||||.||:.
Frog   427 LIVLSVAVNAALPASLTLGLLYAQTRLKKLGIFCISPQRINLAGQLNLFCFDKTGTLTEDFLDLH 491

  Fly   647 GVVPKSSTNQFQIPLKSVDR-LPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSN 710
            ||||.|..:...|...:..: ||:...|..|.:|||:.:|||:|:|||||:||||.||||.:  :
Frog   492 GVVPFSGGSFQDIHFFTTGKTLPWGPLLGAMTSCHSLIMLNGKMLGDPLDVKMFEGTGWEFK--S 554

  Fly   711 NIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVR 775
            :.....|.|.|....|.:|..| :|....|                    ||:         |:.
Frog   555 HAAHRTKDGELISCTLVKPAAG-AGEDPVE--------------------GIA---------ILH 589

  Fly   776 EFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIA 840
            :|||:|:|:||||:|:.:.::...|:.||:||::.:||||.::|.|.|::|..:..:|:|:|.:|
Frog   590 QFPFSSSLKRMSVITQIIGERDLTVFVKGAPEVVIELCKPGTVPPNVSEKLDYYTTQGFRVIGLA 654

  Fly   841 FKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILT 905
            ::...:: :...:..:.|:.:|.::.|||.:||||||||:|..|:..|.||.||.:||||||:.|
Frog   655 YRLFMNE-SLPDLHHIERDMIETDLIFLGLLILENRLKPETISVLQELAAANIRNVMITGDNLQT 718

  Fly   906 AISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAY 970
            |:::..:||::..|..:|.|.|                    |...||.....|
Frog   719 ALNIGTNCGMIPKSSKLILVEA--------------------NEPQKHVPASIT----------- 752

  Fly   971 LFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTH 1035
                                  .|||...|.         :.:.||.||       :...|.|.|
Frog   753 ----------------------WKTIIQNEE---------NKHKESILP-------INMNDGWNH 779

  Fly  1036 NDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIEL 1100
            |..:....|            ||||||.::|:..:|...:..:|..|:|:|||:|.||.:|:.|.
Frog   780 NTFQPVKYH------------FAMDGKAFEILLQHFYNLVPKVLLNGTIFARMTPRQKSSLIEEF 832

  Fly  1101 QNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSF 1165
            |.:||.|.|||||||||||||:|:.||||||.|||:||||||..|.|..|..:|||||.|||:||
Frog   833 QKIDYHVGMCGDGANDCGALKMANVGISLSELEASVASPFTSNIPNIKCVTTLIKEGRNALVSSF 897

  Fly  1166 GIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDG---MLVEQVP 1227
            .:||::...:|:...|.::|:...:.|.:.|:...|:|::.:|:.    |.|.:|   .|....|
Frog   898 TVFKFLTMVTLLALTSFVLLFLKQALLGNIQFTLQDIGIMVVFSL----TASLNGPAPKLAPYRP 958

  Fly  1228 LSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFE--NY--------- 1281
            ...|:|.:.|.|:.||..:..|.:||.::.|.||||..     :.|.:...:  |:
Frog   959 PGQLLSPSLLLSVTLHCLLNIALEVTAFLLLQQQPWIN-----ESDVISACQPLNHSTGNVTTTE 1018

  Fly  1282 -----------TMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDW 1335
                       |:|.|||..||:|.||||||.|:||.|.:|:.|....::.:.::::|:....:.
Frog  1019 VASASAASLVTTVFFISSMNYIVLEFVFSKGRPFRKRLHTNYLLSFMMVLQVAVLLFLLFADIES 1083

  Fly  1336 VASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNWVTSKQKYMRLE 1400
            |.:..:|...| ..:|..:|..|...|.....:|..::|......: :||..|: .||..|.:|:
Frog  1084 VYTALELACTP-YYWRVYILIMGLVHFAVSYAIEEGIIENRSLWLW-LKRRSNY-QSKSLYRKLQ 1145

  Fly  1401 HDISNIKNWPP 1411
            ........|||
Frog  1146 RRSETDTEWPP 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	29/150 (19%)
		P-ATPase-V	173..1355	CDD:273738	409/1233 (33%)
		E1-E2_ATPase	381..621	CDD:278548	88/245 (36%)
		Cation_ATPase	<758..813	CDD:289987	18/54 (33%)
		HAD_like	<1087..1137	CDD:304363	34/49 (69%)
LOC100494846	XP_002932273.2	P5-ATPase	12..128	CDD:372092	29/150 (19%)
LOC100494846	XP_002932273.2	P-type_ATPase_cation	165..994	CDD:319842	341/946 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm47549
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010