Protein Alignment anne and atp4a

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_031762229.1
• Gene: atp4a / 100488221
• XenbaseID: XB-GENE-486104
• Length: 1031
• Species: Xenopus tropicalis
• Alignment Length: 1241
• Identity: 254/1241 - (20%)
• Similarity: 423/1241 - (34%)
• Gaps: 382/1241 - (30%)

  Fly   307 GLDLNIPCSYYHQQRGLPVHEQI---SRRIVFGDNEITVP----------LRDFKTLLFLEVL-- 356
            |:|:.|.    .:.:|....|::   .:.:...|:|||:.          .:..|.....|:|
 Frog    21 GMDVKIK----KKSKGSKKQEKLESMKKEMDINDHEITIEELEQKYNTNVTKGMKATFAAEILIR 81

  Fly   357 -----------NPFYV---FQL---FSVILWF-------------------TYDYYYYA----CV 381
                       .|.||   .||   ...::|.                   :.|..|.|    .|
 Frog    82 DGPNELKPPKGTPEYVKFARQLAGGLQCLMWVAAVICLIAFGIECAQGDLTSADNLYLAITLIAV 146

  Fly   382 ILLMSVFGI-----TVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPS 441
            :::...||.     :.:::.:.||....|.||...|..:         ::....:|.||::|| .
 Frog   147 VVVTGCFGYYQEFKSTNIIASFKNLVPQQATVLRDGEKF---------QINANQLVVGDLVEI-K 201

  Fly   442 SGCTLHCD-AILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRY 505
            .|..:..| .|:.|..|.:|.|.|||||.|.|::|     :...:.....|:..|..|..::...
 Frog   202 GGDRVPADIRIITSQGCKVDNSSLTGESEPQTRSP-----EYTHESPLETRNIAFFSTMCLEGTA 261

  Fly   506 IGSKKVLAFVINTGNITAKGELIRSIL-----YPPPVDYKFEQDSYKFIQFLAIIAC-VGFIYTL 564
            .|      .:||||:.|..|. |.|:.     ...|:..:.|.    |:..:|.:|. .|..:.:
 Frog   262 TG------VIINTGDRTIIGR-IASLASGVGNEKTPIAIEIEH----FVDIIAGLAIFFGATFFV 315

  Fly   565 VTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINC 629
            |..:: |...::..|..:.::...||..|.|.:||......|||........:..::...||.:.
 Frog   316 VAMVI-GYPFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLARKNCVVKNLEAVETLGSTSV 379

  Fly   630 CCFDKTGTLTEDGL---DMWGVVPKSSTNQFQIPLKSVDRL------PFDHFLFGMVTCHSITIL 685
            .|.|||||||::.:   .:|          |...:.|.|..      .||...........:|.|
 Frog   380 ICSDKTGTLTQNRMTVSHLW----------FDNQIHSADTTEDQSGQSFDQTSDTWRALSKVTSL 434

  Fly   686 NGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQ 750
            ..|        ..|:|.    :|...||.....|....|.|.:       .:|...|:..|.:.:
 Frog   435 CNR--------ACFKSG----QDGVPIPKRIVIGDASETALLK-------FSELTVGNVMEYRDR 480

  Fly   751 SSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQV---FNVYCKGSPEMLKKL 812
            ..    .||                |.||.|. .:..:....|.|.:   :.:..||:||.:.:.
 Frog   481 FK----KAT----------------ELPFNST-NKFQLSIHELQDPLDLRYLLVMKGAPERILER 524

  Fly   813 C-----KPQSLP------DNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNME 866
            |     |.|.||      :.:.....:....|.|::......|:.| .|.:......||:.....
 Frog   525 CSTIMIKGQELPLDEQWKEAFQTAYMDLGGLGERVLGFCHLYLNEK-EYPRGFSFDTEEMNFPTS 588

  Fly   867 FLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHAD 928
            .|.|..|.:.:.|....|.:|:   ..|.||.||:|||:.:||.::|...||:|.....:
 Frog   589 GLCFAGLISMIDPPRATVPDAVMKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETV----- 648

  Fly   929 PIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVG 993
                                 .|...:|...::                             ||.
 Frog   649 ---------------------EDIAARLRIPVE-----------------------------QVN 663

  Fly   994 KTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFA 1058
            |                          .|:.|.|       .|..:|
 Frog   664 K--------------------------RDARACV-------INGGQL------------------ 677

  Fly  1059 MDGKTWQIVKDYFPEEM--EILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALK 1121
                     ||...||:  .:.|....::||.||.||..:|...|.|...||:.|||.||..|||
 Frog   678 ---------KDMTSEELVEALKLHPEMVFARTSPQQKLIIVESCQKLGAIVAVTGDGVNDSPALK 733

  Fly  1122 VAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTS-------FGIFKYMAAYSLVQF 1179
            .|..|:::     .||....::|   :|.:.::.:..|::||.       |...|...||:|.:.
 Frog   734 KADIGVAM-----GIAGSDAAKN---AADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKN 790

  Fly  1180 ISVMILYSIDSNLTDKQYLY----VDLGLISIFAFFFGKTESFDGMLV----EQVPLSSLISSTP 1236
            |..:..|.|        |:.    :.||.|:|. |....|:.|..:.:    .:..:..|....|
 Frog   791 IPELAPYLI--------YITASVPLPLGCITIL-FIELCTDIFPSVSLAYERAESDIMHLKPRNP 846

  Fly  1237 LASLLLH--LTVVTAFQ----------VTCWVHLHQQPWFKAF-----EPADEDHLGCFEN---- 1280
            ....|::  |.|.:.||          |..:..:.|:.||.|:     ...:..||...|:
 Frog   847 RRDRLVNEALAVYSYFQVGIIQSFAGFVDYFTVMAQEGWFPAYVLGLRSHWENQHLQDLEDSYGQ 911

  Fly  1281 --------------YTMFCISSFQYIILAFVFSKG----APYRKPLWSNWPLCLAFIVNLCIIVY 1327
                          ||:|.| |.:...:|.|..:.    :.:::..:.|..|.:|.:..||:..:
 Frog   912 QWTFSQRLYQQYNCYTVFFI-SIEVCQIADVLIRKTRRLSVFQQGFFRNKVLVIAIVFQLCLGNF 975

  Fly  1328 LVLYPSDWVASFFQLIVPPTMRFRY--VMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNWV 1390
            |...|.  :.:.|..:   .:||::  |.:.:|...|:           |...:|..|:|.....
 Frog   976 LCYCPG--MPNVFNFM---PIRFQWWLVPVPFGILIFV-----------YDEIRKLGVRRNPGSW 1024

  Fly  1391 TSKQKY 1396
            ..|:.|
 Frog  1025 YDKELY 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	224/1099 (20%)
atp4a	XP_031762229.1	ATPase-IIC_X-K	39..1031	CDD:273445	249/1219 (20%)