Protein Alignment anne and atp13a5

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_012818836.2
• Gene: atp13a5 / 100485018
• XenbaseID: XB-GENE-12441880
• Length: 1197
• Species: Xenopus tropicalis
• Alignment Length: 1342
• Identity: 479/1342 - (35%)
• Similarity: 683/1342 - (50%)
• Gaps: 252/1342 - (18%)

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217
            |||...|::|::.|||..|.|.|.|......:.|||.|:.:|.....::|.|..|.||.|...|:
 Frog    12 LLNEGMENEMEIFGYRTILWRKGLCIMGYIFSFGLLWLLFYWKPEWEVWAYCEPCLLENANVFLL 76

  Fly   218 TEDYQGKH------KMYHV-KQIQVL--TSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFT 273
            ....:.||      ...|: ||..||  ||..|.|   |::.||         :...:.:..|
 Frog    77 RSTDEFKHCSKKNLLWTHLSKQDSVLLQTSDKLST---KDEYSI---------INKAIMMPEH-- 127

  Fly   274 SAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQ--RGLPVHEQISRRIVFG 336
                    .:|..|.:::.|.|..:..:||:...|:....||..|.:  .||...||..||::.|
 Frog   128 --------KVRYIRVQKIKYVWLLSEKKFQKAGALEDLYSCSQIHSRFGSGLTQEEQTLRRLICG 184

  Fly   337 DNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQ 401
            .|.|.|.:.....|||.|||||||:||:.|:.||....|..|:.||:::::..:.::|...::..
 Frog   185 PNAIEVEVVPVWKLLFKEVLNPFYLFQIASLSLWLAEGYIEYSVVIIIITLISVILTVYDLRQQS 249

  Fly   402 DVLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESML 464
            ..|.:.|  .|:.:..|:...|.|.::.:|.:||||||.:......|.||.||:.|:||::|.||
 Frog   250 VKLNRLVESNNSASVTVLMKDGDSYDVESRQLVPGDIIVLTGKRFFLPCDCILLEGSCIVNEGML 314

  Fly   465 TGESVPVTKTPLPSKRDMIFDKTEHA------------RHTLFCGTKVIQTRYIGSKKVLAFVIN 517
            ||||:|||||||        |::|.|            ||.|||||:|||....|:..|.|.|:.
 Frog   315 TGESIPVTKTPL--------DRSESAKPWKIQSGEDYKRHVLFCGTEVIQATSTGADPVTAVVVQ 371

  Fly   518 TGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESL 582
            ||..||||:::||||||.|:::|..||:.:|:..|.:||.|||||:::...::|.....|.::|:
 Frog   372 TGFNTAKGDMVRSILYPKPMNFKLYQDALRFLMCLVVIAAVGFIYSVIVFKVKGASVRDIIIKSI 436

  Fly   583 DLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWG 647
            ..||:.:||.||||:.....|:|||||..:||||||:.|||.|.:|..||||||||||||||:||
 Frog   437 IAITVAIPPILPAAVATALMYSQKRLKKKKIFCISPQRINVCGRVNLVCFDKTGTLTEDGLDLWG 501

  Fly   648 VVPKSSTNQFQIPLKSVD--RLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSN 710
            |:| .:.|:||......|  .||:...|..|.:|||:.||:|::.|||||:||||.|.|.:||||
 Frog   502 VIP-CTENRFQKLHMFADGNDLPWCPLLGAMASCHSLLILDGKIQGDPLDVKMFEGTNWIIEDSN 565

  Fly   711 NIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEI-----KRQSSVDDLLATVGISPSQKNFD 770
                                        ||:...:.:     .|.|.|    ...||:
 Frog   566 ----------------------------TENNHNHNLLIKPGPRCSPV----PVKGIT------- 591

  Fly   771 HGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYR 835
              |:::|||:|:||||||:.:.:..:...|:.||:|||:.:.|.|:|:|.|::.:|..:.::|||
 Frog   592 --ILQQFPFSSSLQRMSVIAQAIESEENMVFMKGAPEMVTQFCLPESVPANFANELQLYTQQGYR 654

  Fly   836 IIAIAFKAL-----SHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRT 895
            :|.:|:|.|     .||.||.      |||||.::.|||.:|||||||.:|...:|.||.|.|:|
 Frog   655 VIGLAYKPLQACDKGHKENYL------REEVECSLIFLGLLILENRLKTETIPALNELNNALIKT 713

  Fly   896 IMITGDNILTAISVARDCGIVSPSQSVITVHA-DPIGDSANIQTNTGTECNFDNSSDKHYKLHYT 959
            :||||||:.|||:|||.||||.....||...| :|.|......|....|.|          ||..
 Frog   714 VMITGDNLQTAITVARSCGIVQRHGRVILAEASEPNGSIPASITWKEVETN----------LHVV 768

  Fly   960 LDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSL 1024
            .|               |:...|||                 .||...:|...|
 Frog   769 HD---------------NTETTDPE-----------------KNSDAQKSCPYY----------- 790

  Fly  1025 ASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMS 1089
                                            |||.|||:.|:..||...:..||..|:|:||||
 Frog   791 --------------------------------FAMSGKTYGIIVQYFYSLLPKLLLNGAIFARMS 823

  Fly  1090 PDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVI 1154
            |.||..|:.|.|.|||.|||||||||||||||:|||||||||.|||:||||||:...|..|.::|
 Frog   824 PGQKANLIEEFQKLDYYVAMCGDGANDCGALKMAHAGISLSEQEASVASPFTSQTANILCVPQLI 888

  Fly  1155 KEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFD 1219
            ||||||||:||.:|||:..||::|||.:::||.....:...|||:.|:|:..:.:.....|..:.
 Frog   889 KEGRAALVSSFAVFKYVTLYSMIQFICMLLLYWKLKMVGLYQYLFQDVGITILVSLTLSLTHPYQ 953

  Fly  1220 GMLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPW-----FKAFEPADEDHLGC-- 1277
             .|....|.:.|||...|.|::.::.:..|.|:..::.:.||||     ::|..|..|:....
 Frog   954 -KLAPYRPPAQLISPPLLLSIIFNILLSLASQICGFLLVQQQPWYSTSNYRACAPTTENITAVGF 1017

  Fly  1278 ---------------FENY---TMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCI 1324
                           ||||   |::.|::...||:|||||||.|:|||:::|:.......:.|..
 Frog  1018 NISNTNSTGVEENPEFENYESTTLWPITTINLIIVAFVFSKGTPFRKPIYTNYLFFCLLPIQLAA 1082

  Fly  1325 IVYLVLYPSDWVASFFQLIVPPT---MRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKRE 1386
            .::::......:...||||..||   :....::|.|         |:.||.||.|..:..:|
 Frog  1083 CLFILFADLKGLYRAFQLICTPTIWRISILIIVLIY---------FLVSFAVEELFIENRRV--- 1135

  Fly  1387 KNWV--------TSKQKYMRLEHDISNIKNWPPITEVYEPNN 1420
              |:        .|..||..|...:.|...|||:......:|
 Frog  1136 --WLYLKKICKYYSNSKYRVLYRMVQNDSRWPPVDTKQNADN 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	39/146 (27%)
		P-type_ATPase_cation	326..1281	CDD:319842	384/1003 (38%)
atp13a5	XP_012818836.2	P5-ATPase	18..141	CDD:463565	39/144 (27%)
		P-type_ATPase_cation	174..997	CDD:319842	378/964 (39%)