Protein Alignment Es2 and ESS2

DIOPT Version :10

• Sequence 1: NP_572480.1
• Gene: Es2 / 31780
• FlyBaseID: FBgn0023506
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: XP_005261339.1
• Gene: ESS2 / 8220
• HGNCID: 16817
• Length: 477
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 184/528 - (34%)
• Similarity: 265/528 - (50%)
• Gaps: 92/528 - (17%)

  Fly    13 TPGTPGSLAMEVARVQNSALAEFKKPTAMVRHKNKPKILTEEKYIEEMSKIIQRDFFPDLERLRA 77
            |||...|..:..|..:.....|..:..|..   :|.::|.||:|||.:..:||||||||:|:|:|
Human     3 TPGASASSLLLPAASRPPRKREAGEAGAAT---SKQRVLDEEEYIEGLQTVIQRDFFPDVEKLQA 64

  Fly    78 QNDYLDAESRRDFVQMAEIRERY--SLGRISGTGRSTSRRNNA---MSPATFETPVSQA---KCS 134
            |.:||:||...|..:|.:|..::  :||::|        |...   ::|||||||...|   ...
Human    65 QKEYLEAEENGDLERMRQIAIKFGSALGKMS--------REPPPPYVTPATFETPEVHAGTGVVG 121

  Fly   135 NTPLPNSRATDTPFSTDGSEKSDAEGRDTTAKLSLDAFLQKYTSEDNQSFQEIIETAEAKLRQKY 199
            |.|.|..|..:     |..|..:.|.::...  |||.||.:||||||.|||||:|.|:.:.|.::
Human   122 NKPRPRGRGLE-----DAGEAGEEEEKEPLP--SLDVFLSRYTSEDNASFQEIMEVAKERSRARH 179

  Fly   200 AVLYNHEKLSAEQLQRALMLPSIETQFEEPDPLRKIETWNYTNMNSIMYVPDGVEYTEEERVQLA 264
            |.||..|:...::.:..|.|||.|.|..|... ..:|||.|...||:||.|:||  .:||  ||.
Human   180 AWLYQAEEEFEKRQKDNLELPSAEHQAIESSQ-ASVETWKYKAKNSLMYYPEGV--PDEE--QLF 239

  Fly   265 ERKQSIQHNATR-LPD-----------------EAKHRE----MDTKKLNDEVPQNGAGGATATP 307
            ::.:.:.|..|| |.|                 .|:|::    .|.|:|   :||.       :|
Human   240 KKPRQVVHKNTRFLRDPFSQALSRCQLQQAAALNAQHKQGKVGPDGKEL---IPQE-------SP 294

  Fly   308 KVRGFDLLRSPSPRPGEAFSPIMTWGEIDGTPFRLDGGDTP-LRPTQGPSFRINENSRRENIAIA 371
            :|.||..:.:|||.||...||:|||||::.||.|::|.:|| :..|.||:|:|.|..|||.:.:.
Human   295 RVGGFGFVATPSPAPGVNESPMMTWGEVENTPLRVEGSETPYVDRTPGPAFKILEPGRRERLGLK 359

  Fly   372 LAERVSERMRNQKQMALDTARRNIGSPLIRTNMERLASMSPAAQLLATGKLGIRGTPRLRHTPSP 436
            :|...:.:.|.:||.||.....|:.|   .|......:||||.|.|.:            .|.|.
Human   360 MANEAAAKNRAKKQEALRRVTENLAS---LTPKGLSPAMSPALQRLVS------------RTASK 409

  Fly   437 MSGR--KRKVTPGVVRSTNTPILGEPKPKQQAKISTPAKN------VTIDTGSTLTDDLLKIPTK 493
            .:.|  :...||...|||:   |..|....|...||||..      :|.|..| :||:||::|.
Human   410 YTDRALRASYTPSPARSTH---LKTPASGLQTPTSTPAPGSATRTPLTQDPAS-ITDNLLQLPA- 469

  Fly   494 RRTAADFF 501
            ||.|:|||
Human   470 RRKASDFF 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Es2	NP_572480.1	Es2	47..417	CDD:430802	147/400 (37%)
ESS2	XP_005261339.1	Es2	34..402	CDD:430802	147/400 (37%)