DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Es2 and ess2

DIOPT Version :9

Sequence 1:	NP_572480.1	Gene:	Es2 / 31780	FlyBaseID:	FBgn0023506	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001082799.2	Gene:	ess2 / 324123	ZFINID:	ZDB-GENE-030131-2843	Length:	469	Species:	Danio rerio

Alignment Length:	485	Identity:	182/485 - (37%)
Similarity:	246/485 - (50%)	Gaps:	58/485 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EFKKPTAMVRHKNKPKILTEEKYIEEMSKIIQRDFFPDLERLRAQNDYLDAESRRDFVQMAEIRE 98
            |.|||        |.|||.||:|||.:.||||||||||:.:|:||.|||:||...|..:|.||..
Zfish    26 ESKKP--------KRKILDEEQYIESLEKIIQRDFFPDVSKLQAQKDYLEAEENGDLERMREIAI 82

  Fly    99 RYSLGRISGTGRSTSRRNNAMSPATFETPVSQAKCSNTPLPNSRATDTPFSTDGSEKSDAEGRDT 163
            :|.......|.|:....   ::|:|||||..::...::....|||.    ..||.:...|..:|.
Zfish    83 KYGSAMAKYTPRTYVPH---VTPSTFETPDGRSASPSSSQSKSRAA----REDGKDGEKASEKDL 140

  Fly   164 TAKLSLDAFLQKYTSEDNQSFQEIIETAEAKLRQKYAVLYNHEKLSAEQLQRALMLPSIETQFEE 228
            .   |||.||.|.|||||.||::|:|.||.|.:.::|.||..|....|:.::.|.|||.|.|..|
Zfish   141 P---SLDRFLSKNTSEDNASFEQIMELAEDKDKLRHAWLYEAENEYKERHEQNLALPSSEKQALE 202

  Fly   229 PDPLRKIETWNYTNMNSIMYVPDGVEYTEEERVQLAERKQSIQHNATRLPDEA------KHREMD 287
            ... ..:|||.|...||:||.|:|     |:...|.::.:.:.:..||..|:.      |.:...
Zfish   203 CTK-AGLETWQYKAKNSLMYYPEG-----EKDDTLFKKPREVLYKNTRFEDDPFCKALNKSQIQQ 261

  Fly   288 TKKLNDEVPQNGAGG------ATATPKVRGFDLLRSPSPRPGEAFSPIMTWGEIDGTPFRLDGGD 346
            ...||.:..|...|.      ...:|||.|:....:|||.||.|.||:||||||:.|||||:|.|
Zfish   262 AAALNAQFKQGKVGPDGKELLPHESPKVNGYGYEGAPSPAPGVAESPLMTWGEIESTPFRLEGSD 326

  Fly   347 TPL-RPTQGPSFRINENSRRENIAIALAERVSERMRNQKQMALDTARRNIGSPLIRTNMERLASM 410
            ||| ..:.||||:|.|..|||.:.:.:|...:.:.|.:||.||.....|:.| |....:.. |::
Zfish   327 TPLVERSHGPSFKIPEPGRRERLGLKMANEAAAKNRAKKQEALRKVTENLAS-LTPKGLSP-AAL 389

  Fly   411 SPAAQLLATGKLGIRGTPRLR--HTPSPMSGRKRKVTP--GVVRSTNTPILGEPKPKQQAKISTP 471
            |||.|.|............||  :||||........||  |:...|.||          .|..||
Zfish   390 SPALQRLVNRSSSKYTDKALRASYTPSPAHRSLGAKTPSGGLTTLTPTP----------TKTRTP 444

  Fly   472 AKNVTIDTGSTLTDDLLKIPTKRRTAADFF 501
            |..   |..| :||:||::| |||.|.|:|
Zfish   445 ASQ---DPAS-ITDNLLQLP-KRRKAQDYF 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Es2	NP_572480.1	Es2	47..417	CDD:286794	148/382 (39%)
ess2	NP_001082799.2	Es2	31..396	CDD:286794	148/382 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586311
Domainoid	1	1.000	221	1.000	Domainoid score	I2544
eggNOG	1	0.900	-	-		E1_KOG2627
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11184
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3319
OMA	1	1.010	-	-		QHG55516
OrthoDB	1	1.010	-	-		D1378245at2759
OrthoFinder	1	1.000	-	-		FOG0005392
OrthoInspector	1	1.000	-	-		oto40338
orthoMCL	1	0.900	-	-		OOG6_103502
Panther	1	1.100	-	-	LDO	PTHR12940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2483
SonicParanoid	1	1.000	-	-		X4333
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800