DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Es2 and Ess2

DIOPT Version :9

Sequence 1:	NP_572480.1	Gene:	Es2 / 31780	FlyBaseID:	FBgn0023506	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_071853.2	Gene:	Ess2 / 27886	MGIID:	107854	Length:	480	Species:	Mus musculus

Alignment Length:	535	Identity:	186/535 - (34%)
Similarity:	271/535 - (50%)	Gaps:	101/535 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GTPGT-PGSLAMEVARVQNSALAEFKKPTAMVRHKNKPKILTEEKYIEEMSKIIQRDFFPDLERL 75
            ||||| .|:|.:..|...:...|..:...|.|. :::.::|.||:|||.:..:||||||||:|:|
Mouse     2 GTPGTSAGALFLSSASAPSRKRAAGEAGEAGVA-RSRQRVLDEEEYIEGLQTVIQRDFFPDVEKL 65

  Fly    76 RAQNDYLDAESRRDFVQMAEIRERY--SLGRISGTGRSTSRRNNA---MSPATFETP---VSQAK 132
            :||.:||:||...|..:|.:|..::  :||:||        |...   ::|||||||   ...|.
Mouse    66 QAQKEYLEAEENGDLERMRQIAIKFGSALGKIS--------REPPPPYVTPATFETPEVHPGSAV 122

  Fly   133 CSNTPLPNSRATDTPFSTDGSEKSDAEGRDTTAKLSLDAFLQKYTSEDNQSFQEIIETAEAKLRQ 197
            ..|.|.|..|..|     |..|..:.|.::...  |||.||.:||||||.|||||:|.|:.|...
Mouse   123 LGNKPRPQGRDLD-----DAGEAGEEEEKEPLP--SLDVFLSQYTSEDNASFQEIMEVAKEKSHA 180

  Fly   198 KYAVLYNHEKLSAEQLQRALMLPSIETQFEEPDPLRKIETWNYTNMNSIMYVPDGVEYTEEERVQ 262
            ::|.||..|:...::.:..|.|||.|.|..|... ..:|||.|...||:||.|:||  .:||  |
Mouse   181 RHAWLYQAEEEFEKRQKDNLELPSAEHQAIESSQ-AGVETWKYKAKNSLMYYPEGV--PDEE--Q 240

  Fly   263 LAERKQSIQHNATR-LPD-----------------EAKHRE----MDTKKLNDEVPQNGAGGATA 305
            |.::.:.|.|..|| |.|                 .|:|::    .|.|:|   :||.
Mouse   241 LFKKPRQIVHKNTRFLRDPFSQALSRSQLQQAAALNAQHKQGKVGPDGKEL---IPQE------- 295

  Fly   306 TPKVRGFDLLRSPSPRPGEAFSPIMTWGEIDGTPFRLDGGDTP-LRPTQGPSFRINENSRRENIA 369
            :|:|.||..:.:|||.||...||:|||||::.||.|::|.::| :..|.||:|:|.|..|||.:.
Mouse   296 SPRVGGFGFVATPSPAPGVNESPLMTWGEVENTPLRVEGSESPYVDRTPGPTFKILEPGRRERLG 360

  Fly   370 IALAERVSERMRNQKQMALDTARRNIGSPLIRTNMERLASMSPAAQLLATGKLGIRGTPR-LR-- 431
            :.:|...:.:.|.:||.||.....|:.|   .|......:||||.|.|.: :...:.|.| ||
Mouse   361 LKMANEAAAKNRAKKQEALRRVTENLAS---LTPKGLSPAMSPALQRLVS-RTASKYTDRALRAS 421

  Fly   432 HTPSPMSGRKRKV----------TPGVVRSTNTPILGEPKPKQQAKISTPAKNVTIDTGSTLTDD 486
            :||||......|.          ||....:|.||:..:|                    :::||:
Mouse   422 YTPSPARSSHLKTPAGGPQTPTSTPAPGSATRTPLTQDP--------------------ASITDN 466

  Fly   487 LLKIPTKRRTAADFF 501
            ||::|. ||.|:|||
Mouse   467 LLQLPA-RRKASDFF 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Es2	NP_572480.1	Es2	47..417	CDD:286794	148/400 (37%)
Ess2	NP_071853.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		11/36 (31%)
		Es2	37..405	CDD:286794	148/400 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..480		23/84 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841842
Domainoid	1	1.000	208	1.000	Domainoid score	I2866
eggNOG	1	0.900	-	-		E1_KOG2627
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11184
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3421
Isobase	1	0.950	-	0	Normalized mean entropy	S5412
OMA	1	1.010	-	-		QHG55516
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005392
OrthoInspector	1	1.000	-	-		oto92587
orthoMCL	1	0.900	-	-		OOG6_103502
Panther	1	1.100	-	-	LDO	PTHR12940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2483
SonicParanoid	1	1.000	-	-		X4333
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740