DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Es2 and ess-2

DIOPT Version :9

Sequence 1:	NP_572480.1	Gene:	Es2 / 31780	FlyBaseID:	FBgn0023506	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001022581.1	Gene:	ess-2 / 176200	WormBaseID:	WBGene00018371	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	158/523 - (30%)
Similarity:	248/523 - (47%)	Gaps:	85/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MVRHKNKPKILTEEKYIEEMSKIIQRDFFPDLERLRAQNDYLDAESRRDFVQMAEIRERY-SLGR 104
            :|..|.:.:::.|||||..:.|||::|:||.|::::||.:||:|.:.:|..::.|::.:: |.|.
Worm    32 LVTKKIERQVVPEEKYIAGLDKIIEKDYFPHLKKMQAQKEYLEAVANKDINKIKELQMKFCSTGS 96

  Fly   105 ISGTGRSTSRRNNAMSPATFETPVSQAKCSNTPLPNSRATDT---------PFSTDGSEKSDAEG 160
            :. |.||.  |....:.:|.|.|...:..::||.|:|.:|.:         ||:   :|:.|.|.
Worm    97 VR-TDRSF--RTPITTRSTTEAPDVSSFDADTPGPSSASTSSAHDWMQSPMPFA---NEEGDNEA 155

  Fly   161 ----RDTTAKLSLDAFLQKYTSEDNQSFQEII----ETAEAKLRQKYAVLYNHEK-------LSA 210
                |....:.:|.::|.|||||||.||:|:.    |..:|:....|.....|.|       ::|
Worm   156 LNRKRKKKKEETLTSYLNKYTSEDNASFEELAKVMREREDARRPWVYKAEEEHNKNLVTRQAIAA 220

  Fly   211 EQLQRALMLPSIETQFEEPDPLRKIETWNYTNMNSIMYVPDGVEYTEEERVQLAERKQS-IQHNA 274
            |...:..:..:::.....|   ..::.|.|...|::::.|||...|..|....|.::|: |....
Worm   221 EADVQLALKHAVDADDNRP---LNVDNWAYKAWNTVLFNPDGAALTPAEIADAARKQQTEINKRG 282

  Fly   275 TRLPDEAKHREMDTKKLNDEVPQ--NGAG-----GATATPKVRGFDLLRSPSPRPGEAFSPIMTW 332
            ||.||..|.:..|.......|..  ..||     |...|| ...|.||.:|:|.|.:..||:|||
Worm   283 TRFPDSGKLKPSDEAMTRAAVSHALANAGKVDFLGNEVTP-ANSFKLLETPNPNPDDMDSPLMTW 346

  Fly   333 GEIDGTPFRLDGGDTPLR--PTQGPSFRINENSRRENIAIALAERVSERMRNQKQMALDTARRNI 395
            |||||||||||..|....  |...|.|:|.|...||.||.::.:.::.:.|:::::|:..|.
Worm   347 GEIDGTPFRLDAPDVTEHSLPGAAPVFKIPEVPYREKIAQSMNDSIAAKYRDKRKVAMRAAE--- 408

  Fly   396 GSPLIRTN-------MERLASMSPAAQLLATGKLGIR---------GTPRLRHTPSPMSGRKRKV 444
            |:...||.       .::||.:|||||.|||.|||::         .:|::....|..|..||..
Worm   409 GAHFSRTPGFGSKRVSDKLAQLSPAAQKLATKKLGLKMLPAHKSPFASPKIMSNWSRPSSSKRST 473

  Fly   445 TPGVV--RSTNTPILGEP---------KPKQQAKISTPAKNVTIDTGSTLTDDLLKIPTKRRTAA 498
            |||..  |.:.||  |..         .|..::.|.....||...|.:...|        |..|.
Worm   474 TPGSAWSRGSTTP--GSSWSQGAQTPGTPGIESMIRRKGDNVGPSTSAGAAD--------RANAG 528

  Fly   499 DFF 501
            |||
Worm   529 DFF 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Es2	NP_572480.1	Es2	47..417	CDD:286794	127/411 (31%)
ess-2	NP_001022581.1	Es2	39..437	CDD:286794	127/410 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162163
Domainoid	1	1.000	168	1.000	Domainoid score	I2317
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11184
Inparanoid	1	1.050	188	1.000	Inparanoid score	I2589
Isobase	1	0.950	-	0	Normalized mean entropy	S5412
OMA	1	1.010	-	-		QHG55516
OrthoDB	1	1.010	-	-		D1378245at2759
OrthoFinder	1	1.000	-	-		FOG0005392
OrthoInspector	1	1.000	-	-		oto19943
orthoMCL	1	0.900	-	-		OOG6_103502
Panther	1	1.100	-	-	LDO	PTHR12940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2483
SonicParanoid	1	1.000	-	-		X4333
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890