DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HNRNPA1 and HRP1

DIOPT Version :9

Sequence 1:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_014518.1	Gene:	HRP1 / 853997	SGDID:	S000005483	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	422	Identity:	121/422 - (28%)
Similarity:	181/422 - (42%)	Gaps:	108/422 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     2 SKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVE 66
            ||::..||.   .|:|||||:::||:::||.:|.::||:||..:|:||.|.|||||||:::....
Yeast   150 SKADLSKES---CKMFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKDPATGRSRGFGFLSFEKPS 211

Human    67 EVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKI 131
            .||..:..: |.:||:|::||||:.|::..:.|      |||||||..|.......::|.|:|.|
Yeast   212 SVDEVVKTQ-HILDGKVIDPKRAIPRDEQDKTG------KIFVGGIGPDVRPKEFEEFFSQWGTI 269

Human   132 EVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGR 196
            ...::|.|:.:|:.|||.|||:|..|:||::...|:........|:::| ..:.|...||:
Yeast   270 IDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKRA-EPRHMQQKSSN---- 329

Human   197 SGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGG---GGYG-------------------- 238
                     .||..|||:...|||||..:|.|......   |||.
Yeast   330 ---------NGGNNGGNNMNRRGGNFGNQGDFNQMYQNPMMGGYNPMMNPQAMTDYYQKMQEYYQ 385

Human   239 ----GSGDGYN---------------GFG------------NDGGYGGGGPGYSGGSRGYGSGGQ 272
                .:|..|.               ||.            .|.....|.|..|.......:..|
Yeast   386 QMQKQTGMDYTQMYQQQMQQMAMMMPGFAMPPNAMTLNQPQQDSNATQGSPAPSDSDNNKSNDVQ 450

Human   273 GYGNQGSGYGGSGSYD---------SYNNGGGGGFGGGSGSNFGGGGSYN-DFG--NYNNQSSNF 325
            ..||..:...||...:         .||:....|:|            || |.|  :.|::..::
Yeast   451 TIGNTSNTDSGSPPLNLPNGPKGPSQYNDDHNSGYG------------YNRDRGDRDRNDRDRDY 503

Human   326 GPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGY 357
            ....|||.  |.:|..|.||.    .|...||
Yeast   504 NHRSGGNH--RRNGRGGRGGY----NRRNNGY 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1	NP_112420.1	Globular A domain	4..94		39/89 (44%)
		RRM1_hnRNPA1	12..92	CDD:410154	36/79 (46%)
		Globular B domain	95..185		29/89 (33%)
		RRM2_hnRNPA3	105..184	CDD:409996	28/78 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216		8/33 (24%)
		RNA-binding RGG-box	218..240		10/48 (21%)
		HnRNPA1	307..344	CDD:402981	11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372		12/41 (29%)
		Nuclear targeting sequence (M9)	320..357		9/36 (25%)
HRP1	NP_014518.1	PABP-1234	<144..463	CDD:130689	100/336 (30%)
		RRM1_Hrp1p	161..236	CDD:409991	35/75 (47%)
		RRM2_Hrp1p	244..321	CDD:409767	28/77 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1143
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.920