DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPA1 and NPL3

DIOPT Version :10

Sequence 1:NP_112420.1 Gene:HNRNPA1 / 3178 HGNCID:5031 Length:372 Species:Homo sapiens
Sequence 2:NP_010720.3 Gene:NPL3 / 852042 SGDID:S000002840 Length:414 Species:Saccharomyces cerevisiae


Alignment Length:340 Identity:96/340 - (28%)
Similarity:125/340 - (36%) Gaps:133/340 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    97 RPGAH------LTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDD 155
            ||..|      |:..::||.....|.:|..|.:.|..:|.::.::|:        .|||||.|::
Yeast   111 RPPMHHRQEGELSNTRLFVRPFPLDVQESELNEIFGPFGPMKEVKIL--------NGFAFVEFEE 167

Human   156 HDSVDKIVIQKYHTVNGHNCEVRKALSK------------------------------QEMASAS 190
            .:|..| .|::.|..:..|..:....||                              .|...:|
Yeast   168 AESAAK-AIEEVHGKSFANQPLEVVYSKLPAKRYRITMKNLPEGCSWQDLKDLARENSLETTFSS 231

Human   191 SSQRGRSGSG-----------------------------------------NFGGGRG-GGFGGN 213
            .:.|...|:|                                         |.||.|| |||.|.
Yeast   232 VNTRDFDGTGALEFPSEEILVEALERLNNIEFRGSVITVERDDNPPPIRRSNRGGFRGRGGFRGG 296

Human   214 DNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQG 278
            ...|..|.|| ||||||.|  ||:||...||.|:.. |||||...|..|||||      ||.:. 
Yeast   297 FRGGFRGGFS-RGGFGGPR--GGFGGPRGGYGGYSR-GGYGGYSRGGYGGSRG------GYDSP- 350

Human   279 SGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGG 343
                 .|.|||..    ||:..|     |.||..||          :||.: |::|| |.|.|.|
Yeast   351 -----RGGYDSPR----GGYSRG-----GYGGPRND----------YGPPR-GSYGG-SRGGYDG 389

Human   344 GGQYFAKPRNQGGYG 358
                   ||  |.||
Yeast   390 -------PR--GDYG 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPA1NP_112420.1 Globular A domain 4..94
RRM1_hnRNPA1 12..92 CDD:410154
Globular B domain 95..185 25/123 (20%)
RRM2_hnRNPA3 105..184 CDD:409996 21/108 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..216 16/105 (15%)
RNA-binding RGG-box 218..240 13/21 (62%)
HnRNPA1 312..344 CDD:463312 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..372 14/42 (33%)
Nuclear targeting sequence (M9) 320..357 12/36 (33%)
NPL3NP_010720.3 PHA03247 <11..87 CDD:223021
RBD_RRM1_NPL3 126..192 CDD:409777 19/74 (26%)
RRM2_SRSF1_4_like 200..271 CDD:409776 5/70 (7%)
Blue background indicates that the domain is not in the aligned region.

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