Protein Alignment HNRNPA1 and Hrb87F

DIOPT Version :10

• Sequence 1: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_476806.2
• Gene: Hrb87F / 48535
• FlyBaseID: FBgn0004237
• Length: 385
• Species: Drosophila melanogaster
• Alignment Length: 391
• Identity: 194/391 - (49%)
• Similarity: 246/391 - (62%)
• Gaps: 46/391 - (11%)

Human     5 ESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVD 69
            |...|||||||||||||.:.|||:.|::|||:||.:.|.|||:||.|||||||||:||:....:|
  Fly    15 EEITEPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMID 79

Human    70 AAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVI 134
            .|.||||||:|||.|||||||.|::...|.|..||||:||||:::|.:|..||:||:.:|:|..:
  Fly    80 NAQNARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSV 144

Human   135 EIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGS 199
            .|::|:.:||||||||:.|||:|.||||::||.|::.....:|:||::||:|     .::|  |.
  Fly   145 NIVSDKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDM-----DRQG--GG 202

Human   200 GNFGGGRGGGFGGNDNFGRGGNFSGRGGFGG---SRGGGGYGGSGDGYNGFGNDGGYGGGGPGYS 261
            |..||.|.||.||..:.|:||     ||:||   ..|||.:||:|.| .||||.||..|||.|
  Fly   203 GGRGGPRAGGRGGQGDRGQGG-----GGWGGQNRQNGGGNWGGAGGG-GGFGNSGGNFGGGQG-- 259

Human   262 GGSRGY----GSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGS-----GSNFGGGGSYNDFGN 317
            |||.|:    ||||..:.|||.|.||      :|.|||||:|||:     |.|.||||....|||
  Fly   260 GGSGGWNQQGGSGGGPWNNQGGGNGG------WNGGGGGGYGGGNSNGSWGGNGGGGGGGGGFGN 318

Human   318 YNNQSSNFGPMKGGNFGGRSSGPY--GGGGQYFAKPRNQGG----------YGGSSSSSSYGSGR 370
            ...||...||.:..|||.....||  ||||..|.| .||||          .||.....:.|.|.
  Fly   319 EYQQSYGGGPQRNSNFGNNRPAPYSQGGGGGGFNK-GNQGGGQGFAGNNYNTGGGGQGGNMGGGN 382

Human   371 R 371
            |
  Fly   383 R 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1	NP_112420.1	Globular A domain	4..94		59/88 (67%)
		RRM1_hnRNPA1	12..92	CDD:410154	54/79 (68%)
		Globular B domain	95..185		43/89 (48%)
		RRM2_hnRNPA3	105..184	CDD:409996	38/78 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		13/33 (39%)
		RNA-binding RGG-box	218..240		10/24 (42%)
		HnRNPA1	312..344	CDD:463312	13/33 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372		25/67 (37%)
		Nuclear targeting sequence (M9)	320..357		19/48 (40%)
Hrb87F	NP_476806.2	RRM1_hnRNPA_like	25..102	CDD:409992	51/76 (67%)
		RRM_SF	116..188	CDD:473069	34/71 (48%)