Protein Alignment HNRNPA1 and Hrb98DE

DIOPT Version :10

• Sequence 1: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_524543.1
• Gene: Hrb98DE / 43385
• FlyBaseID: FBgn0001215
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 370
• Identity: 178/370 - (48%)
• Similarity: 235/370 - (63%)
• Gaps: 28/370 - (7%)

Human     5 ESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVD 69
            :|..|||.:||||||||.:.||||:|::|||:||.:.|.|||:||.|||||||||:||:....:|
  Fly    22 DSITEPEHMRKLFIGGLDYRTTDENLKAHFEKWGNIVDVVVMKDPRTKRSRGFGFITYSHSSMID 86

Human    70 AAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVI 134
            .|..:||||:|||||||||||.|:|...|.|..||||:|||.:|:|.:|..:||||:.:|.|..|
  Fly    87 EAQKSRPHKIDGRVVEPKRAVPRQDIDSPNAGATVKKLFVGALKDDHDEQSIRDYFQHFGNIVDI 151

Human   135 EIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGS 199
            .|:.|:.:|||||||||.|||:|.|||:|:||.|.:||...:|:|||.||      :.|:|..|.
  Fly   152 NIVIDKETGKKRGFAFVEFDDYDPVDKVVLQKQHQLNGKMVDVKKALPKQ------NDQQGGGGG 210

Human   200 GNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGS 264
            ....|||.||..||...|..||.:|.|.:  :.||..:|.:..|.:.:||: .:||||    ||.
  Fly   211 RGGPGGRAGGNRGNMGGGNYGNQNGGGNW--NNGGNNWGNNRGGNDNWGNN-SFGGGG----GGG 268

Human   265 RGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMK 329
            .|||.|...:||.          :.::||.|||..||.|:|:..||  ||||.| .|:...||.:
  Fly   269 GGYGGGNNSWGNN----------NPWDNGNGGGNFGGGGNNWNNGG--NDFGGY-QQNYGGGPQR 320

Human   330 -GGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSS-SSYGSGRRF 372
             ||||......||.|||.:.|...|||.|||::.. ::.|:.||:
  Fly   321 GGGNFNNNRMQPYQGGGGFKAGGGNQGNYGGNNQGFNNGGNNRRY 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1	NP_112420.1	Globular A domain	4..94		57/88 (65%)
		RRM1_hnRNPA1	12..92	CDD:410154	52/79 (66%)
		Globular B domain	95..185		48/89 (54%)
		RRM2_hnRNPA3	105..184	CDD:409996	43/78 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		12/33 (36%)
		RNA-binding RGG-box	218..240		7/21 (33%)
		HnRNPA1	312..344	CDD:463312	14/32 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372		22/56 (39%)
		Nuclear targeting sequence (M9)	320..357		16/37 (43%)
Hrb98DE	NP_524543.1	RRM1_hnRNPA_like	32..109	CDD:409992	51/76 (67%)
		RRM_SF	123..195	CDD:473069	38/71 (54%)